Newest studies

Lipid-associated macrophages' promotion of fibrosis resolution during MASH regression requires TREM2

54/100 ✓ Peer-reviewed TREM2 and immune genetics Proceedings of the National Academy of Sciences of the United States of America

Key finding: Comparing macrophage heterogeneity during MASH progression vs regression, we identified specific macrophage subpopulations that are critical for MASH/fibrosis resolution. +3 more findings

• Genetics

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Racial and ethnic disparities in potentially inappropriate medication use in patients with dementia

43/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society

Key finding: Compared to White participants, Black, Hispanic, and Asian participants reported taking fewer total medications (incidence rate ratio [IRR] ± standard error[SE] = 0.903 ± 0.017, 0.875 ± 0.021, and 0.912 ± 0.041, respectively, all p < 0.01). +4 more findings

• Health Equity
• Treatments

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The impact of physical exercise on neuroinflammation mechanism in Alzheimer's disease

56/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in aging neuroscience

Key finding: The findings underscore the potential of integrating physical exercise into comprehensive AD management strategies. +3 more findings

• Brain Biology
• Lifestyle

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Accelerometer-derived 'weekend warrior' physical activity pattern and brain health

63/100 ✓ Peer-reviewed Long-term cohort studies Nature aging

Key finding: However, whether the 'weekend warrior' pattern, characterized by concentrated moderate-to-vigorous PA (MVPA) over 1-2 days, is associated with brain health is unclear. +3 more findings

• Lifestyle

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C9orf72 dipeptides activate the NLRP3 inflammasome

46/100 ✓ Peer-reviewed Inflammation and the immune system Brain communications

Key finding: Poly-glycine-arginine also activated the inflammasome in organotypic hippocampal slice cultures, and immunofluorescence imaging demonstrated formation of inflammasome specks in response to poly-glycine-arginine. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Performance of plasma p-tau217 for the detection of amyloid-β positivity in a memory clinic cohort using an electrochemiluminescence immunoassay

53/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: Of 108 participants (age: 69 ± 6.5 years; 54.6% female) with paired samples obtained at time of LP, 64.8% (n = 70/108) had Aβ pathology detected (35 with Mild Cognitive Impairment and 35 with mild dementia). +1 more finding

• Biomarkers
• Care Services

Full summary, score breakdown and related studies → Original source

Single-Nucleus Landscape of Glial Cells and Neurons in Alzheimer's Disease

43/100 ✓ Peer-reviewed Genetics Molecular neurobiology

Key finding: Alzheimer's disease (AD) is a neurodegenerative disease with a projected significant increase in incidence. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Peripheral hearing loss at age 70 predicts brain atrophy and associated cognitive change

52/100 ✓ Peer-reviewed Risk factors Journal of neurology, neurosurgery, and psychiatry

Key finding: 111 out of 287 participants had hearing impairment. +4 more findings

• Risk Factors
• Brain Scans

Full summary, score breakdown and related studies → Original source

Single-nucleus multiome analysis of human cerebellum in Alzheimer's disease-related dementia

16/100 ⚠ Preprint — not yet peer-reviewed Genetics Research square

Key finding: Using peak-to-gene linkage analysis, we identified 431,834 significant linkages between gene expression and cell subtype-specific chromatin accessibility regions enriched for candidate cis-regulatory elements (cCREs). +1 more finding

• Genetics

Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy

46/100 ✓ Peer-reviewed Genetics Molecular neurodegeneration

Key finding: Our analysis of common SNVs and indels confirmed known genetic loci at MAPT, MOBP, STX6, SLCO1A2, DUSP10, and SP1, and further uncovered novel signals in APOE, FCHO1/MAP1S, KIF13A, TRIM24, TNXB, and ELOVL1. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Regional variation in diagnostic intensity of dementia among older U.S. adults: An observational study

48/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Crude new ADRD diagnosis rate ranged from 1.7 to 5.4 per 100 across HRRs. +4 more findings

• Diagnosis

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Prevalence of dementia diagnosis in Sweden by geographical region and sociodemographic subgroups: a nationwide observational study

45/100 ✓ Peer-reviewed Risk factors The Lancet Regional Health - Europe

Key finding: At the end of 2022, 3.7% (92,293/2,483,798) of people aged ≥62 years in Sweden had a dementia diagnosis from specialist care or drug prescriptions and varied from 0.6% in ages 62-69 to 14.8% in ages ≥90. +4 more findings

• Diagnosis

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Prognostic value of Alzheimer's disease plasma biomarkers in the oldest-old: a prospective primary care-based study

64/100 ✓ Peer-reviewed Biomarkers The Lancet regional health. Europe

Key finding: Higher levels of P-tau181 (HR = 1.32 [95% CI: 1.17-1.51]), NfL (HR = 1.19 [95% CI: 1.03-1.36]), and GFAP (HR = 1.36 [95% CI: 1.22-1.52]), and a lower Aβ42/Aβ40 ratio (HR = 0.80 [95% CI: 0.68-0.95]) were associated with an increased risk of progressing to clinically-diagnosed DAT. +1 more finding

• Biomarkers
• Care Services
• Diagnosis

Full summary, score breakdown and related studies → Original source

Tau pathology mediated the plasma biomarkers and cognitive function in patients with mild cognitive impairment

54/100 ✓ Peer-reviewed Biomarkers Experimental gerontology

Key finding: Glial fibrillary acidic protein (GFAP) and neurofilament light (NfL) are putative non-amyloid biomarkers indicative of ongoing inflammatory and neurodegenerative disease processes. +1 more finding

• Biomarkers
• Early Stage
• Brain Biology

Full summary, score breakdown and related studies → Original source

Dose-response relationship between computerized cognitive training and cognitive improvement

71/100 ✓ Peer-reviewed Cognitive tests and assessment NPJ digital medicine

Key finding: A mixed-effects model revealed significant Cognitive Index increases across most dose groups before reaching the optimal dose. +1 more finding

• Digital Tools
• Lifestyle

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Enhancing dementia risk screening with GAN-synthesized periodontal examination and general blood test data

52/100 ✓ Peer-reviewed Biomarkers Frontiers in neurology

Key finding: This study used measured data from 108 participants and the synthesized data generated from the measured data. +4 more findings

• Biomarkers
• Risk Factors

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Proteomics identifies potential immunological drivers of postinfection brain atrophy and cognitive decline

51/100 ✓ Peer-reviewed Biomarkers Nature aging

Key finding: Infections have been associated with the incidence of Alzheimer disease and related dementias, but the mechanisms responsible for these associations remain unclear. +3 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Blood Pressure, Antihypertensive Use, and Late-Life Alzheimer and Non-Alzheimer Dementia Risk: An Individual Participant Data Meta-Analysis

79/100 ✓ Peer-reviewed Prevention and risk Neurology

Key finding: Antihypertensive use was associated with decreased AD but not non-AD risk throughout late life. +4 more findings

• Risk Factors

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Divergent Mortality Patterns Associated With Dementia in the United States: 1999-2020

75/100 ✓ Peer-reviewed Disparities The primary care companion for CNS disorders

Key finding: Among these, 85.5% were non-Hispanic (NH) white, 8% NH black, 4.34% Hispanic or Latino, 1.6% NH Asian or Pacific Islander, and 0.3% NH American Indian or Alaska Native adults. +4 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source

Cortical neurodegeneration caused by Psen1 mutations is independent of Aβ

43/100 ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America

Key finding: Our findings demonstrate that Psen1 mutations cause age-dependent neurodegeneration independent of Aβ, providing further support for a loss-of-function pathogenic mechanism underlying PSEN mutations.

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

P-tau217 as a Reliable Blood-Based Marker of Alzheimer's Disease

45/100 ✓ Peer-reviewed Biomarkers Biomedicines

Key finding: Phosphorylated tau (p-tau) has shown greater promise in reflecting amyloid pathology as evidenced by CSF and PET positivity. +4 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Educational disparities in brain health and dementia across Latin America and the United States

61/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: The results underscore the impact of education on brain structure and function in LA, highlighting the importance of incorporating educational factors into diagnosing, care, and prevention, and emphasizing the need for global diversity in research. +4 more findings

• Health Equity

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Impaired cellular copper regulation in the presence of ApoE4

43/100 ✓ Peer-reviewed Genetics Journal of neurochemistry

Key finding: Exposure of ApoE target replacement (TR) astrocytes (immortalised astrocytes from APOE knock-in mice) to elevated copper concentrations resulted in exacerbated copper accumulation in ApoE4- compared to ApoE2- and ApoE3-TR astrocytes.

• Genetics
• Policy

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Epidemiology of Homebound Population Among Beneficiaries of a Large National Medicare Advantage Plan

49/100 ✓ Peer-reviewed Health systems and care delivery Annals of Internal Medicine

Key finding: In 2022, the overall prevalence of homebound beneficiaries was 22.0% (8.4% of beneficiaries were homebound, and 13.6% were semihomebound). +4 more findings

• Policy
• Care Services

Full summary, score breakdown and related studies → Original source

Pathogenesis of Cerebral Small Vessel Disease: Role of the Glymphatic System Dysfunction

43/100 ✓ Peer-reviewed Vascular contributions International journal of molecular sciences

Key finding: CSVD may result from dysfunction in the glymphatic system (GS). +1 more finding

• Other Dementias
• Risk Factors

Full summary, score breakdown and related studies → Original source