Newest studies

Apolipoprotein E Polymorphisms in Andean Population of Jujuy, Argentina

50/100 ✓ Peer-reviewed Genetics Journal of Alzheimer's disease reports

Key finding: The pleiotropic nature of the apolipoprotein E (APOE) gene is associated with complex diseases in different populations. +1 more finding

• Genetics

Full summary, score breakdown and related studies → Original source

Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid β aggregates in vivo in a mouse model of Alzheimer's disease

45/100 ✓ Peer-reviewed Drug development Molecular neurodegeneration

Key finding: Considering these results, combination of mitochondria-targeted compounds with other anti-amyloid beta or anti-tau therapies hold promise as neuroprotective drugs for the prevention and/or treatment of AD. +1 more finding

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Racial and Ethnic Differences in the Population-Attributable Fractions of Alzheimer Disease and Related Dementias

79/100 ✓ Peer-reviewed Disparities Neurology

Key finding: Among 91,881 participants (mean age 59.3 at baseline, 55.0% female participants), 16,507 incident ADRD cases were identified from Medicare claims (1999-2016, mean follow-up 9.3 years). +4 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source

Metformin ameliorates mitochondrial damage induced by C9orf72 poly(GR) via upregulating AKT phosphorylation

43/100 ✓ Peer-reviewed Drug development Journal of cellular biochemistry

Key finding: In this study, we observed that (GR)50 conferred significant mitochondria damage and cytotoxicity. +2 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Presenilin Gene Mutation-associated Psychosis: Phenotypic Characteristics and Clinical Implications

50/100 ✓ Peer-reviewed Risk genes beyond APOE Alzheimer disease and associated disorders

Key finding: Thirty-three articles describing 52 individuals were included in the review, as well as one other study that provided limited information pertaining to an additional 21 cases. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Effect of computerized cognitive training on mood, cognition, and serum brain-derived neurotrophic factor level in late-life depression - a pilot randomized controlled trial

77/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in psychiatry

Key finding: Our sample had a mean age of 66.8 (SD = 5.3) years, a mean HAM-D score of 19.4 (SD = 7.5), and a mean PHQ-9 score of 18.0 (SD = 6.3). +4 more findings

• Clinical Trials
• Lifestyle
• Digital Tools

Full summary, score breakdown and related studies → Original source

Combining Glial Fibrillary Acidic Protein and Neurofilament Light Chain for the Diagnosis of Major Depressive Disorder

43/100 ✓ Peer-reviewed Biomarkers Analytical chemistry

Key finding: Analysis of real serum samples showed that the concentration ratio of GFAP to NFL, which is associated with the relative degree of brain inflammation and neurodegeneration, is suitable for not only distinguishing MDD from healthy individuals but also specifically distinguishing MDD from Alzheimer's disease and cerebral thrombosis.

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations

43/100 ✓ Peer-reviewed Treatments The Journal of experimental medicine

Key finding: We found that reductions in amyloid and neuritic dystrophy during acute treatment were accompanied by microglial and astrocytic activation, and microglial recruitment to plaques and adoption of an aducanumab-specific pro-phagocytic and pro-degradation transcriptomic signature, indicating a role for microglia in aducanumab-mediated Aβ clearance. +1 more finding

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Design and Feasibility Analysis of a Smartphone-Based Digital Cognitive Assessment Study in the Framingham Heart Study

71/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of the American Heart Association

Key finding: A smartphone application collected 2 modalities of cognitive data, digital voice and screen-based behaviors, from the FHS (Framingham Heart Study) multigenerational Generation 2 (Gen 2) and Generation 3 (Gen 3) cohorts. +4 more findings

• Digital Tools
• Diagnosis

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Comparing Cognitive Tests and Smartphone-Based Assessment in 2 US Community-Based Cohorts

52/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of the American Heart Association

Key finding: A total of 406 FHS (Framingham Heart Study) and 59 BHS (Bogalusa Heart Study) participants with traditional neuropsychological tests and digital assessments using the Defense Automated Neurocognitive Assessment (DANA) smartphone protocol were included. +4 more findings

• Diagnosis
• Digital Tools

Full summary, score breakdown and related studies → Original source

TREM2 variants that cause early dementia and increase Alzheimer's disease risk affect gene splicing

45/100 ✓ Peer-reviewed Genetics Brain

Key finding: The D134G TREM2 variant works mainly by causing skipping of exon 3, mimicking a splice-site mutation +3 more findings

• Genetics

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Fully synthetic phosphorylated Tau181, Tau217, and Tau231 calibrators for Alzheimer's disease diagnosis

41/100 ✓ Peer-reviewed Biomarkers Frontiers in aging neuroscience

Key finding: By employing the hybridoma technique, 49 mAbs recognizing Tau (1-22), nine mAbs targeting p-Tau231, one mAb targeting p-Tau217, and two mAbs targeting p-Tau181 were developed. +4 more findings

• Diagnosis

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APOE -ε4 allele[s]-associated adverse events reported from placebo arm in clinical trials for Alzheimer's disease: implications for anti-amyloid beta therapy

66/100 ✓ Peer-reviewed Treatments Frontiers in dementia

Key finding: APOE -ε4 allele[s] is a risk factor for Alzheimer's disease (AD) and Amyloid-Related Imaging Abnormalities (ARIA) in anti-amyloid beta therapy, and is also associated with cerebrovascular risk factors such as hyperlipidemia or atherosclerosis. +3 more findings

• Treatments
• Clinical Trials
• Genetics

Full summary, score breakdown and related studies → Original source

Scalable plasma and digital cognitive markers for diagnosis and prognosis of Alzheimer's disease and related dementias

60/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Combinations of plasma and digital cognitive markers show promise for scalable diagnosis and prognosis of ADRD.

