Newest studies

The gut-brain vascular axis in neuroinflammation

41/100 ✓ Peer-reviewed Disease mechanisms Seminars in immunology

Key finding: Microbial dysbiosis is reported in several inflammatory intestinal diseases characterized by the impairment of the gut epithelial and vascular barriers, defined as leaky gut, and it is reported as a potential danger condition associated with the development of metabolic, inflammatory and neurodegenerative diseases.

• Brain Biology

Full summary, score breakdown and related studies → Original source

A History of Repeated Alcohol Intoxication Promotes Cognitive Impairment and Gene Expression Signatures of Disease Progression in the 3xTg Mouse Model of Alzheimer's Disease

41/100 ✓ Peer-reviewed Genetics eNeuro

Key finding: We observed a broad dysregulation of gene expression that involves neuronal excitability, neurodegeneration, and inflammation, including interferon genes. +2 more findings

• Genetics
• Brain Biology
• Lifestyle

Full summary, score breakdown and related studies → Original source

Efficacy and safety of anti-amyloid-β monoclonal antibodies in current Alzheimer's disease phase III clinical trials: A systematic review and interactive web app-based meta-analysis

79/100 ✓ Peer-reviewed Treatments Ageing research reviews

Key finding: The risk-benefit profile of anti-Aβ monoclonal antibodies (mAbs) in Alzheimer's disease (AD) remains unclear, especially concerning their safety and overall effects on AD progression and cognitive function. +3 more findings

• Treatments
• Clinical Trials
• Side Effects

Full summary, score breakdown and related studies → Original source

Developing a machine learning model for detecting depression, anxiety, and apathy in older adults with mild cognitive impairment using speech and facial expressions: A cross-sectional observational study

52/100 ✓ Peer-reviewed Digital health tools International journal of nursing studies

Key finding: The machine learning model developed in this study demonstrated strong classification performance in detecting and differentiating depression, anxiety, and apathy. +2 more findings

• Digital Tools
• Early Stage

Full summary, score breakdown and related studies → Original source

APOE genotypes modify the obesity paradox in dementia

41/100 ✓ Peer-reviewed Genetics Journal of neurology, neurosurgery, and psychiatry

Key finding: Obesity was associated with cognitive decline in early elderly cognitively normal individuals without APOE4, especially those with APOE2. +4 more findings

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

FDA Converts Novel Alzheimer's Disease Treatment to Traditional Approval

14/100 ⚠ Regulatory decision — not a study Treatments U.S. Food and Drug Administration

Key finding: Based on the Clarity AD Phase 3 trial (n=1,795) showing statistically significant slowing of cognitive/functional decline over 18 months vs placebo +2 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Passive Alzheimer's immunotherapy: A promising or uncertain option?

48/100 ✓ Peer-reviewed Treatments Ageing research reviews

Key finding: Two antibodies, donanemab and lecanemab, have demonstrated clinical efficacy, but these results remain uncertain. +1 more finding

• Treatments
• Clinical Trials
• Brain Scans

Full summary, score breakdown and related studies → Original source

Proteomics of brain, CSF, and plasma identifies molecular signatures for distinguishing sporadic and genetic Alzheimer's disease

52/100 ✓ Peer-reviewed TREM2 and immune genetics Science translational medicine

Key finding: Here, we present a proteomic study analyzing 1305 proteins in brain tissue, cerebrospinal fluid (CSF), and plasma from patients with sporadic AD, TREM2 risk variant carriers, patients with autosomal dominant AD (ADAD), and healthy individuals. +3 more findings

• Genetics
• Biomarkers

Full summary, score breakdown and related studies → Original source

Riding the merry-go-round of racial disparities in ADRD research

45/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: With the rapid expansion of the aging population, the burden of Alzheimer's disease related dementias (ADRD) is anticipated to increase in racialized and minoritized groups who are at disproportionately higher risk. +1 more finding

• Health Equity

Full summary, score breakdown and related studies → Original source

Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies

73/100 ✓ Peer-reviewed Brain tissue and pathology Brain : a journal of neurology

Key finding: In LATE-NC individuals, progression along data-driven stages was positively associated with age, but negatively associated with age in individuals with FTLD-TDP. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Effects of Exercise Alone or Combined With Cognitive Training and Vitamin D Supplementation to Improve Cognition in Adults With Mild Cognitive Impairment: A Randomized Clinical Trial

83/100 ✓ Peer-reviewed Prevention trials JAMA network open

Key finding: In this clinical trial, older adults with MCI receiving aerobic-resistance exercises with sequential computerized cognitive training significantly improved cognition, although some results were inconsistent. +4 more findings

