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63/100

✓ Peer-reviewed alzhub usefulness score 63 out of 100. Disparities

Topic: Risk, prevention and care in population studies

Objective To assess whether incident MI is associated with changes in cognitive function after adjusting for pre-MI cognitive trajectories. Results The study included 30 465 adults (mean [SD] age, 64 [10] years; 56% female), of whom 1033 had 1 or more MI event, and 29 432 did not have an MI event. Overall, incident MI was not associated with an acute decrease in global cognition (-0.18 points; 95% CI, -0.52 to 0.17 points), executive function (-0.17 points; 95% CI, -0.53 to 0.18 points), or memory (0.62 points; 95% CI, -0.07 to 1.31 points). However, individuals with incident MI vs those without MI demonstrated faster declines in global cognition (-0.15 points per year; 95% CI, -0.21 to -0.10 points per year), memory (-0.13 points per year; 95% CI, -0.22 to -0.04 points per year), and executive function (-0.14 points per year; 95% CI, -0.20 to -0.08 points per year) over the years after MI compared with pre-MI slopes. The interaction analysis suggested that race and sex modified the degree of change in the decline in global cognition after MI (race × post-MI slope interaction term, P = .02; sex × post-MI slope interaction term, P = .04), with a smaller change in the decline over the years after MI in Black individuals than in White individuals (difference in slope change, 0.22 points per year; 95% CI, 0.04-0.40 points per year) and in females than in males (difference in slope change, 0.12 points per year; 95% CI, 0.01-0.23 points per year). Conclusions This cohort study using pooled data from 6 cohort studies found that incident MI was not associated with a decrease in global cognition, memory, or executive function at the time of the event compared with no MI but was associated with faster declines in global cognition, memory, and executive function over time. These findings suggest that prevention of MI may be important for long-term brain health.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Johansen, M. C., Ye, W., Gross, A., Gottesman, R. F., Han, D., Whitney, R., et al. (2023). Association Between Acute Myocardial Infarction and Cognition. JAMA neurology. https://doi.org/10.1001/jamaneurol.2023.1331

Vancouver

Johansen MC, Ye W, Gross A, Gottesman RF, Han D, Whitney R, et al. Association Between Acute Myocardial Infarction and Cognition. JAMA neurology. 2023. doi:10.1001/jamaneurol.2023.1331. PMID: 37252710.

BibTeX

@article{johansen2023-37252710,
  author  = {Johansen, M. C. and Ye, W. and Gross, A. and Gottesman, R. F. and Han, D. and Whitney, R. and Briceño, E. M. and Giordani, B. J. and others},
  title   = {{Association Between Acute Myocardial Infarction and Cognition}},
  journal = {JAMA neurology},
  year    = {2023},
  doi     = {10.1001/jamaneurol.2023.1331},
  pmid    = {37252710},
  url     = {https://doi.org/10.1001/jamaneurol.2023.1331}
}

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Key findings

Objective To assess whether incident MI is associated with changes in cognitive function after adjusting for pre-MI cognitive trajectories.
Results The study included 30 465 adults (mean [SD] age, 64 [10] years; 56% female), of whom 1033 had 1 or more MI event, and 29 432 did not have an MI event.
Overall, incident MI was not associated with an acute decrease in global cognition (-0.18 points; 95% CI, -0.52 to 0.17 points), executive function (-0.17 points; 95% CI, -0.53 to 0.18 points), or memory (0.62 points; 95% CI, -0.07 to 1.31 points).
However, individuals with incident MI vs those without MI demonstrated faster declines in global cognition (-0.15 points per year; 95% CI, -0.21 to -0.10 points per year), memory (-0.13 points per year; 95% CI, -0.22 to -0.04 points per year), and executive function (-0.14 points per year; 95% CI, -0.20 to -0.08 points per year) over the years after MI compared with pre-MI slopes.
The interaction analysis suggested that race and sex modified the degree of change in the decline in global cognition after MI (race × post-MI slope interaction term, P = .02; sex × post-MI slope interaction term, P = .04), with a smaller change in the decline over the years after MI in Black individuals than in White individuals (difference in slope change, 0.22 points per year; 95% CI, 0.04-0.40 points per year) and in females than in males (difference in slope change, 0.12 points per year; 95% CI, 0.01-0.23 points per year).

Why it matters

This study looked at whether having a heart attack was linked to changes in thinking and memory. It found that a heart attack was not linked to an immediate drop in cognition but was linked to faster decline over the years afterward, and it does not test any treatment or cure for Alzheimer's disease.

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Study details

Study designcohort study
Participants30
Evidence strengthModerate

How this study scored 63/100

Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (JAMA neurology)
Journal's citation record	2 / 4	JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29)
Study design	7 / 12	A cohort study following people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	3 / 5	2023 — within 6 year(s) of the newest study here
Sample size	1 / 4	30 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 62 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	12.4 citations a year over 5 year(s) since 2023
Impact for its field and year	4 / 6	Cited 11.2× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	1 / 6	Cited by 1 other studies in this library
Still being cited	3 / 4	Cited 56 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Deborah A. Levine: h-index 43 (OpenAlex, whole career)
Institution's track record	3 / 3	University of Washington: institution h-index 3,540 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 11 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 37252710)
Free to read	0 / 2	Behind a paywall — scores zero
Total	63 / 100	—

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