Newest studies

The role of brain MR and FDG-PET in the diagnosis of neurodegenerative disease

35/100 ✓ Peer-reviewed Treatments European Radiology

Key finding: This review article explores brain MRI and FDG-PET/CT imaging abnormalities in patients with major cognitive and movement disorders associated with dementia.

• Brain Scans
• Treatments
• Diagnosis

Full summary, score breakdown and related studies → Original source

Progressive Supranuclear Palsy—A Global Review

42/100 ✓ Peer-reviewed Risk factors Movement Disorders Clinical Practice

Key finding: Global PSP prevalence ranges between 5-6.4 per 100,000, influenced by diagnostic criteria and healthcare infrastructure. +4 more findings

Full summary, score breakdown and related studies → Original source

The Occurrence of Obstructive Sleep Apnea and Its Association With Alzheimer Dementia in Medicaid-Enrolled Adults With Down Syndrome, 2011-2019

44/100 ✓ Peer-reviewed Down syndrome and Alzheimer's American journal of medical genetics. Part A

Key finding: Due to distinct body and facial morphology, people with Down syndrome appear to be at increased risk for obstructive sleep apnea (OSA). +3 more findings

• Down Syndrome
• Policy

Full summary, score breakdown and related studies → Original source

Pulse pressure as a predictor of Alzheimer's disease biomarkers and cognitive decline: The moderating role of APOE ε4

62/100 ✓ Peer-reviewed Treatments The journal of prevention of Alzheimer's disease

Key finding: Higher baseline PP was significantly associated with increased Aβ (β = 0.078; p = 0.001), inferior temporal tau (β = 0.110; p = 0.032), and meta-temporal tau deposition (β = 0.116; p = 0.022). +3 more findings

• Treatments
• Genetics
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Optineurin deficiency disrupts phosphorylated tau proteostasis and clusterin expression in human neurons

43/100 ✓ Peer-reviewed Disease mechanisms Acta neuropathologica communications

Key finding: Analyses revealed a significant negative correlation between OPTN and specific pTau epitopes in neurons, as well as a decrease in OPTN protein abundance in brain tissues of individuals with AD. +3 more findings

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Biomarker-related phospho-tau217 appears in synapses around Aβ plaques prior to tau tangle in cerebral cortex of preclinical Alzheimer's disease

43/100 ✓ Peer-reviewed Biomarkers Cell reports

Key finding: Phospho-tau protein p-tau181 is a cerebrospinal fluid biomarker for Alzheimer's disease (AD), while p-tau217 is the most sensitive plasma biomarker for cerebral amyloid β (Aβ) load prior to tau pathology in preclinical AD. +4 more findings

• Biomarkers
• Brain Biology
• Early Stage

Full summary, score breakdown and related studies → Original source

Long-term value of lecanemab to individuals and families

41/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer's & dementia (New York, N. Y.)

Key finding: There is significant value of lecanemab for persons with mild cognitive impairment or mild dementia.

• Treatments
• Caregiving
• Policy

Full summary, score breakdown and related studies → Original source

TDP ‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models

43/100 ✓ Peer-reviewed Brain tissue and pathology FEBS Journal

Key finding: These hallmark pathological features are associated with widespread neuronal dysfunction and progressive neurodegeneration.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Effect of depression on risks of Alzheimer’s disease and vascular dementia: A real-world longitudinal study

55/100 ✓ Peer-reviewed Lewy body dementia Psychiatry Research

Key finding: During an average follow-up of 3.63 years, we observed a total of 1 493 individuals developing dementia among 4 341 depressed and 43 214 matched non-depressed individuals (62.4% female; mean [SD] age at baseline 64.4 [11.1] years). +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Patient and Caregiver Outcomes of Health System, Community-Based, and Usual Dementia Care

55/100 ✓ Peer-reviewed Caregiving JAMA Internal Medicine

Key finding: A total of 2176 person living with dementia-caregiver dyads were enrolled; 1271 persons living with dementia (58.4%) and 1650 caregivers (75.8%) were female, and their mean (SD) age were 80.6 (8.5) years and 65.2 (12.3) years, respectively. +4 more findings

• Caregiving
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Sketching a Space of Brain States

39/100 ✓ Peer-reviewed Brain scans and imaging Neuroinformatics

Key finding: They consist in changes in how brain functional networks work. +4 more findings

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A critical review and classification of dementia risk assessment tools to inform dementia risk reduction

56/100 ✓ Peer-reviewed Prevention and risk The Journal of Prevention of Alzheimer s Disease

Key finding: Dem-NCD, CogDrisk, ANU-ADRI and LIBRA risk scores incorporated most WHO-recommended risk factors and demonstrated accuracy comparable to the overall pooled C-statistic. +1 more finding