• Clinical Trials
• Lifestyle
• Early Stage

Full summary, score breakdown and related studies → Original source

Sleep Architecture, Obstructive Sleep Apnea, and Cognitive Function in Adults

80/100 ✓ Peer-reviewed Long-term cohort studies JAMA network open

Key finding: Good sleep is essential for health, yet associations between sleep and dementia risk remain incompletely understood. +3 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

Effects of Meditation Training and Non-Native Language Training on Cognition in Older Adults: A Secondary Analysis of a Randomized Clinical Trial

65/100 ✓ Peer-reviewed Treatments JAMA network open

Key finding: Among 137 randomized participants, 2 were excluded for not meeting eligibility criteria, leaving 135 (mean [SD] age, 69.3 [3.8] years; 83 female [61%]) eligible for analysis. +2 more findings

• Clinical Trials

Full summary, score breakdown and related studies → Original source

TRAILBLAZER-ALZ 4: Topline Study Results Directly Comparing Donanemab to Aducanumab on Amyloid Lowering in Early, Symptomatic Alzheimer's Disease

62/100 ✓ Peer-reviewed Treatments BJPsych Open

Key finding: This study provides the first active comparator data on amyloid plaque clearance in patients with early symptomatic AD. +1 more finding

• Treatments
• Clinical Trials
• Brain Biology

Full summary, score breakdown and related studies → Original source

Economic burden of comorbid insomnia in 5 common medical disease subgroups

57/100 ✓ Peer-reviewed Costs and economics Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

Key finding: Sample sizes for individuals with comorbid insomnia ranged from 23,168 (T2DM) to 3,015 (ADRDs). +4 more findings

• Policy

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Associations between air pollution and mental health service use in dementia: a retrospective cohort study

68/100 ✓ Peer-reviewed Risk factors BMJ mental health

Key finding: In the first year of follow-up, increased exposure to all air pollutants was associated with an increase in the use of CMHTs in a dose-response manner. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

A Novel Formulation: Donepezil Patch

41/100 ✓ Peer-reviewed Treatments The Senior care pharmacist

Key finding: Prevalence of dementia continues to increase with limited pharmacotherapy options available. +4 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Human brain single nucleus cell type enrichments in neurodegenerative diseases

16/100 ⚠ Preprint — not yet peer-reviewed Genetics medRxiv : the preprint server for health sciences

Key finding: We were able to identify significant immune-related cell types in the brain across three major neurodegenerative diseases: Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Parkinson's Diseases.

• Genetics

Scored 20 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Advances in amyloid-targeting monoclonal antibodies for Alzheimer's disease: clinical and public health issues

40/100 ✓ Peer-reviewed Treatments Expert review of neurotherapeutics

Key finding: Alzheimer's disease (AD) is a major global public health challenge. +4 more findings

• Treatments

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Palliative care to support the needs of adults with neurological disease

43/100 ✓ Peer-reviewed End-of-life care The Lancet. Neurology

Key finding: Palliative care focuses on improving quality of life for people with serious illness and their families by addressing this multidimensional suffering. +4 more findings

• End-of-Life Care

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Estimates of diagnosed dementia prevalence and incidence among diverse beneficiaries in traditional Medicare and Medicare Advantage

45/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring

Key finding: The diagnosed dementia incidence rate was also lower in MA (2.50%; 95% CI: 2.50 to 2.50) compared to TM (2.99%; 95% CI: 2.99 to 2.99). +2 more findings

• Risk Factors
• Health Equity
• Policy

Full summary, score breakdown and related studies → Original source

Development and validation of a dementia risk score in the UK Biobank and Whitehall II cohorts

57/100 ✓ Peer-reviewed Long-term cohort studies BMJ mental health

Key finding: Current dementia risk scores have had limited success in consistently identifying at-risk individuals across different ages and geographical locations. +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Correlation between insulin-degrading enzyme versus total tau and selected cytokines in patients with Alzheimer´s disease compared to non-demented controls

33/100 ✓ Peer-reviewed Tau biomarkers Neuro endocrinology letters

Key finding: It has been increasingly recognized that the pathological progress of Alzheimer´s disease (AD) is connected to metabolic function and inflammation. +3 more findings

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Integrated single-cell analysis-based classification of vascular mononuclear phagocytes in mouse and human atherosclerosis

52/100 ✓ Peer-reviewed TREM2 and immune genetics Cardiovascular research

Key finding: Accumulation of mononuclear phagocytes [monocytes, macrophages, and dendritic cells (DCs)] in the vessel wall is a hallmark of atherosclerosis. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Association Between Acute Myocardial Infarction and Cognition

63/100 ✓ Peer-reviewed Disparities JAMA neurology

Key finding: This cohort study using pooled data from 6 cohort studies found that incident MI was not associated with a decrease in global cognition, memory, or executive function at the time of the event compared with no MI but was associated with faster declines in global cognition, memory, and executive function over time. +4 more findings

Full summary, score breakdown and related studies → Original source