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Sleep Architecture, Obstructive Sleep Apnea, and Cognitive Function in Adults
Pase MP, Harrison S, Misialek JR, Kline CE, Cavuoto M, Baril AA, Yiallourou S, Bisson A et al.. JAMA network open, 2023-07-03
Topic: Risk, prevention and care in population studies
Importance Good sleep is essential for health, yet associations between sleep and dementia risk remain incompletely understood. The Sleep and Dementia Consortium was established to study associations between polysomnography (PSG)-derived sleep and the risk of dementia and related cognitive and brain magnetic resonance imaging endophenotypes. Objective To investigate association of sleep architecture and obstructive sleep apnea (OSA) with cognitive function in the Sleep and Dementia Consortium.
Key findings
- The Sleep and Dementia Consortium was established to study associations between polysomnography (PSG)-derived sleep and the risk of dementia and related cognitive and brain magnetic resonance imaging endophenotypes.
- Objective To investigate association of sleep architecture and obstructive sleep apnea (OSA) with cognitive function in the Sleep and Dementia Consortium.
- Design, setting, and participants The Sleep and Dementia Consortium curated data from 5 population-based cohorts across the US with methodologically consistent, overnight, home-based type II PSG and neuropsychological assessments over 5 years of follow-up: the Atherosclerosis Risk in Communities study, Cardiovascular Health Study, Framingham Heart Study (FHS), Osteoporotic Fractures in Men Study, and Study of Osteoporotic Fractures.
- Sleep metrics were harmonized centrally and then distributed to participating cohorts for cohort-specific analysis using linear regression; study-level estimates were pooled in random effects meta-analyses.
Why it matters
This consortium study investigated how sleep architecture and obstructive sleep apnea relate to cognitive function across five population-based cohorts. It examines associations with cognition but does not test whether treating sleep problems prevents dementia.
Study details
- Study designmeta-analysis
- Participants5,946
- Effect size31.5%; 16.9% to 28.9%
- Evidence strengthHigh
How this study scored 80/100
Published in a leading specialty journal, and it is a meta-analysis pooling many studies.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (JAMA network open) |
| Journal's citation record | 2 / 4 | JAMA Network Open: journal h-index 235 (OpenAlex, 2026-10-29) |
| Study design | 12 / 12 | A meta-analysis pooling many studies |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 3 / 4 | 5,946 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | A review of other studies — randomisation is not credited here |
| Times cited | 5 / 7 | Cited 124 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 24.8 citations a year over 5 year(s) since 2023 |
| Impact for its field and year | 4 / 6 | Cited 18.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 9 other studies in this library |
| Still being cited | 3 / 4 | Cited 120 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Jayandra Jung Himali: h-index 57 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 13 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37462968) |
| Free to read | 2 / 2 | Free to read |
| Total | 80 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1001/jamanetworkopen.2023.25152
- PubMed: 37462968
- Original source →
- Free full text: JAMA Network Open →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Pase, M. P., Harrison, S., Misialek, JR., Kline, C. E., Cavuoto, M., Baril, A. A., et al. (2023). Sleep Architecture, Obstructive Sleep Apnea, and Cognitive Function in Adults. JAMA network open. https://doi.org/10.1001/jamanetworkopen.2023.25152
Vancouver
Pase MP, Harrison S, Misialek JR, Kline CE, Cavuoto M, Baril AA, et al. Sleep Architecture, Obstructive Sleep Apnea, and Cognitive Function in Adults. JAMA network open. 2023. doi:10.1001/jamanetworkopen.2023.25152. PMID: 37462968.
BibTeX
@article{pase2023-37462968,
author = {Pase, M. P. and Harrison, S. and Misialek, JR. and Kline, C. E. and Cavuoto, M. and Baril, A. A. and Yiallourou, S. and Bisson, A. and others},
title = {{Sleep Architecture, Obstructive Sleep Apnea, and Cognitive Function in Adults}},
journal = {JAMA network open},
year = {2023},
doi = {10.1001/jamanetworkopen.2023.25152},
pmid = {37462968},
url = {https://doi.org/10.1001/jamanetworkopen.2023.25152}
}
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