Newest studies

[Glucagon-like peptide-1 receptor agonists: a new pharmacological treatment option for psychiatric illnesses?]

43/100 ✓ Peer-reviewed Drug development Der Nervenarzt

Key finding: More severe side effects include pancreatitis, allergic reactions, renal function disorders and possibly an increased risk of thyroid cancer.

• Treatments

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Blood Biomarkers Reflect Dementia Symptoms and Are Influenced by Cerebrovascular Lesions

52/100 ✓ Peer-reviewed Biomarkers International journal of molecular sciences

Key finding: Bivariate analysis exhibited that all measured BM indicators were significantly associated with cognitive decline in patients without past stroke lesions. +2 more findings

• Biomarkers

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Phosphorylated tau 181 and 217 are elevated in serum and muscle of patients with amyotrophic lateral sclerosis

61/100 ✓ Peer-reviewed Biomarkers Nature communications

Key finding: Serum p-tau 181 and p-tau 217 were higher in AD and ALS patients compared to disease controls. +1 more finding

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Comparative risk of dementia in diabetic stroke patients prescribed SGLT2 vs. DPP-4 inhibitors: A propensity-matched retrospective cohort study

60/100 ✓ Peer-reviewed Vascular contributions Journal of Stroke and Cerebrovascular Diseases

Key finding: After propensity score matching, each group consisted of 15901 patients. +4 more findings

• Risk Factors

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Unmet Activities of Daily Living (ADL) Care Needs and Associated Risk Factors Among Older Adults with Dementia at the End of Life

28/100 ✓ Peer-reviewed End-of-life care Journal of Gerontological Social Work

Key finding: This paper examined the prevalence of and risk factors associated with unmet needs for activities of daily living (ADL) for older adults dying with dementia. +1 more finding

• End-of-Life Care
• Risk Factors

Full summary, score breakdown and related studies → Original source

Unlocking Cognitive Potential: Exploring a Virtual Environment for Cognitive Training in Healthy Aging and Mild Cognitive Impairment

33/100 ✓ Peer-reviewed Prevention trials IRBM

Key finding: Participants with MCI exhibited a significantly higher frequency of wandering and uncorrected orientation errors, compared to cognitively healthy older adults. +1 more finding

• Early Stage
• Lifestyle

Full summary, score breakdown and related studies → Original source

The interplay between age at menopause and synaptic integrity on Alzheimer’s disease risk in women

47/100 ✓ Peer-reviewed Disease mechanisms Science Advances

Key finding: Earlier estrogen depletion-via earlier menopause-has been associated with increased risk for Alzheimer's disease (AD). +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Sinomenine alleviates neuroinflammation in chronic cerebral hypoperfusion by promoting M2 microglial polarization and inhibiting neuronal pyroptosis via exosomal miRNA-223-3p

42/100 ✓ Peer-reviewed Inflammation and the immune system Acta Neuropathologica Communications

Key finding: Sinomenine (SINO), a natural alkaloid derived from traditional Chinese medicine, has shown significant anti-inflammatory and neuroprotective properties. +4 more findings

• Brain Biology

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Assessing Co‐Localization of ITM2B With Alzheimer's Disease and Limbic‐Predominant Age‐Related TDP ‐43 Encephalopathy Neuropathologic Changes

35/100 ✓ Peer-reviewed Brain tissue and pathology Neuropathology

Key finding: Mutations in the Integral membrane protein 2B (ITM2B) gene are linked to the development of familial British and Danish dementias, two relatively early-onset dementia disorders known also to be associated with Tau neurofibrillary tangles (NFTs). +1 more finding

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

The Effect of Hypertension on Cognitive Decline and Dementia: A Meta- Analysis

49/100 ✓ Peer-reviewed Risk factors Cardiology and Cardiovascular Medicine

Key finding: According to studies regarding hypertension, patients suffering from it showed a much higher risk score (38%) of cognitive impairment than normotensives. +2 more findings

• Risk Factors
• Treatments
• Brain Biology

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EEG-Based Dementia Classification Using CS-EMD Synchrony Features and Quantum Machine Learning

39/100 ✓ Peer-reviewed Digital health tools IEEE Transactions on Consumer Electronics

Key finding: On the other hand, quantum machine learning (QML), which combines the concepts of quantum computing and machine learning, has recently gained much attention with the rising anticipation that this emerging research field may provide significant advantages over classical methods. +1 more finding

• Digital Tools

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Assessing Cognition Remotely: Expanding the Reach of Cognitive Testing for Older Adults at Risk for Dementia in a Randomized Controlled Trial

46/100 ✓ Peer-reviewed Getting a diagnosis Canadian Geriatrics Journal

Key finding: Scores on the MoCA (p=.076), CFC2 (p=.053), and T-CogS (p=.281) were not statistically significantly different from baseline to post-intervention.

