Newest studies

Patient-Driven Grouping Model and Home Health Use Among Traditional Medicare Beneficiaries

42/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Medical Directors Association

Key finding: Beneficiaries with ADRD experienced a steeper decline in total visits (from 22.4 to 17.9) compared with those without ADRD (from 18.2 to 15.4), driven by reductions in therapy visits, which fell from 12.9 to 9.9 among beneficiaries with ADRD and from 9.8 to 8.3 among those without ADRD.

• Care Services
• Policy

Full summary, score breakdown and related studies → Original source

Dementia Knowledge and Perceived Competence in Dementia Care among Healthcare Workers in South Africa

45/100 ✓ Peer-reviewed Disparities F1000Res

Key finding: This study reveals a critical disconnect between moderate dementia knowledge and the application of this knowledge into perceived clinical competence. +3 more findings

Full summary, score breakdown and related studies → Original source

HnRNPAB -targeted antisense oligonucleotides ameliorate tau pathology and cognitive deficits by modulating Alzheimer’s disease-associated alternative splicing

16/100 ⚠ Preprint — not yet peer-reviewed Drug development bioRxiv

Key finding: Transcriptomic analysis of post-mortem brain tissues from AD patients revealed reduced expression of hnRNPAB , while selective downregulation of AB332 was confirmed in the hippocampus of 3xTg AD mice. +1 more finding

• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Loss of the lncRNA SOX1-OT promotes p53-dependent cell-cycle arrest in astrocytes

16/100 ⚠ Preprint — not yet peer-reviewed Drug development bioRxiv

Key finding: Antisense oligonucleotide-mediated depletion of Sox1ot in astrocytes revealed a transcriptional program marked by activation of p53 target genes selectively associated with cell-cycle inhibitory pathways. +2 more findings

• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Dissociable structural and molecular pathways of age-related variability in sustained attention

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers bioRxiv

Key finding: Older age was associated with lower Att-Z (β = −0.315, p < 0.001). +4 more findings

• Biomarkers

Scored 44 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Mapping Digital and Assistive Technologies for Dementia and Related Neurodegenerative Conditions: A Scoping Review

16/100 ⚠ Preprint — not yet peer-reviewed Disparities medRxiv

Key finding: We identified 23,453 records published between 2001 and 2025, of which 325 studies met the inclusion criteria. +4 more findings

• Digital Tools

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Person-Centredness in Dementia Diagnosis & Detection: A Scoping Review

16/100 ⚠ Preprint — not yet peer-reviewed End-of-life care Research Square

Key finding: We included 23 studies with qualitative (73.9%) or quantitative/mixed-methods (26.1%) designs. +4 more findings

• Diagnosis

Scored 45 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Protocol for the 2026 Nationwide Survey of Dementia Specialists on the Real-World Implementation of Anti-Amyloid Antibody Therapies in Japan: Clinical Practice, Blood Biomarkers, and Preference Experiments

16/100 ⚠ Preprint — not yet peer-reviewed End-of-life care medRxiv

Key finding: Data collection started on June 3, 2026, and is planned to close on June 30, 2026. +1 more finding

• Treatments

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Can modifiable dementia risk factors help account for the predictive link between personality and midlife cognitive health? Evidence from a 17-year longitudinal study of Mexican-origin adults

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors PsyArXiv

Key finding: All Big Five domains had prospective associations with multiple dementia risk factors and with cognitive impairment, cognitive function, and self-reported memory. +4 more findings

• Risk Factors
• Prevention

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Association of sleep duration with Alzheimer's disease and cognition

61/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Sleep duration exhibited a U-shaped association with SPARE-AD (p = 0.001), Trail Making Tests A and B, and the Digit Symbol Substitution Test (all p < 0.001). +4 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

A phase-II randomized controlled pilot study of nicotinamide riboside supplementation in older adults with amnestic mild cognitive impairment

84/100 ✓ Peer-reviewed Clinical trials Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: 42 participants completed the study (NR = 22, placebo = 20). +4 more findings

• Clinical Trials
• Early Stage

Full summary, score breakdown and related studies → Original source

Relationships of CSF biomarkers to cortical atrophy in early-onset Alzheimer's disease

48/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: The levels of four CSF biomarkers correlated to EOAD signature atrophy. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration

