Newest studies

Exposure to Air Pollutants and Lewy Body and Parkinson Disease-Related Dementias

77/100 ✓ Peer-reviewed Risk factors JAMA network open

Key finding: Among 2 184 847 Danish citizens aged between 65 and 95 years, there were 3024 individuals with DLB (mean [SD] age, 78 [6], 1894 [62.6%] male) and 3808 with PDD (mean [SD] age, 78 [6], 2400 [63.0%] male) who were matched with 30 240 and 38 080 controls, respectively. +4 more findings

• Other Dementias
• Risk Factors

Full summary, score breakdown and related studies → Original source

Balancing Speed and Sensitivity: Echo-Planar Accelerated MRI for ARIA-H Screening in Anti-Aβ Therapeutics

45/100 ✓ Peer-reviewed Treatments Investigative radiology

Key finding: Their results demonstrate that significant scan time reductions-up to 86%-can be achieved without substantial loss in diagnostic accuracy, particularly for accelerated GRE. +1 more finding

• Treatments
• Side Effects
• Diagnosis

Full summary, score breakdown and related studies → Original source

Exceptional Longevity Modifying Allele APOE2 Promotes DNA Signaling Pathways Resisting Cellular Senescence in Human Neurons

45/100 ✓ Peer-reviewed Genetics Aging cell

Key finding: Single-cell RNA sequencing revealed APOE4-specific gene expression signatures associated with AD, whereas APOE2 GABAergic neurons were enriched for DNA repair and signaling pathways. +4 more findings

• Genetics
• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

Association of plasma biomarkers with amyloid and tau PET in pre-dementia stages

55/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Comparing those having MCI, both CU and SCD participants had significantly lower amyloid PET standardized uptake value ratio (SUVR) (p < 0.001; p = 0.005). +3 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Physical activity, aerobic fitness, and AD blood biomarkers: The IGNITE study

61/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Greater MVPA (β = -0.107; p = 0.013) and CRF (β = -0.114; p = 0.027) were associated with lower NfL, but not Aβ PET, p-tau217, Aβ1-42/1-40, or GFAP. +3 more findings

• Biomarkers
• Lifestyle

Full summary, score breakdown and related studies → Original source

Does inflammatory bowel disease play a role in cognitive decline? A systematic review

49/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Crohn's & colitis

Key finding: IBD is associated with CI and increased dementia risk, with biologics potentially mitigating neuroinflammation-related decline. +3 more findings

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Stakeholder Perspectives on Integrating ADEPT Into End‐Of‐Life Care for Nursing Home Residents With Dementia: A Qualitative Descriptive Study

26/100 ✓ Peer-reviewed End-of-life care International Journal of Older People Nursing

Key finding: Current processes for identifying hospice-eligible residents rely on regular assessments and interdisciplinary collaboration but reveal significant gaps, including delays in referrals and inconsistent practices. +4 more findings

• Care Services
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Dementia and postoperative outcomes in older adults: national estimates and mechanistic pathways from a US cohort study

50/100 ✓ Peer-reviewed Clinical safety Age and Ageing

Key finding: Among 547 310 older adults undergoing surgery, 43 041 (7·9%) had preoperative dementia. +4 more findings

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Delirium: more than a marker of baseline vulnerability

55/100 ✓ Peer-reviewed Clinical safety Age and Ageing

Key finding: Across several cohorts, delirium is emerging as an important prognostic signal, independent of chronic markers of baseline morbidity, that identifies patients at markedly increased risk of death or future dementia. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Effects of α‐synuclein pathology on synaptic dysfunction and clinical outcomes in normal aging

43/100 ✓ Peer-reviewed Disease mechanisms Alzheimer s & Dementia

Key finding: α -Syn positivity was detected in 9% of CU individuals, a lower rate than in clinically impaired participants with AD (16%) and LBD diagnoses (81%). +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Astrocytes in Brain Aging and Neurodegeneration: Cellular Mechanisms and Interventional Strategies

37/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Neurochemistry

Key finding: The increase in senescent cells, including glial cells in the brain, is a general feature of normal aging and has been associated with age-related pathologies. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Ginsenoside Rh2 Alleviates Alzheimer Disease Models via Effects on Ferroptosis‐Related Neuroinflammation

33/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Biochemical and Molecular Toxicology

Key finding: Our results demonstrated that Rh2 treatment significantly enhanced the viability of N2a cells and ameliorated mitochondrial membrane potential dysregulation. +1 more finding

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Systemic delivery of synapsin‐promoted caveolin‐1 overexpression ameliorates pathological TDP‐43–induced cognitive decline and neurodegenerative changes

38/100 ✓ Peer-reviewed Brain tissue and pathology Alzheimer s & Dementia

Key finding: SynCav1 exerted robust neuroprotective effects on cognition. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Sex-Based Differences in Perioperative Brain Health Outcomes

