Newest studies

Blood-based analysis of different tau variants in patients with multiple traumatic injuries

38/100 ✓ Peer-reviewed Tau biomarkers Digitalen Hochschulbibliothek Sachsen-Anhalt (Universitäts- und Landesbibliothek Sachsen-Anhalt)

Key finding: Median serum levels of tau variants were increased in patients with multiple traumatic injuries at day 0 compared with controls (t-tau: 43 [IQR, 21-95] vs 3 [IQR, 3-5] pg/mL; BD-tau: 78 [IQR, 30-343] vs 2 [IQR, 2-3] pg/mL; p-tau231: 61 [IQR, 21-79] vs 2 [IQR, 1-3] pg/mL; all, P < .001). +1 more finding

• Biomarkers

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In silico structure-based multi-targeted molecular docking analysis of ginkgo biloba phytocompounds against Alzheimer’s disease associated proteins

27/100 ✓ Peer-reviewed Risk genes beyond APOE In Silico Research in Biomedicine

Key finding: Analysis of interaction showed that hydrogen bonding and hydrophobic contacts were found in the specified binding areas.

• Brain Biology

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IMAGING OF THE BONE ARCHITECTURE IN THE CONTEXT OF ALZHEIMER DISEASE

42/100 ✓ Peer-reviewed Risk genes beyond APOE Osteoarthritis Imaging

Key finding: Female Psen1 mutation(L166P) mice were found to have reductions in whole-body mineral density (BMD) and bone mineral content as early as one month and a sustained bone phenotype with age with loss in cortical and trabecular properties compared to age-and gendermatched wildtype control mice, whereas male mice did not (Fig.1A-C). +4 more findings

• Genetics
• Brain Scans
• Brain Biology

Full summary, score breakdown and related studies → Original source

Effect of deep brain stimulation on patients with Parkinson’s disease with mild cognitive impairment

54/100 ✓ Peer-reviewed Mild cognitive impairment BMJ Neurology Open

Key finding: Eight studies comprising 984 patients met inclusion criteria. +4 more findings

• Early Stage

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Rationale and design of a multidomain lifestyle program for mild cognitive impairment

40/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s & Dementia

Key finding: CEP comprises four cores (Therapeutic Programs, Technology, Built Environment, and Innovation Accelerator) that map to the conceptual framework. +4 more findings

• Early Stage
• Lifestyle

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Individualized prediction of transition from subjective cognitive decline to mild cognitive impairment based on multimodal MRI: a 10-year follow-up study

38/100 ✓ Peer-reviewed Mild cognitive impairment The Journal of Prevention of Alzheimer s Disease

Key finding: The model incorporating age, brain volume, functional, and radiomics features demonstrated the highest predictive performance for SCD progression in training (C-index: 0.962; 95 % CI: 0.95-0.98) and testing (C-index: 0.911; 95 % CI: 0.861-0.968) sets. +4 more findings

• Early Stage
• Brain Scans

Full summary, score breakdown and related studies → Original source

Preclinical Catecholaminergic Biomarkers of Central Lewy Body Diseases

49/100 ✓ Peer-reviewed Lewy body dementia Journal of Clinical Neurology

Key finding: In the central Lewy body diseases (LBDs) Parkinson's disease and dementia with Lewy bodies (DLB), by the time parkinsonism or cognitive dysfunction manifests, substantial central neurodegeneration has already occurred. +4 more findings

• Other Dementias
• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

EEG network reorganization across Alzheimer's disease, frontotemporal dementia, and dementia with Lewy bodies

42/100 ✓ Peer-reviewed Lewy body dementia Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring

Key finding: AD showed canonical slowing with delta/theta increases and posterior alpha loss. +3 more findings

• Other Dementias

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Vascular dementia: World Stroke Organization fact sheet 2026

51/100 ✓ Peer-reviewed Lewy body dementia International Journal of Stroke

Key finding: Despite the importance of VaD, it remains underrecognized and underresearched compared to other forms of dementia.

• Other Dementias

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Novel insights into Alzheimer's disease through the study of individuals with Down syndrome

47/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer s & Dementia

Key finding: Novel insights into Alzheimer's disease through the study of individuals with Down syndromePeople with Down syndrome (DS) represent the largest genetically defined population at risk for Alzheimer's disease (AD). 1 Virtually all adults with DS develop AD neuropathology by midlife due to triplication

• Down Syndrome
• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Midlife and late‐life population attributable fractions of risk factors for dementia in the United States: The Dementia Risk Prediction Project

73/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Midlife and late-life risk factors contributed to 22.7% and 16.5% of total dementia cases, respectively. +4 more findings

• Risk Factors

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The potential for dementia prevention in Japan: a population attributable fraction calculation for 14 modifiable risk factors and estimates of the impact of risk factor reductions

43/100 ✓ Peer-reviewed Risk factors The Lancet Regional Health - Western Pacific

Key finding: The weighted combined PAF for all 14 risk factors was 38.9%, indicating that nearly 4 in 10 dementia cases in Japan might be preventable. +4 more findings

• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Lessons learned in the recruitment and retention of Black males in informal dementia caregiving research

44/100 ✓ Peer-reviewed Disparities Alzheimer s & Dementia

Key finding: Of the n = 180 participants recruited, n = 77 participated in this study, n = 37 caregivers and n = 40 non-caregivers. +4 more findings

