Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 20,026–20,050 of 27,380 studies, newest first · page 802 of 1096.
July 2011 25
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2011-07-21
Functional network disruption in the degenerative dementias
54/100 ✓ Peer-reviewed Getting a diagnosis The Lancet. Neurology
Key finding: These findings might have practical implications for diagnostic accuracy, allowing earlier detection of neurodegenerative diseases even at the presymptomatic stage, and tracking of disease progression.
Full summary, score breakdown and related studies → Original source
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2011-07-21
Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association
56/100 ✓ Peer-reviewed Prevention and risk Stroke
Key finding: This statement serves as an overall guide for practitioners to gain a better understanding of VCI and dementia, prevention, and treatment. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-07-20
Molecular chaperones in protein folding and proteostasis
41/100 ✓ Peer-reviewed Disease mechanisms Nature
Key finding: Recent advances suggest that an age-related decline in proteostasis capacity allows the manifestation of various protein-aggregation diseases, including Alzheimer's disease and Parkinson's disease.
Full summary, score breakdown and related studies → Original source
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2011-07-19
CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease
48/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: Fractalkine signaling, a pathway mediating the communication between microglia and neurons, is deficient in AD brains and down-regulated by amyloid-β. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-07-19
Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial
64/100 ✓ Peer-reviewed Caregiving Lancet (London, England)
Key finding: Decreases in depression scores at 13 weeks did not differ between 111 controls and 107 participants allocated to receive sertraline (mean difference 1·17, 95% CI -0·23 to 2·58; p=0·10) or mirtazapine (0·01, -1·37 to 1·38; p=0·99), or between participants in the mirtazapine and sertraline groups (1·16, -0·25 to 2·57; p=0·11); these findings persisted to 39 weeks. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-07-15
Efficacy of treating pain to reduce behavioural disturbances in residents of nursing homes with dementia: cluster randomised clinical trial
79/100 ✓ Peer-reviewed Clinical trials BMJ (Clinical research ed.)
Key finding: A systematic approach to the management of pain significantly reduced agitation in residents of nursing homes with moderate to severe dementia. +3 more findings
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2011-07-15
Evaluation of a calibrated (18)F-FDG PET score as a biomarker for progression in Alzheimer disease and mild cognitive impairment
45/100 ✓ Peer-reviewed Long-term cohort studies Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Key finding: Increasingly, clinical trials are being planned in patients with mild cognitive impairment (MCI) to prevent or delay the onset of dementia in Alzheimer disease (AD) by disease-modifying intervention. +3 more findings
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2011-07-15
Amyloid imaging with (18)F-florbetaben in Alzheimer disease and other dementias
54/100 ✓ Peer-reviewed Getting a diagnosis Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Key finding: When compared with the other groups, AD patients demonstrated significantly higher SUVRs (P Conclusion (18)F-florbetaben had high sensitivity for AD, clearly distinguished patients with FTLD from AD, and provided results comparable to those reported with (11)C-Pittsburgh Compound B in a variety of neurodegenerative diseases.
Full summary, score breakdown and related studies → Original source
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2011-07-13
Proinflammatory cytokines, sickness behavior, and Alzheimer disease
64/100 ✓ Peer-reviewed Caregiving Neurology
Key finding: Increased serum proinflammatory cytokines are associated with the presence of symptoms characteristic of sickness behavior, which are common neuropsychiatric features found in AD. +2 more findings
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2011-07-13
Hippocampal atrophy in first episode depression: a meta-analysis of magnetic resonance imaging studies
76/100 ✓ Peer-reviewed Hippocampus size on brain scans Journal of affective disorders
Key finding: Hippocampal volume loss in first episode depression is consistent with a neurodevelopmental model of depression, advocating hippocampal structure as a potential diagnostic neurobiomarker for depression. +1 more finding
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2011-07-12
Decreased brain stiffness in Alzheimer's disease determined by magnetic resonance elastography
40/100 ✓ Peer-reviewed Brain scans and imaging Journal of magnetic resonance imaging : JMRI
Key finding: 3D MRE of the brain can be performed reproducibly and demonstrates significantly reduced brain tissue stiffness in patients with AD. +4 more findings
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2011-07-11
Using positron emission tomography and florbetapir F18 to image cortical amyloid in patients with mild cognitive impairment or dementia due to Alzheimer disease
54/100 ✓ Peer-reviewed Genetics Archives of neurology
Key finding: It introduces criteria to determine whether an image is associated with an intermediate-to-high likelihood of pathologic AD or with having any identifiable cortical amyloid level above that seen in low-risk young controls. +2 more findings
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2011-07-11
Association between in vivo fluorine 18-labeled flutemetamol amyloid positron emission tomography imaging and in vivo cerebral cortical histopathology
49/100 ✓ Peer-reviewed Biomarkers Archives of neurology
Key finding: There was complete agreement between visual reads of ¹⁸F-flutemetamol PET scans (3 blinded readers with majority rule) and histology. +3 more findings
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2011-07-07
Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementation
64/100 ✓ Peer-reviewed Treatments American journal of medical genetics. Part A
Key finding: Compared to the placebo group, those individuals receiving the antioxidant supplement showed neither an improvement in cognitive functioning nor a stabilization of cognitive decline. +3 more findings
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2011-07-06
GBA-associated PD presents with nonmotor characteristics
53/100 ✓ Peer-reviewed Risk factors Neurology
Key finding: Especially nonmotor symptoms seem to be very common in GBA-PD. +1 more finding
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2011-07-01
Clinical amyloid imaging in Alzheimer's disease
55/100 ✓ Peer-reviewed Treatments The Lancet. Neurology
Key finding: The hypothesis that amyloid deposition is the leading cause of Alzheimer's disease (AD) is supported by findings in transgenic animal models and forms the basis of clinical trials of anti-amyloid agents.