57/100 ✓ Peer-reviewed Risk genes beyond APOE A&A Practice

Key finding: UNDERLYING BIOLOGICAL MECHANISMS PNDs result from a complex interplay of multiple biological, genetic, and environmental factors (Table 1). +4 more findings

• Brain Biology

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Spinal microglia are dysregulated in a rat model of Pompe disease

27/100 ✓ Peer-reviewed Risk genes beyond APOE Physiology

Key finding: Dysfunctional GAA results in widespread glycogen accumulation leading to muscle weakness, cardiovascular and breathing problems and premature death. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Research progress on ferroptosis mediated by ferritinophagy in Alzheimer′s disease

27/100 ✓ Peer-reviewed Risk genes beyond APOE Shengming kexue

Key finding: Dysregulated ferritinophagy-mediated ferroptosis is a pivotal AD pathogenic target. +4 more findings

Full summary, score breakdown and related studies → Original source

0076 Effect of a Tryptophan Enriched Diet on Mood, Cognition, Sleep and Their Associated Neurotransmitters/Hormones in a Mouse Model of Down Syndrome

31/100 ✓ Peer-reviewed Down syndrome and Alzheimer's SLEEP

Key finding: Our study is the first one showing that dietary supplements improve cognition and sleep in a mouse model of DS.

• Lifestyle
• Down Syndrome
• Brain Biology

Full summary, score breakdown and related studies → Original source

B31-13 Circadian Rest-Activity Rhythm and Alzheimer’s Disease Biomarkers in Adults With Down Syndrome

44/100 ✓ Peer-reviewed Down syndrome and Alzheimer's American Journal of Respiratory and Critical Care Medicine

Key finding: These findings suggest that circadian rhythm disruption as measured via 24-hour RAR is associated with plasma and imaging biomarkers of AD in DS. +4 more findings

• Biomarkers
• Down Syndrome

Full summary, score breakdown and related studies → Original source

Sleep Apnea as a Modifiable Risk Factor for Cognitive Decline and Dementia: Implications for Clinical Practice and Public Health

31/100 ✓ Peer-reviewed Risk factors Journal of Public Health and Primary Care

Key finding: Obstructive sleep apnea (OSA), a prevalent sleep-disordered breathing condition, is increasingly recognized as a modifiable risk factor for cognitive decline and dementia, including Alzheimer’s disease and vascular dementia.

• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Developing machine learning-enhanced WHODAS 2.0 short forms for persons with dementia

53/100 ✓ Peer-reviewed Digital health tools Journal of the Formosan Medical Association

Key finding: Both ML short forms showed high internal consistency (α = 0.96 for ML-WHODAS-16 and 0.93 for ML-WHODAS-10) and excellent concurrent validity with the full WHODAS-32 (r = 0.98 for both). +4 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source

Sleep and daily pain intensity among Black and White dementia caregivers

44/100 ✓ Peer-reviewed Disparities Alzheimer s & Dementia

Key finding: Black caregivers reported shorter sleep duration but lower daily pain than White caregivers. +4 more findings

• Lifestyle
• Caregiving

Full summary, score breakdown and related studies → Original source

Speech‐based digital cognitive assessment for clinical trials: Detecting cognitive impairment stages and AD biomarker relations across European cohorts

56/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer s & Dementia

Key finding: SB-C significantly differentiated cognitively unimpaired and impaired groups (P < 0.001), correlated with standard cognitive measures, and showed moderate-to-high area under the curve (0.56-0.82) for classifying biomarker positivity, with strongest results in BioFINDER-Primary Care. +1 more finding

• Diagnosis
• Biomarkers

Full summary, score breakdown and related studies → Original source

Treating dementia with brain amyloid medications

34/100 ✓ Peer-reviewed Treatments Canadian Family Physician

Key finding: Are amyloid-targeting monoclonal antibodies safe and effective for mild cognitive impairment (MCI) or Alzheimer disease? +1 more finding

• Treatments

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Amyloid pathology and modifiable risk factors in cognitive decline among cognitively unimpaired older adults

53/100 ✓ Peer-reviewed Treatments The Journal of Prevention of Alzheimer s Disease

Key finding: Significant interactions between amyloid status and modifiable risk factors were observed for diabetes (adjusted β = -0.206, p = 0.032), high cholesterol (adjusted β = -0.155, p < 0.001), and physical inactivity (adjusted β = -0.161, p = 0.046), indicating combined effects rather than additive effects on cognitive decline among Aβ+ individuals. +4 more findings

• Risk Factors
• Early Stage
• Prevention

Full summary, score breakdown and related studies → Original source

Appropriate use recommendations of the Spanish Society of Neurology’s Behavioural Neurology and Dementia Study Group on anti-amyloid antibodies in the treatment of Alzheimer disease

32/100 ✓ Peer-reviewed Treatments Neurología (English Edition)

Key finding: The introduction of the first anti-amyloid mAb represents a paradigm shift in the management of AD, but is not free of challenges. +3 more findings

• Treatments

Full summary, score breakdown and related studies → Original source