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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 126–150 of 27,380 studies, newest first · page 6 of 1096.

October 2026 25

  1. 2026-10-20

    Plasma Neurofilament Light Chain is Markedly Elevated in General Hospital Inpatients with Delirium

    ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv

    Key finding: In Phase 1 (n =176), inpatients with delirium showed higher concentrations of both NfL and GFAP than patients with dementia (β = 0.78; 95% CI [0.37, 1.20] and β = 0.39 [0.07, 0.73] respectively) or PPD groups (β = 1.17; [0.69, 1.66] and β = 0.83 [0.51, 1.24] respectively). +4 more findings

    Scored 44 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  2. 2026-10-19

    Memory Intraindividual Variability and its Association with Hippocampal Integrity in Older Latino Adults Without Dementia

    ⚠ Preprint — not yet peer-reviewed Disparities medRxiv

    Key finding: Memory IIV may be more closely linked to hippocampal white matter, while mean memory performance may better reflect hippocampal volume. +2 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  3. 2026-10-19

    Patient-Reported Shared Decision-Making and Documented Advance Care Planning Among Adults With Alzheimer’s Disease and Related Dementias

    ⚠ Preprint — not yet peer-reviewed End-of-life care medRxiv

    Key finding: Among adults with ADRD, high SDM was associated with greater ACP prevalence in unadjusted analyses, although the fully adjusted association was not statistically significant. +4 more findings

    Scored 37 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  4. 2026-10-19

    Convergent Mitochondrial and Oxidative Stress Signatures in Spaceflight and Tauopathy: A Comparative Multi-Omics Reanalysis in Drosophila melanogaster

    ⚠ Preprint — not yet peer-reviewed Disease mechanisms bioRxiv

    Key finding: Mitochondrial dysfunction is a shared biological thread between terrestrial Alzheimer’s disease (AD) and in the unique stress environment of spaceflight, making mitochondrial pathophysiology a compelling target for comparative investigation. +4 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  5. 2026-10-19

    The Alzheimer’s disease risk gene ABCA7 regulates microglial lysosomal and lipid homeostasis and promotes phagocytosis to maintain neuronal health

    ⚠ Preprint — not yet peer-reviewed Disease mechanisms bioRxiv

    Key finding: ABCA7-KO iMGs were deficient for proteins involved in lysosome function, measured by down-regulated lysosomal proteomic signatures, as well as reduced DQ-BSA activity and reduced LAMP1+ area. +4 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  6. 2026-10-19

    LATS2 modulates synaptic organization and function by regulating actin dynamics

    ⚠ Preprint — not yet peer-reviewed Disease mechanisms bioRxiv

    Key finding: Previously, we demonstrated that LATS1 plays an important role in synapse development; however, the role of LATS2 remains poorly understood. +2 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  7. 2026-10-19

    Change in gut microbiome precedes symptomatic Alzheimer’s disease and is correlated with amyloid-beta accumulation in the brain

    ⚠ Preprint — not yet peer-reviewed Disease mechanisms medRxiv

    Key finding: Early Ap accumulation is associated with distinct gut microbial signatures and reduced neuroactive metabolic potential, identifying targets for potential preclinical AD intervention. +2 more findings

    Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  8. 2026-10-19

    Comorbidities of dementia in electronic health records: validation of a natural language processing app and comparison with data linkage

    ⚠ Preprint — not yet peer-reviewed Risk factors medRxiv

    Key finding: MedCAT Comorbidity demonstrated predictive ability for mortality (HR 1.11 per condition), although the model fit was better using comorbidity from hospital admission data. +3 more findings

    Scored 39 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  9. 2026-10-19

    Sequence-based variant-effect predictions reveal trait-specific regulatory-layer profiles of complex-trait heritability

    ⚠ Preprint — not yet peer-reviewed Risk factors medRxiv

    Key finding: These results identify differences across traits in the heritability information captured by predicted regulatory layers and offer testable hypotheses for investigating the regulatory basis of complex traits.

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  10. 2026-10-19

    Longitudinal associations between neuropsychiatric symptoms, structural and perfusion MRI changes in older adults with Mild Cognitive Impairment

    ⚠ Preprint — not yet peer-reviewed Brain scans and imaging medRxiv

    Key finding: There were significant reductions in total grey matter and white matter volumes, together with volume loss in the bilateral hippocampus, bilateral parahippocampal gyrus and right entorhinal cortex (p FDR< 0.05) over the follow up period. +3 more findings

    Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  11. 2026-10-19

    Female microglia show heightened responses to aging and amyloid pathology in mice and humans

    ⚠ Preprint — not yet peer-reviewed Risk genes beyond APOE bioRxiv

    Key finding: These findings identify conserved regulatory networks that may contribute to female-biased microglial responses to AD pathology across mice and humans. +4 more findings

    Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  12. 2026-10-19

    NADPH attenuates tau pathology and disease-associated microglial phenotype in a truncated tau- induced mouse model

    ⚠ Preprint — not yet peer-reviewed TREM2 and immune genetics Research Square

    Key finding: Transcriptomic profiling further revealed that tau Tr elicits a ROS-associated and pro-inflammatory program, characterized by activation of NF-κB signaling and closely resembling transcriptional signatures observed in tau transgenic models. +3 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  13. 2026-10-19

    Structured Metabolic Genetic Axes Reveal Distinct Lipid and Ketone-Body Programs in Alzheimer’s and Parkinson’s Disease

    ⚠ Preprint — not yet peer-reviewed Genetics Research Square

    Key finding: Structured metabolic genetic axes reveal selective and biologically distinct links between circulating metabolism and neurodegenerative disease, providing a framework for mechanism-focused follow-up beyond single-metabolite association.