Full summary, score breakdown and related studies → Original source
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2011-07-01
Structural neuroimaging studies in major depressive disorder. Meta-analysis and comparison with bipolar disorder
64/100 ✓ Peer-reviewed Hippocampus size on brain scans Archives of general psychiatry
Key finding: The meta-analyses revealed structural brain abnormalities in MDD that are distinct from those observed in BD. +4 more findings
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2011-07-01
Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model
36/100 ✓ Peer-reviewed Disease mechanisms Journal of neuropathology and experimental neurology
Key finding: Using fluorescent in situ hybridization to detect Arc messenger RNA, we found that rTg4510 mice have impaired hippocampal Arc expression both without stimulation and in response to environmental enrichment; this likely reflects the combination of functional impairments of existing neurons and loss of neurons. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-07-01
Emerging histomorphologic phenotypes of chronic traumatic encephalopathy in American athletes
40/100 ✓ Peer-reviewed Disease mechanisms Neurosurgery
Key finding: The emerging histomorphologic features of our CTE cohort may specify histologic criteria for CTE diagnosis, may identify emerging histologic variants of CTE and may facilitate more objective surveillance and accurate identification of sentinel CTE cases.
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2011-07-01
Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: Recommendations from the Alzheimer’s Association Research Roundtable Workgroup
55/100 ✓ Peer-reviewed Clinical safety Alzheimer s & Dementia
Key finding: Amyloid imaging related abnormalities (ARIA) have now been reported in clinical trials with multiple therapeutic avenues to lower amyloid-β burden in Alzheimer's disease (AD). +2 more findings
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2011-07-01
An update on the burden of cardiovascular disease risk factors in Jamaica: findings from the Jamaica Health and Lifestyle Survey 2007-2008
34/100 ✓ Peer-reviewed Prevention and risk The West Indian medical journal
Key finding: Prevalence estimates for traditional CVD risk factors were: hypertension, 25%; diabetes, 8%; hypercholesterolaemia, 12%; obesity, 25%; smoking 15%. +4 more findings
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2011-07-01
P3‐259: Geographic variation in mortality from dementia in the United States in 1999‐2006
25/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia
Key finding: Further research is needed to assess artifacts of diagnosis, certification or coding versus biological variation as possible causes of geographic variation to enhance utility of mortality data for disease monitoring and research.
Full summary, score breakdown and related studies → Original source
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2011-07-01
P3‐401: Impact of prescription drug coverage on use of anti‐dementia drugs
43/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer s & Dementia
Key finding: Multivariable analyses show increasing use within each insurance group is significant, yet the increasing rate between all the groups and the no cap intervention group is not statistically different.
Full summary, score breakdown and related studies → Original source
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2011-07-01
A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease
52/100 ✓ Peer-reviewed Brain tissue and pathology American journal of human genetics
Key finding: We found a missense mutation, c.1858G>A (p.Asp620Asn), in the VPS35 gene in all seven affected family members who are alive. +3 more findings
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2011-07-01
The roles of amyloid precursor protein (APP) in neurogenesis: Implications to pathogenesis and therapy of Alzheimer disease
41/100 ✓ Peer-reviewed Risk genes beyond APOE Cell adhesion & migration
Key finding: Excessive accumulation of Aβ, the main constituent of amyloid plaques, has been implicated in the etiology of Alzheimer's disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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