53/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Proinflammatory Component 2 was elevated in AD/MCI and in Black/African American participants, and strongly associated with poorer cognition (independently of neurofilament light [NfL], phosphorylated tau 217 [p-tau217], and glial fibrillary acidic protein [GFAP]). +2 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Alzheimer's blood-based biomarkers, incident dementia, and interactions with age, APOE status, and hormone therapy

88/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Lower baseline amyloid beta (Aβ)42/40 ratio and higher phosphorylated tau 181 (p-tau181), glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) were associated with an increased risk of MCI and dementia; GFAP was most strongly associated. +4 more findings

• Biomarkers
• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Multicenter validation of plasma p-tau217/ amyloid beta 1-42 ratio in symptomatic Alzheimer's disease

61/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Amyloid status was determined by CSF in 347 patients (189 positive [54.5%]) and by PET imaging in 152 patients (66 positive [43.4%]). +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Plasma Amyloid-β 1-40 and Postoperative Delirium After Cardiac Surgery

73/100 ✓ Peer-reviewed Biomarkers JAMA network open

Key finding: Of 504 enrolled patients, 491 completed POD assessment (mean [SD] age, 68.4 [8.3] years; 385 [78.4%] male), of whom 106 (21.6%) developed POD. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Prognostic value of plasma %p-tau217 in cognitively unimpaired older adults

79/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Participants with Elevated/High %p-tau217 exhibited accelerated cognitive decline, hippocampal atrophy, and significantly higher risks of progression to MCI (hazard ratio [HR] > 6.0) and dementia (HR > 9.9). +3 more findings

• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Blood-based circular RNAs for early diagnosis of Alzheimer's disease

68/100 ✓ Peer-reviewed Biomarkers Nature medicine

Key finding: Here, analyzing blood data from 1,221 individuals with AD and healthy individuals, we identified 34 circRNAs associated with AD status. +1 more finding

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Patient‐derived forebrain cortical organoids reveal biphasic tau–MAP6–microtubule axis dysfunction in tauopathy

34/100 ✓ Peer-reviewed Disease mechanisms Alzheimer s & Dementia

Key finding: Early-phase tau mutant organoids showed elevated tau, hyperdynamic microtubules, and neuronal hyperexcitability, partially reversible by tau reduction. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

PDE4A knockdown rescues alcohol-induced cognitive impairment and synaptic dysfunction via the cAMP/PKA/CREB pathway

33/100 ✓ Peer-reviewed Disease mechanisms The International Journal of Neuropsychopharmacology

Key finding: This study demonstrated that selectively targeting PDE4A rescued cognitive and neuropathological deficits in a validated mouse model of AlD. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Neuropathologic Correlates of Seizures in Patients With Alzheimer Disease and Dementia With Lewy Bodies

49/100 ✓ Peer-reviewed Brain tissue and pathology Neurology

Key finding: In this autopsy-confirmed cohort, seizure susceptibility was associated with advanced tau pathology and CAA in AD. +3 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Development and characterization of a novel TDP‐43 positron emission tomography tracer: [ 18 F]JNJ‐TDP43‐1

36/100 ✓ Peer-reviewed Brain tissue and pathology Alzheimer s & Dementia

Key finding: = 7.1 nM) and remarkable selectivity over other proteinopathies. +3 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

MMSE–CDR‐SB residual as an exploratory indicator of deviation from an Alzheimer's disease–typical cognitive–functional pattern

43/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring

Key finding: The MMSE–CDR‐SB residual may help flag less AD‐typical presentations for further etiologic evaluation, but cannot be interpreted as a pathology‐specific marker due to substantial overlap across diagnostic groups. +1 more finding

• Diagnosis

Full summary, score breakdown and related studies → Original source

Triazole Hybrids for Alzheimer's Disease: Multitarget Potential and SAR Insights

27/100 ✓ Peer-reviewed Risk genes beyond APOE ChemistrySelect

Key finding: These findings support the use of triazole scaffolds as a unique and versatile framework for developing multifunctional anti‐Alzheimer agents with perceived disease‐modifying activity. +1 more finding

Full summary, score breakdown and related studies → Original source

Early behavioural and adaptive markers of dementia in adults with Down syndrome

32/100 ✓ Peer-reviewed Down syndrome and Alzheimer's International Journal of Intellectual Disability

Key finding: How do clinicians distinguish early-stage dementia from the expected cognitive variability seen in ageing adults with Down syndrome? +1 more finding

• Down Syndrome

Full summary, score breakdown and related studies → Original source