• Prevention
• Risk Factors

Full summary, score breakdown and related studies → Original source

Alzheimer Disease Biomarkers and Subjective Cognitive Decline Among Hispanic and/or Latino Adults

57/100 ✓ Peer-reviewed Tau biomarkers JAMA network open

Key finding: Subjective cognitive decline (SCD) may be an early indicator of Alzheimer disease and related dementias (ADRD), yet its association with plasma biomarkers remains unclear among middle-aged and older adults (aged 50-86 years). +3 more findings

• Biomarkers
• Health Equity
• Early Stage

Full summary, score breakdown and related studies → Original source

Concordance between Centiloid Quantification and Visual Interpretation of Amyloid PET Scans across the Alzheimer Disease Continuum

43/100 ✓ Peer-reviewed Biomarkers AJNR. American journal of neuroradiology

Key finding: Global CL quantification of Aβ PET scans is highly concordant with visual interpretation. +2 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer's disease

50/100 ✓ Peer-reviewed Laboratory science Immunity

Key finding: Here, we found that ZBP1 is amplified in AD microglia, driving innate immune responses and neuroinflammation through sensing Z-form mitochondrial DNA (mtDNA). +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Automated Plasma Phospho-tau217 Assays for the diagnosis of Down Syndrome-Related Alzheimer's Disease

16/100 ⚠ Preprint — not yet peer-reviewed Down syndrome and Alzheimer's Research Square

Key finding: These results are comparable to composite plasma measures. +1 more finding

• Down Syndrome
• Diagnosis
• Biomarkers

Scored 23 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Adiponectin Receptor Agonist Ameliorates Synaptic Dysfunction in 3xTg Alzheimer's Disease Mouse Model by Activation of AMPK

43/100 ✓ Peer-reviewed Disease mechanisms CNS neuroscience & therapeutics

Key finding: Incubation of hippocampal slices with AdipoRon ameliorated long-term potentiation (LTP) and basal synaptic transmission deficits in 3xTg-AD mice. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

PINK1 deficiency permits the development of Lewy body dementia with coexisting Aβ pathology

46/100 ✓ Peer-reviewed Brain tissue and pathology Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: DLB brains show PINK1 deficiency alongside α-syn and Aβ co-pathology. +4 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

The Microbiota-Gut-Brain Connection: A New Horizon in Neurological and Neuropsychiatric Disorders

43/100 ✓ Peer-reviewed Disease mechanisms CNS neuroscience & therapeutics

Key finding: This review explores the molecular processes underlying MGBA interactions, including vagus nerve signaling, systemic immunological responses, and metabolites produced by microorganisms. +4 more findings

• Treatments

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Pseudo-dementia caused by metformin-induced vitamin B12 deficiency

48/100 ✓ Peer-reviewed Drug development Psychiatria Danubina

Key finding: There is a significant association between long-term metformin therapy and an increased prevalence of vitamin B12 deficiency.

• Lifestyle

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Real-world observations of GLP-1 receptor agonists and SGLT-2 inhibitors as potential treatments for Alzheimer's disease

54/100 ✓ Peer-reviewed Drug development Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: We identified GLP-1 receptor agonist initiation compared to DPP-4 inhibitors initiation was associated with a reduced risk of AD (hazard ratio [HR] ≤ 0.69 and P value < 0.001) and SGLT-2 inhibitor initiation compared to DPP-4 inhibitor initiation was associated with a reduced risk of AD (HR ≤ 0.67 and P value < 0.001). +4 more findings

• Treatments
• Risk Factors

Full summary, score breakdown and related studies → Original source

[Pharmacological Interventions in Dementia]

43/100 ✓ Peer-reviewed Treatments No shinkei geka. Neurological surgery

Key finding: In 2021, the first drug targeting Aβ, aducanumab, was launched in the USA. +4 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Safety of switching from lecanemab to donanemab in 20 consecutive patients with Alzheimer's disease

43/100 ✓ Peer-reviewed Treatments Journal of Alzheimer's disease : JAD

Key finding: No new amyloid-related imaging abnormalities (ARIA) or significant adverse events were observed during the first five donanemab infusions. +1 more finding

• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

Comparison of amyloid PET acquired through standardized and unstandardized protocols

46/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Within each tracer, GMM-derived amyloid negative (A-) CL distributions were similar across cohorts. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Polygenic risk score of Alzheimer's disease is associated with cognitive trajectories and phenotypes of cerebral organoids

52/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: OptPRS predicted AD dementia and Aβ positivity, independent of apolipoprotein E (APOE). +4 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source