Newest studies

Relationship Between Dementia and Systemic Metabolic Disorders

43/100 ✓ Peer-reviewed Biomarkers Advances in experimental medicine and biology

Key finding: These findings highlight the relationship of dementia with systemic metabolic disorders and suggest the potential of using routine blood tests for dementia risk assessment.

• Lifestyle

Full summary, score breakdown and related studies → Original source

[Use of modern classification systems for complex diagnostics of Alzheimer's disease]

50/100 ✓ Peer-reviewed Biomarkers Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

Key finding: The preliminary diagnosis of AD was made in 3 patients (5%). +4 more findings

Full summary, score breakdown and related studies → Original source

The Association Between Plasma Amyloid-β 42/40 and Percentage of Semantic Intrusion Errors in Mild Cognitive Impairment

55/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD

Key finding: The aMCI plasma Aβ+ group evidenced the greatest percentage of SIEs, followed by the aMCI Aβ-. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Interaction Between Arteriosclerosis and Amyloid-β on Cognitive Function

43/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD

Key finding: Amyloid-β (Aβ)42 and arterial calcification were associated with cognitive performance. +4 more findings

Full summary, score breakdown and related studies → Original source

Anti-CMV IgG Seropositivity is Associated with Plasma Biomarker Evidence of Amyloid-β Accumulation

59/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD

Key finding: 53% of participants were CMV seropositive. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Plasma Phosphorylated Tau 231 Increases at One-Year Intervals in Cognitively Unimpaired Subjects

43/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD

Key finding: Plasma p-tau231 showed a significant rate of change over time. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Long-Term Safety of Gantenerumab in Participants with Alzheimer's Disease: A Phase III, Double-Blind, and Open-Label Extension Study (Marguerite RoAD)

77/100 ✓ Peer-reviewed Treatments Journal of Alzheimer's disease : JAD

Key finding: SC gantenerumab at doses of up to 1,200 mg Q4W were well tolerated in participants with mild AD dementia. +1 more finding

• Clinical Trials
• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

Recalibrating the Risk-Benefit Profiles of Lecanemab and Donanemab: Scales, Immunoreactivity, and Changes in Amyloid-β42

41/100 ✓ Peer-reviewed Treatments Journal of Alzheimer's disease : JAD

Key finding: Three recent anti-amyloid-β antibody trials for Alzheimer's disease reported similar effect sizes, used non-reactive saline as placebo, and showed large numbers of adverse events including imaging anomalies (ARIA) that correlate with cognitive changes. +4 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

PET/CT/MRI in Clinical Trials of Alzheimer's Disease

41/100 ✓ Peer-reviewed Treatments Journal of Alzheimer's disease : JAD

Key finding: While early immunotherapy trials of Alzheimer's disease showed no clinical effects, newer monoclonal antibody trials reported decreases of 27% to 85% in the cerebral amyloid-PET signal, interpreted by the Food and Drug Administration as amyloid removal expected to result in a reduction in clinical decline.

• Brain Scans
• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Japanese Subgroup Analyses from EMERGE and ENGAGE, Phase 3 Clinical Trials of Aducanumab in Patients with Early Alzheimer's Disease

84/100 ✓ Peer-reviewed Treatments The journal of prevention of Alzheimer's disease

Key finding: Efficacy, safety, biomarker, and PK profiles of aducanumab were consistent between the Japanese subgroup and the overall population. +4 more findings

• Clinical Trials
• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

Greater White Matter Hyperintensity Volume Is Associated with the Number of Microhemorrhages in Preclinical Alzheimer's Disease

79/100 ✓ Peer-reviewed Treatments The journal of prevention of Alzheimer's disease

Key finding: These results indicate a strong association between WMH and MCH, a common manifestation of cerebral amyloid angiopathy and ARIA-H. These results suggest that increased WMH volume may represent an early sign of vessel amyloidosis, likely prior to the emergence of MCH. +3 more findings

• Brain Scans
• Treatments
• Early Stage

Full summary, score breakdown and related studies → Original source

Initial Experience with Lecanemab and Lessons Learned in 71 Patients in a Regional Medical Center

52/100 ✓ Peer-reviewed Treatments The journal of prevention of Alzheimer's disease

Key finding: The mean age was 72 years (49-90 years), and 44 (62%) patients were female.

• Treatments

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Ultrasound Blood-Brain Barrier Opening and Aducanumab in Alzheimer's Disease

47/100 ✓ Peer-reviewed Brain scans and imaging The New England journal of medicine

Key finding: Antiamyloid antibodies have been used to reduce cerebral amyloid-beta (Aβ) load in patients with Alzheimer's disease. +4 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Validation, Deployment, and Real-World Implementation of a Modular Toolbox for Alzheimer's Disease Detection and Dementia Risk Reduction: The AD-RIDDLE Project

41/100 ✓ Peer-reviewed Cognitive tests and assessment The journal of prevention of Alzheimer's disease

Key finding: Expected results from this cross-sectoral research collaboration include tools for earlier detection and accurate diagnosis; validated, novel digital cognitive and blood-based biomarkers; and improved access to individualized preventative interventions (including multimodal interventions and symptomatic/disease-modifying therapies) across diverse populations, within the framework of precision medicine. +1 more finding

