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Diagnostic Concordance Between Plasma p-Tau217 and Amyloid-β Biomarkers in Symptomatic Alzheimer's Disease: Evidence From a Chinese Cohort
Yan J, Wang Y, Han H, Zhao T, Liu D, Chai T, Zhou Y, Yan K et al.. Research Square, 2026-08-11
Topic: Plasma and spinal-fluid biomarkers
Results Concordance between p-tau217 and Aβ was high in the AD and MCI groups (observed agreement 90.0% in each), but overall agreement across Cohort II was modest (166/351, 47.3%; Cohen's κ = 0.117, 95% CI 0.029–0.204). Among SIVD participants, concordant cases were significantly older than discordant cases (P < 0.05); no significant age or sex differences were found in the other groups. These findings support combined biomarker interpretation for AD screening and for the interpretation of discordant cases, but the absence of an independent amyloid reference standard, cognitive outcome measures, and longitudinal follow-up means the diagnostic accuracy and clinical utility of this approach require confirmation in prospective, reference-standard-anchored studies.
Key findings
- Results Concordance between p-tau217 and Aβ was high in the AD and MCI groups (observed agreement 90.0% in each), but overall agreement across Cohort II was modest (166/351, 47.3%; Cohen's κ = 0.117, 95% CI 0.029–0.204).
- Among SIVD participants, concordant cases were significantly older than discordant cases (P < 0.05); no significant age or sex differences were found in the other groups.
- These findings support combined biomarker interpretation for AD screening and for the interpretation of discordant cases, but the absence of an independent amyloid reference standard, cognitive outcome measures, and longitudinal follow-up means the diagnostic accuracy and clinical utility of this approach require confirmation in prospective, reference-standard-anchored studies.
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Study details
- Study designlongitudinal study
- Participants918
- Effect size90.0%; 47.3%; 95.7%
- Evidence strengthModerate
How this study scored 16/100
Preprint — not yet peer-reviewed. It scored 47 on the same rubric, but non-peer-reviewed sources are capped at 16, so it shows as 16. Scored zero for randomised / blinded because the record does not state it. We have no data on times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 29 of the 62 points we could judge it on, which is 47 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 2 / 10 | Tier 4 — not a peer-reviewed journal (Research Square) |
| Journal's citation record | 0 / 4 | Not a journal article, so the journal's record does not count |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 4 / 10 | Preprint — not yet peer-reviewed. Hosted on a preprint server. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 2 / 4 | 918 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 29 / 62 | Scored on 12 of 20 parts. We have no data for the rest, so they are left out: 29 of the 62 points we could judge it on is 47 out of 100. |
| Total | 47 / 100 | Capped to 16 because this is not a peer-reviewed article. |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Yan, J., Wang, Y., Han, H., Zhao, T., Liu, D., Chai, T., et al. (2026). Diagnostic Concordance Between Plasma p-Tau217 and Amyloid-β Biomarkers in Symptomatic Alzheimer's Disease: Evidence From a Chinese Cohort. Research Square. https://doi.org/10.21203/rs.3.rs-10410778/v1
Vancouver
Yan J, Wang Y, Han H, Zhao T, Liu D, Chai T, et al. Diagnostic Concordance Between Plasma p-Tau217 and Amyloid-β Biomarkers in Symptomatic Alzheimer's Disease: Evidence From a Chinese Cohort. Research Square. 2026. doi:10.21203/rs.3.rs-10410778/v1.
BibTeX
@article{yan2026-d8ff574a,
author = {Yan, J. and Wang, Y. and Han, H. and Zhao, T. and Liu, D. and Chai, T. and Zhou, Y. and Yan, K. and others},
title = {{Diagnostic Concordance Between Plasma p-Tau217 and Amyloid-β Biomarkers in Symptomatic Alzheimer's Disease: Evidence From a Chinese Cohort}},
journal = {Research Square},
year = {2026},
doi = {10.21203/rs.3.rs-10410778/v1},
url = {https://doi.org/10.21203/rs.3.rs-10410778/v1}
}
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