• Diagnosis
• Treatments
• Biomarkers

Full summary, score breakdown and related studies → Original source

Alzheimer and Parkinson diseases, frontotemporal lobar degeneration and amyotrophic lateral sclerosis overlapping neuropathology start in the first two decades of life in pollution exposed urbanites and brain ultrafine particulate matter and industrial nanoparticles, including Fe, Ti, Al, V, Ni, Hg, Co, Cu, Zn, Ag, Pt, Ce, La, Pr and W are key players. Metropolitan Mexico City health crisis is in progress

45/100 ✓ Peer-reviewed Risk factors Frontiers in human neuroscience

Key finding: Metropolitan Mexico City (MMC) forensic autopsies strongly suggest that anthropogenic UFPM and industrial NPs reach the brain through the nasal/olfactory, lung, gastrointestinal tract, skin, and placental barriers. +2 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

How promising are the latest monoclonal antibodies targeting amyloid-β for the treatment of early Alzheimer's disease?

34/100 ✓ Peer-reviewed Drug development Expert opinion on emerging drugs

Key finding: Monoclonal antibodies targeting amyloid-β are the first disease-modifying treatments for Alzheimer disease to have received FDA-approval. +3 more findings

• Treatments

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Immediate Reactions to Alzheimer Biomarker Disclosure in Cognitively Unimpaired Individuals in a Global Truncated Randomized Trial

56/100 ✓ Peer-reviewed Treatments Neurology. Clinical practice

Key finding: Participants age 60-85 years deemed cognitively unimpaired were disclosed an elevated or not elevated brain amyloid result by a certified clinician. +4 more findings

• Clinical Trials
• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Cholinesterase inhibitors-associated torsade de pointes/QT prolongation: a real-world pharmacovigilance study

41/100 ✓ Peer-reviewed Treatments Frontiers in pharmacology

Key finding: 557 cases of TdP/QT prolongation related to 3 ChEIs were searched by SMQ. +4 more findings

• Treatments

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Effects of APOE2 and APOE4 on brain microstructure in older adults: modification by age, sex, and cognitive status

43/100 ✓ Peer-reviewed Genetics Alzheimer's research & therapy

Key finding: Among CN, APOE4 carriers showed lower entorhinal cortex neurite density than non-carriers, whereas APOE2 carriers showed lower cingulum neurite density than non-carriers. +4 more findings

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Blood Biomarkers of Alzheimer's Disease and Cognition: A Literature Review

59/100 ✓ Peer-reviewed Biomarkers Biomolecules

Key finding: The reviewed studies are heterogeneous, varying in design and population (cognitively unimpaired, cognitively impaired, or mixed populations), and show results that are sometimes conflicting. +2 more findings

• Biomarkers

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Interventions to Reduce Loneliness in Community-Living Older Adults: a Systematic Review and Meta-analysis

82/100 ✓ Peer-reviewed Risk factors Journal of general internal medicine

Key finding: A total of 5971 titles were reviewed and 60 studies were included in the analysis, 36 RCTs and 24 observational studies. +4 more findings

• Lifestyle

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Machine Learning Models of Polygenic Risk for Enhanced Prediction of Alzheimer Disease Endophenotypes

51/100 ✓ Peer-reviewed Biomarkers Neurology. Genetics

Key finding: We found that ML-PRS approaches improved upon standard PRS for prediction of AD endophenotypes, partly related to improved accounting for nonlinear effects of genetic susceptibility alleles. +2 more findings

• Genetics

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The glymphatic system and cerebral small vessel disease

43/100 ✓ Peer-reviewed Vascular contributions Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Key finding: Cerebral small vessel disease and glymphatic dysfunction are anatomically connected and significant risk factors are shared between the two. +4 more findings

• Other Dementias
• Risk Factors

Full summary, score breakdown and related studies → Original source

Modulation of Tau Pathology in Alzheimer's Disease by Dietary Bioactive Compounds

43/100 ✓ Peer-reviewed Drug development International journal of molecular sciences

Key finding: Evidence suggests that the accumulation and aggregation of tau cause synaptic dysfunction and neuronal degeneration.

• Brain Biology
• Lifestyle

Full summary, score breakdown and related studies → Original source

Orchestration of Genetic Alterations in PSEN1 and PSEN2 Genes in Development of Alzheimer's Disease through Computational Analysis

43/100 ✓ Peer-reviewed Risk genes beyond APOE Global medical genetics

Key finding: AD is a progressive disease, where in early stages there is mild memory loss and in late-stage patient loses the ability to carry on a conversation. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source