• Clinical Trials
• Diagnosis

Full summary, score breakdown and related studies → Original source

Correlation of magnetic resonance imaging parameters with montreal cognitive assessment-Indonesian (MOCA-INA) score in dementia patients at Prof. Dr. IGNG Ngoerah General Hospital, Denpasar, Bali, Indonesia

28/100 ✓ Peer-reviewed Getting a diagnosis The Egyptian Journal of Radiology and Nuclear Medicine

Key finding: Parameters such as clinical status, GCA scale, MTA scale, Fazekas scale, strategic infarction, Koedam score, stroke, hypertension, diabetes mellitus, dyslipidemia, and cardiovascular disease do not have significant correlations with MoCA-INA scores. +3 more findings

• Diagnosis
• Brain Scans
• Risk Factors

Full summary, score breakdown and related studies → Original source

Indocyanine Green Fluorescence Imaging in Prevention of Colorectal Anastomotic Leakage

60/100 ✓ Peer-reviewed Prevention and risk JAMA Surgery

Key finding: Among 1136 patients in the intention-to-treat population, 526 (46.3%) were female and 610 (53.7%) male; they had a mean (SD) age of 70 (11) years, body mass index of 28 (5), and age-adjusted Charlson Comorbidity Index of 5 (3). +4 more findings

• Prevention
• Brain Scans

Full summary, score breakdown and related studies → Original source

Cardiovascular diseases and risk of dementia in the general population

70/100 ✓ Peer-reviewed Prevention and risk European Journal of Preventive Cardiology

Key finding: Observationally, CVDs were associated with risk of all incident outcomes in meta-analyses, with hazard ratios up to 7.00 (95% confidence interval [CI]: 6.20, 7.92). +4 more findings

• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Plasma NfL, P-tau181, and P-tau181/Aβ42 Ratio in Predicting Mild Behavioral Impairment in Dementia-Free Multiethnic Asian Older Adults With Mixed Pathology in a 5-Year Clinical Cohort

44/100 ✓ Peer-reviewed Tau biomarkers The Journal of clinical psychiatry

Key finding: The underlying mechanisms of mild behavioral impairment (MBI), a marker for cognitive impairment and dementia, have remained unclear especially in a multiethnic Asian population. +3 more findings

• Biomarkers

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Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration

46/100 ✓ Peer-reviewed Disease mechanisms Autophagy

Key finding: In the present study, we found senescent aVICs exhibited impaired macroautophagy/autophagy as evidenced by compromised autophagy flux and immature autophagosomes. +1 more finding

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Structural variants linked to Alzheimer's disease and other common age-related clinical and neuropathologic traits

70/100 ✓ Peer-reviewed Genetics Genome medicine

Key finding: First, we mapped SVs across 81 AD risk loci and discovered 22 SVs in linkage disequilibrium (LD) with GWAS lead variants and directly associated with the phenotypes tested. +4 more findings

• Genetics
• Brain Biology

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Hospice Use Among Medicare Beneficiaries With Parkinson Disease and Dementia With Lewy Bodies

53/100 ✓ Peer-reviewed Lewy body dementia JAMA Network Open

Key finding: Of 11 327 324 Medicare beneficiaries enrolled in hospice between 2010 and 2020 who met eligibility criteria (mean [SD] age, 85.2 [7.5] years; 781 763 [63.0%] female), there were 958 182 (8.4%) with a primary diagnosis of AD, 232 864 (2.1%) with PD, and 49 340 (0.4%) with DLB. +4 more findings

• Other Dementias
• End-of-Life Care
• Policy

Full summary, score breakdown and related studies → Original source

Confounder adjustment in observational studies investigating multiple risk factors: a methodological study

64/100 ✓ Peer-reviewed Risk factors BMC Medicine

Key finding: A total of 162 studies were included, with 88 (54.3%) exploring potential risk factors and 74 (45.7%) examining specific risk factors. +4 more findings

• Risk Factors

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Use of Artificial Intelligence, Internet of Things, and Edge Intelligence in Long-Term Care for Older People: Comprehensive Analysis Through Bibliometric, Google Trends, and Content Analysis

52/100 ✓ Peer-reviewed Digital health tools Journal of Medical Internet Research

Key finding: A total of 6378 papers published between 2014 and 2023 were analyzed. +4 more findings

• Digital Tools
• Care Services

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Cardiovascular-kidney-metabolic syndrome and incidence of dementia among older adults

59/100 ✓ Peer-reviewed Getting a diagnosis The Journal of Prevention of Alzheimer s Disease

Key finding: The 2,641 participants had a mean (SD) age of 74 (2.8) years at baseline; 53 % were female, 36 % were of Black race, and had a range of baseline CKM: 3 % Stage 0 (no CKM), 4 % Stage 1 (excess/dysfunctional adiposity), 26 % Stage 2 (metabolic risk factors), 24 % Stage 3 (subclinical CVD and CKD), and 43 % Stage 4 (clinical CVD and CKD). +4 more findings

• Risk Factors

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Long‐Term Exposure to Non‐Steroidal Anti‐Inflammatory Medication in Relation to Dementia Risk

57/100 ✓ Peer-reviewed Prevention and risk Journal of the American Geriatrics Society

Key finding: During an average follow-up period of 14.5 years, a total of 9520 (81.1%) participants had used NSAIDs at any given time, and 2091 participants developed dementia. +4 more findings

• Risk Factors
• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Lecanemab for mild Alzheimer disease - is there a way forward?

43/100 ✓ Peer-reviewed Treatments Drugs in context

Key finding: This Editorial reviews data on the efficacy and adverse effects of lecanemab amongst individuals with mild Alzheimer disease. +2 more findings

• Treatments

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Developing a best-practice guide to support care for Aboriginal and Torres Strait Islander peoples living with cognitive impairment and dementia: Prioritising inclusivity, consensus-building and cultural values

37/100 ✓ Peer-reviewed End-of-life care SSM - Mental Health

Key finding: Stakeholders wanted a BPG that was: comprehensive, easy to follow and practical; incorporated cultural considerations and took account of the ongoing effects of colonisation. +4 more findings

Full summary, score breakdown and related studies → Original source