• Diagnosis
• Prevention

Full summary, score breakdown and related studies → Original source

The potential of blood neurofilament light as a marker of neurodegeneration for Alzheimer's disease

55/100 ✓ Peer-reviewed Biomarkers Brain : a journal of neurology

Key finding: The current findings suggest that blood NfL exhibits great promise as a monitoring biomarker because an increased NfL level in plasma or serum appears to reflect the current severity of atrophy, hypometabolism and the decline of white matter integrity, particularly in the brain regions typically affected by Alzheimer's disease. +2 more findings

• Biomarkers

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Neuronally Derived Extracellular Vesicle α-Synuclein as a Serum Biomarker for Individuals at Risk of Developing Parkinson Disease

69/100 ✓ Peer-reviewed Biomarkers JAMA neurology

Key finding: Overall the study included 199 participants with iRBD, 20 hyposmic participants with available dopamine transporter single-photon emission computed tomography, 146 nonmanifest GBA1N409S gene carriers, 21 GBA1N409S gene carrier patients with PD, 50 patients with sporadic PD, and 140 healthy controls. +2 more findings

• Biomarkers

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Addressing healthy aging in China: Practices and prospects

45/100 ✓ Peer-reviewed End-of-life care Bioscience trends

Key finding: China's health security, elderly care, and healthcare services are facing serious challenges as a result of this aging trend.

• Policy

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Default Palliative Care Consultation for Seriously Ill Hospitalized Patients: A Pragmatic Cluster Randomized Trial

85/100 ✓ Peer-reviewed End-of-life care JAMA

Key finding: Of 34 239 patients enrolled, 24 065 had lengths of stay of at least 72 hours and were included in the primary analytic sample (10 313 in the default order group and 13 752 in the usual care group; 13 338 [55.4%] women; mean age, 77.9 years). +1 more finding

• Clinical Trials
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Oral Health as a Risk Factor for Alzheimer Disease

65/100 ✓ Peer-reviewed Inflammation and the immune system The journal of prevention of Alzheimer's disease

Key finding: A total of 1962 studies were assessed, of which 17 studies demonstrated possible associations between oral health diseases and Alzheimer's disease. 4 theories could be distinguished that describe the possible links between oral health and the development or onset of Alzheimer's disease; 1) role of pathogens, 2) role of inflammatory mediators, 3) role of APOE alleles and 4) role of Aβ peptide.

• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

HOME HEALTH USE BY OLDER ADULTS WITH DEMENTIA: COMPARING MEDICARE ADVANTAGE AND TRADITIONAL MEDICARE

39/100 ✓ Peer-reviewed Health systems and care delivery Innovation in Aging

Key finding: Skilled home health care (HHC) is a critical service for community-dwelling older adults with dementia, but the majority of evidence about its use and quality is based on Traditional Medicare (TM) beneficiaries.

• Care Services
• Policy

Full summary, score breakdown and related studies → Original source

FUNCTIONAL OUTCOME IN HOME HEALTH AMONG TRADITIONAL MEDICARE AND MEDICARE ADVANTAGE BENEFICIARIES WITH DEMENTIA

45/100 ✓ Peer-reviewed Health systems and care delivery Innovation in Aging

Key finding: This study examines the difference in functional outcomes among Traditional Medicare (TM) and Medicare Advantage (MA) beneficiaries with Alzheimer’s disease and related dementias (ADRD) during a home health admission, which is unknown. +4 more findings

• Care Services
• Policy

Full summary, score breakdown and related studies → Original source

The Design of Insurance Contracts for Home Versus Nursing Home Long-Term Care

16/100 ⚠ Preprint — not yet peer-reviewed Health systems and care delivery Not indexed

Key finding: Individuals may be alive until the end of period 2 or die at the beginning of periods 1 or 2 with a certain probability which may depend on their state of health. +4 more findings

• Care Services
• Policy

Scored 17 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Final Project Report on Grocery Store Management System

15/100 ⚠ Preprint — not yet peer-reviewed Risk factors Not indexed

Key finding: This project provides an easy access to Administrators and Managers to view orders placed using Pay Later and Instant Pay options. +4 more findings

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The Association of Neighborhood Socioeconomic Status with Executive Function and Processing Speed in Cognitively Normal Mexican American Elders from the Health and Aging Brains Study: Health Disparities Cohort

47/100 ✓ Peer-reviewed Risk factors Dementia and Geriatric Cognitive Disorders

Key finding: MAs were younger, more likely to be female, less educated, had higher ADI scores, performed worse on trails B (all p < 0.05), and had lower prevalence of APOE4 + when compared to NHWs (p < 0.0001). +4 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source

Can integration of Alzheimer’s plasma biomarkers with MRI, cardiovascular, genetics, and lifestyle measures improve cognition prediction?

53/100 ✓ Peer-reviewed Risk factors Brain Communications

Key finding: For amyloid positive individuals Aβ42/Aβ40, glial fibrillary acidic protein and p-tau181 were the top predictors of cognitive decline while Aβ42/Aβ40 was prominent for amyloid negative participants across all age groups. +4 more findings

• Biomarkers
• Risk Factors
• Brain Scans

Full summary, score breakdown and related studies → Original source