APOE genotypes modify the obesity paradox in dementia
Mitsuru Shinohara, Ghupurjan Gheni, Junichi Hitomi, Guojun Bu, Naoyuki Sato. Journal of neurology, neurosurgery, and psychiatry, 2023-07-06
Topic: Genetics and APOE
Obesity was associated with cognitive decline in early elderly cognitively normal individuals without APOE4, especially those with APOE2. Neuropathological analyses adjusted for dementia status showed that APOE2 carriers tended to have more microinfarcts and haemorrhages due to obesity. On the other hand, obesity was associated with a lower frequency of dementia and less cognitive impairment in individuals with mild cognitive impairment or dementia. Such trends were particularly strong in APOE4 carriers. Obesity was associated with fewer Alzheimer's pathologies in individuals with dementia. Obesity may accelerate cognitive decline in middle to early elderly cognitive normal individuals without APOE4 likely by provoking vascular impairments. On the other hand, obesity may ease cognitive impairment in both individuals with dementia and individuals at the predementia stage, especially those with APOE4, through protecting against Alzheimer's pathologies. These results support that APOE genotype modifies the obesity paradox in dementia.
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APA 7th
Shinohara, M., Gheni, G., Hitomi, J., Bu, G., & Sato, N. (2023). APOE genotypes modify the obesity paradox in dementia. Journal of neurology, neurosurgery, and psychiatry. https://doi.org/10.1136/jnnp-2022-331034
Vancouver
Shinohara M, Gheni G, Hitomi J, Bu G, Sato N. APOE genotypes modify the obesity paradox in dementia. Journal of neurology, neurosurgery, and psychiatry. 2023. doi:10.1136/jnnp-2022-331034. PMID: 37414536.
BibTeX
@article{shinohara2023-37414536,
author = {Shinohara, Mitsuru and Gheni, Ghupurjan and Hitomi, Junichi and Bu, Guojun and Sato, Naoyuki},
title = {{APOE genotypes modify the obesity paradox in dementia}},
journal = {Journal of neurology, neurosurgery, and psychiatry},
year = {2023},
doi = {10.1136/jnnp-2022-331034},
pmid = {37414536},
url = {https://doi.org/10.1136/jnnp-2022-331034}
}
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Key findings
- Obesity was associated with cognitive decline in early elderly cognitively normal individuals without APOE4, especially those with APOE2.
- Neuropathological analyses adjusted for dementia status showed that APOE2 carriers tended to have more microinfarcts and haemorrhages due to obesity.
- On the other hand, obesity was associated with a lower frequency of dementia and less cognitive impairment in individuals with mild cognitive impairment or dementia.
- Such trends were particularly strong in APOE4 carriers.
- Obesity was associated with fewer Alzheimer's pathologies in individuals with dementia.
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Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 23 of the 56 points we could judge it on, which is 41 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neurology, neurosurgery, and psychiatry) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37414536) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 23 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 23 of the 56 points we could judge it on is 41 out of 100. |
| Total | 41 / 100 | — |
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