• Health Equity
• Caregiving

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Beyond black‐box AI: Interpretable hybrid systems for dementia care

36/100 ✓ Peer-reviewed Disparities Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring

Key finding: We propose a three-level framework for hybrid AI integration: (1) knowledge retrieval with linked citations; (2) contextualized decision support that combines predictive models with actionable plans derived from expert rules; and (3) adaptive optimization through continuous feedback. +4 more findings

• Digital Tools

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Community-engaged intervention mapping for developing the DIGNITY program: Supporting decision-making in aging and dementia for autonomy in rural nursing homes

43/100 ✓ Peer-reviewed Disparities Journal of Clinical and Translational Science

Key finding: A total of 53 stakeholders participated in focus groups and engagement sessions. +4 more findings

• Health Equity

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Anticipatory grief among caregivers of people living with dementia: A scoping review

38/100 ✓ Peer-reviewed Caregiving Palliative & Supportive Care

Key finding: Thirty articles met the inclusion criteria. +4 more findings

• Caregiving

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Alzheimer Detection And Classification Using SVM

44/100 ✓ Peer-reviewed Brain scans and imaging Zenodo (CERN European Organization for Nuclear Research)

Key finding: This leads to more precise and stable classification results, even with smaller datasets compared to existing ML models, the proposed SVM model achieves higher accuracy, sensitivity, and specificity, making it more dependable for automatic Alzheimer's detection. +1 more finding

• Brain Scans

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Alzheimer Detection And Classification Using SVM

31/100 ✓ Peer-reviewed Brain scans and imaging Zenodo (CERN European Organization for Nuclear Research)

Key finding: This leads to more precise and stable classification results, even with smaller datasets compared to existing ML models, the proposed SVM model achieves higher accuracy, sensitivity, and specificity, making it more dependable for automatic Alzheimer's detection. +1 more finding

• Brain Scans

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Longitudinal Structural MRI-Based Deep Learning And Radiomics Features For Predicting Alzheimer\\\\\\\'s Disease Progression

55/100 ✓ Peer-reviewed Brain scans and imaging Zenodo (CERN European Organization for Nuclear Research)

Key finding: This paper presents a comprehensive review of a re-cent longitudinal MRI-based study by Aghajanian et al. [1], which integrates three-dimensional (3D) convolutional neural networks (CNNs), time-aware long short-term memory (T-LSTM) networks with attention mechanisms, and radiomics features to predic +4 more findings

• Brain Scans
• Digital Tools

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Longitudinal Structural MRI-Based Deep Learning And Radiomics Features For Predicting Alzheimer\\\\\\\'s Disease Progression

39/100 ✓ Peer-reviewed Brain scans and imaging Zenodo (CERN European Organization for Nuclear Research)

Key finding: This paper presents a comprehensive review of a re-cent longitudinal MRI-based study by Aghajanian et al. [1], which integrates three-dimensional (3D) convolutional neural networks (CNNs), time-aware long short-term memory (T-LSTM) networks with attention mechanisms, and radiomics features to predict MCI-to-AD conversion using structural MRI. +4 more findings

• Brain Scans
• Digital Tools

Full summary, score breakdown and related studies → Original source

Multimodal Deep Learning for Dynamic and Static Neuroimaging: Integrating MRI and fMRI for Alzheimer Disease Analysis

32/100 ✓ Peer-reviewed Brain scans and imaging Journal of Machine Learning for Modeling and Computing

Key finding: Magnetic Resonance Imaging (MRI) provides detailed structural information, while functional MRI (fMRI) captures temporal brain activity. +1 more finding

• Brain Scans
• Digital Tools

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Structural Brain Correlates With Appetite and Eating Disturbances Across the Alzheimer Disease Spectrum

47/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer Disease & Associated Disorders

Key finding: Appetite disturbances were present in 9.4% of participants and were associated with greater neuropsychiatric burden and disease severity. +3 more findings

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The Role of Lifestyle and Diet in the Treatment of Endometriosis: A Review

42/100 ✓ Peer-reviewed Prevention and risk Nutrients

Key finding: Endometriosis is a chronic, oestrogen-dependent inflammatory condition affecting approximately 10% of women of reproductive age, frequently associated with chronic pelvic pain, dysmenorrhoea and infertility, substantially impairing quality of life. +3 more findings

• Lifestyle
• Treatments

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Prevalence of frailty and its association with cognition in preclinical Alzheimer’s disease: a cross-sectional analysis of baseline data from the A4 study

50/100 ✓ Peer-reviewed Treatments Age and Ageing

Key finding: Four thousand four hundred eighty-six participants were included (mean age 71.3 ± 4.7 years, 30% participants Aβ+, 59% female). +4 more findings

• Early Stage

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Druggable Pathophysiologic Targets in Alzheimer Disease: From Amyloid and Tau to Biomarker-Guided Multimodal Therapy

28/100 ✓ Peer-reviewed Treatments Dementia and Neurocognitive Disorders

Key finding: In contrast, amyloid-β monoclonal antibodies have provided proof that biomarker-confirmed early AD can be slowed, although the magnitude of clinical benefit is modest, treatment is restricted to carefully selected patients, and amyloid-related imaging abnormalities require structured monitoring. +4 more findings

• Treatments
• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source