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  14. 2026-10-19

    Reproductive Aging, FSH, and Apolipoprotein Biology in Alzheimer’s Disease

    ⚠ Preprint — not yet peer-reviewed Genetics Preprints.org

    Key finding: Estrogen deficiency has long been a leading explanation for this sex difference, but emerging evidence suggests that follicle-stimulating hormone (FSH) may represent an additional, contributory endocrine factor. +4 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  15. 2026-10-19

    Plasma neurofilament light links mortality to neuroaxonal injury beyond clinical decline and Alzheimer disease plasma biomarkers: a multi-cohort study of oldest old individuals

    ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv

    Key finding: Blood-based neurofilament light (NfL) is associated with all-cause mortality, but whether this reflects neuroaxonal injury or overlaps with cognitive and functional decline remains unclear. +2 more findings

    Scored 37 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  16. 2026-10-19

    Basal Ganglia Iron Accumulation Mediates Stage-Dependent Associations Between Plasma pTau217 and Hippocampal Atrophy in Alzheimer’s Disease

    ⚠ Preprint — not yet peer-reviewed Biomarkers Research Square

    Key finding: Basal ganglia iron serves as a stage-dependent mediator linking pTau217 to hippocampal neurodegeneration, with prodromal AD potentially indicating a particularly vulnerable stage for iron-targeted interventions and iron profiling for patient stratification.

    Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  17. 2026-10-19

    Performance boundaries of plasma-centred prediction across PET- and MRI-defined AT(N): QC-first internal validation in ADNI with separate axis-specific assessments

    ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv

    Key finding: ADNI identified task-dependent performance boundaries, particularly attenuated conditional T discrimination within A+. +1 more finding

    Scored 37 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  18. 2026-10-19

    Genetic Architecture of Plasma Amyloid and Tau Biomarkers in the Amish

    ⚠ Preprint — not yet peer-reviewed Tau biomarkers medRxiv

    Key finding: GWAS found associations between plasma biomarkers and the APOE gene. +4 more findings

    Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  19. 2026-10-18

    Cognitive Impairment during Migraine Attacks: An Analysis from the American Registry for Migraine Research (ARMR)

    ⚠ Preprint — not yet peer-reviewed Mild cognitive impairment Research Square

    Key finding: Among 1,231 patients (87.2% women; mean age 46.0 ± 13.7 years; 71.5% chronic migraine), 1,175/1,231 (95.5%) endorsed cognitive symptoms, with a mean Mig-SCog total score of 8.2 ± 4.8. +4 more findings

    Scored 42 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  20. 2026-10-18

    Spatiotemporal transcriptomic dynamic across the auditory pathway from young to old age in 5xFAD Alzheimer disease mice

    ⚠ Preprint — not yet peer-reviewed Disease mechanisms bioRxiv

    Key finding: These findings define a distributed, asynchronous response rather than a monotonic bottom-up or top-down progression.

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  21. 2026-10-18

    Mapping post-translational modifications across amyloid-β deposits in Alzheimer’s disease: A neuropathologic survey with in vitro functional analysis of nitration

    ⚠ Preprint — not yet peer-reviewed Treatments Research Square

    Key finding: Distinct PTMs delineate the compartment-specific architectural signatures of Aβ deposits. +1 more finding

    Scored 23 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  22. 2026-10-18

    DNA-Encoded Library-Guided Discovery of a First-in-Class Molecular Glue of the NOS1AP-SCRIB Complex in Alzheimer’s Disease Patient-Derived Neurons

    ⚠ Preprint — not yet peer-reviewed Biomarkers bioRxiv

    Key finding: Efforts to drug NOS1AP have sought to disrupt these; we instead report pharmacological stabilization of one interaction. +4 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  23. 2026-10-18

    Evidence for Reduced Somatic T-Cell Receptor Sequence Diversity Profiles Among Midwestern Amish in an Aging Cohort Study

    ✓ Peer-reviewed Tau biomarkers Annals of human genetics

    Key finding: TCR sequence diversity measured as Simpson's clonality was lower among LOAD+MCI compared with non-LOAD, but these differences were not independent of age. +2 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2026-10-17

    NeuroMark dFNC: Transferable Dynamic-State Templates for Subject-Specific and Frequency-Resolved Chronnectomics

    ⚠ Preprint — not yet peer-reviewed Brain scans and imaging bioRxiv

    Key finding: Fractional occupancy and conditional mean dwell time were calculated from the state with the largest absolute calibrated loading at each observation. +4 more findings

    Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  25. 2026-10-16

    Understanding Performance Plateaus and Representation Collapse in 3D MRI Transformers Trained to Classify Brain Disease

    ⚠ Preprint — not yet peer-reviewed Digital health tools bioRxiv

    Key finding: To distinguish these cases, we trained three types of supervised 3D transformers (ViT3D, MINiT, NIT) and, as a non-collapsing alternative, a frozen self-supervised encoder (DINO), to classify people with dementia or mild cognitive impairment (MCI) versus cognitively normal (CN) individuals from 3D brain MRI, using data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). +1 more finding

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →