Newest studies

Physical activity interventions in older adults with a cognitive impairment: A critical review of reviews

70/100 ✓ Peer-reviewed Prevention trials Aging medicine (Milton (N.S.W))

Key finding: Overall, exercise can improve the physical and mental health of people living with dementia: there is sufficient evidence to recommend multimodal exercise.

• Lifestyle

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Plasma Aβ42/Aβ40 Ratios in Older People With Human Immunodeficiency Virus

48/100 ✓ Peer-reviewed Biomarkers Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Key finding: The plasma Aβ42/Aβ40 ratio was significantly lower, and the APS higher, in PWoH_AD than in other groups. +3 more findings

• Biomarkers

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Inequities in Filled Overactive Bladder Medication Prescriptions in the US

54/100 ✓ Peer-reviewed Health systems and care delivery JAMA Network Open

Key finding: An estimated 2 971 449 individuals (mean age, 66.4 years; 95% CI, 64.8-68.2 years) filled prescriptions for OAB medications in 2019; 2 185 214 (73.5%; 95% CI, 62.6%-84.5%) identified as female, 2 326 901 (78.3%; 95% CI, 66.3%-90.3%) self-identified as non-Hispanic White, 260 685 (8.8%; 95% CI, 5.0%-12.5%) identified as non-Hispanic Black, 167 210 (5.6%; 95% CI, 3.1%-8.2%) identified as Hispanic, 158 507 (5.3%; 95% CI, 2.3%-8.4%) identified as non-Hispanic other race, and 58 147 (2.0%; 95% CI, 0.3%-3.6%) identified as non-Hispanic Asian. +4 more findings

• Health Equity
• Treatments

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Association of Chronic Kidney Disease With Plasma NfL and Other Biomarkers of Neurodegeneration: The H70 Birth Cohort Study in Gothenburg

68/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: In a community-based cohort of 70-year olds, P-NfL was associated with both prevalent and incident CKD, while CSF and/or imaging measures did not differ by CKD status. +2 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Translating blood biomarkers into clinical practice for Alzheimer's disease: Challenges and perspectives

45/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Early and accurate diagnosis of Alzheimer's disease (AD) in clinical practice is urgent with advances in AD treatment. +4 more findings

• Biomarkers

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Neuroimaging standards for research into small vessel disease—advances since 2013

64/100 ✓ Peer-reviewed Vascular contributions The Lancet Neurology

• Other Dementias

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Identification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging

62/100 ✓ Peer-reviewed Risk factors Journal of the American Heart Association

Key finding: Portable, low‐field imaging could be useful for identifying moderate to severe WMHs. +3 more findings

• Brain Scans
• Risk Factors
• Care Services

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Global rural health disparities in Alzheimer's disease and related dementias: State of the science

53/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: A location dynamics model and ADRD-focused future directions are offered for guiding rural practitioners, researchers, and policymakers in mitigating rural disparities.

• Health Equity

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FDG PET (and MRI) for Monitoring Immunotherapy in Alzheimer Disease

41/100 ✓ Peer-reviewed Biomarkers Clinical nuclear medicine

Key finding: We question the validity of the evidence for the removal of amyloid in particular as assessed by amyloid PET imaging, believing that what is observed is more likely a large nonspecific amyloid PET signal in the white matter that diminishes during immunotherapy-in line with dose-dependent increases in amyloid-related imaging abnormalities and increased loss of cerebral volume in treated compared with placebo patients.

• Brain Scans
• Treatments

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The affordability of lecanemab, an amyloid-targeting therapy for Alzheimer's disease: an EADC-EC viewpoint

41/100 ✓ Peer-reviewed Treatments The Lancet regional health. Europe

Key finding: This pricing would be unsustainable; the ability to pay for high-priced therapies varies substantially across countries. +4 more findings

• Treatments
• Policy

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Longitudinal changes in Alzheimer's-related plasma biomarkers and brain amyloid

67/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Plasma Aβ42/Aβ40${{\rm A}\beta }_{42}/{{\rm A}\beta }_{40}$ may begin declining decades prior to brain amyloid accumulation, whereas p-tau ratios, GFAP, and NfL increase closer in time.

• Biomarkers

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Alzheimer's disease: Molecular aspects and treatment opportunities using herbal drugs

40/100 ✓ Peer-reviewed Disease mechanisms Ageing research reviews

Key finding: AD is characterized by impaired glutamatergic and cholinergic neurotransmission, which is associated with clinical and pathological symptoms.

• Treatments
• Brain Biology

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Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer's disease patients

41/100 ✓ Peer-reviewed Drug development Journal of translational medicine

Key finding: We identified glutaminase as a promising drug target. +4 more findings

• Treatments
• Brain Biology

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Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS): Study design and harmonization

63/100 ✓ Peer-reviewed Prevention trials Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Currently, 1549 participants have been screened, and 815 randomized. +2 more findings

• Prevention

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APOEε4 and risk of Alzheimer's disease - time to move forward

41/100 ✓ Peer-reviewed TREM2 and immune genetics Frontiers in neuroscience

Key finding: Moreover, the knowledge about the risk associated with APOEε4 has not helped design a meaningful preventative or therapeutic strategy.

• Genetics
• Risk Factors
• Policy

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Neurogenomics of Alzheimer's disease (AD): An Asian population review

41/100 ✓ Peer-reviewed Genetics Clinica chimica acta; international journal of clinical chemistry

Key finding: This indicates that pathogenesis between ethnic groups is distinct.

• Genetics

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Design and feasibility of an Alzheimer's disease blood test study in a diverse community-based population

61/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Of the 859 participants enrolled in this ongoing study, 20.6% self-identified as Black or African American. +4 more findings

• Biomarkers

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Air Pollution: A Silent Key Driver of Dementia

57/100 ✓ Peer-reviewed Risk factors Biomedicines

Key finding: In 2017, the Lancet Commission on Dementia Prevention, Intervention, and Care included air pollution in its list of potential risk factors for dementia; in 2018, the Lancet Commission on Pollution concluded that the evidence for a causal relationship between fine particulate matter (PM) and dementia is encouraging.

• Risk Factors

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Association of gout with brain reserve and vulnerability to neurodegenerative disease

45/100 ✓ Peer-reviewed Risk factors Nature communications

Key finding: These findings suggest gout is causally related to several measures of brain structure.

• Risk Factors

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Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease

73/100 ✓ Peer-reviewed Genetics Molecular psychiatry

Key finding: Our findings highlight the importance of multi-ancestry representation in uncovering and understanding putative factors that contribute to risk of Alzheimer's disease and related dementias.

• Genetics

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Detection and treatment of Alzheimer's disease in its preclinical stage

59/100 ✓ Peer-reviewed Treatments Nature aging

Key finding: Treatment during the preclinical AD phase offers an optimal opportunity for slowing the progression of disease. +4 more findings

• Treatments
• Early Stage

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Longitudinal Relationships of White Matter Hyperintensities and Alzheimer Disease Biomarkers Across the Adult Life Span

53/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: White matter hyperintensities (WMH) correlate with Alzheimer disease (AD) biomarkers cross-sectionally and modulate AD pathogenesis. +3 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Blood biomarkers for Alzheimer's disease in clinical practice and trials

68/100 ✓ Peer-reviewed Getting a diagnosis Nature aging

Key finding: Several assays for measuring phosphorylated tau (p-tau) in plasma exhibit high diagnostic accuracy in distinguishing AD from all other neurodegenerative diseases in patients with cognitive impairment. +4 more findings

• Biomarkers
• Treatments

Full summary, score breakdown and related studies → Original source

Social participation and risk of developing dementia

56/100 ✓ Peer-reviewed Prevention and risk Nature aging

Key finding: Observational study evidence indicates that greater social participation in midlife and late life is associated with 30-50% lower subsequent dementia risk, although some of this may not be causal.

• Risk Factors

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Profiling post-COVID-19 condition across different variants of SARS-CoV-2: a prospective longitudinal study in unvaccinated wild-type, unvaccinated alpha-variant, and vaccinated delta-variant populations

69/100 ✓ Peer-reviewed Cognitive tests and assessment The Lancet. Digital health

Key finding: These three main clusers were confirmed in a testing sample. +4 more findings

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