Newest studies

Delayed treatment initiation of oral anticoagulants among Medicare patients with atrial fibrillation

31/100 ✓ Peer-reviewed Health systems and care delivery American Heart Journal Plus Cardiology Research and Practice

Key finding: Median age for both cohorts was 78 years. +4 more findings

• Policy

Full summary, score breakdown and related studies → Original source

Reduction in neurons immunoreactive for parvalbumin, calretinin and calbindin in the anteroventral thalamic nuclei of individuals with Down syndrome

16/100 ⚠ Preprint — not yet peer-reviewed Down syndrome and Alzheimer's bioRxiv

Key finding: However, little is known about how the anterior thalamic nuclei are affected in many neurological disorders partly due to difficulties in selective segmentation in in vivo scans, due to their size and location. +3 more findings

• Down Syndrome
• Brain Biology

Scored 19 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Evaluation of ATNPD Framework and Biofluid Markers to Predict Cognitive Decline in Early Parkinson Disease

60/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: In patients with early PD, CSF p-tau 181 and t-tau were low compared with those in controls and did not increase over 5 years of follow-up. +2 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

A national program to advance dementia research in Vietnam

43/100 ✓ Peer-reviewed Caregiving BMC health services research

Key finding: Over four years (2019-2023), we received 62 applications, reviewed 58 applications, and funded 21 projects (4-5 per year). +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Apolipoprotein E Gene in α-Synucleinopathies: A Narrative Review

43/100 ✓ Peer-reviewed Genetics International journal of molecular sciences

Key finding: In this narrative review, we delved into the intricate interplay between Apolipoprotein E (APOE) alleles (typically associated with Alzheimer's disease-AD) and alpha-synucleinopathies (aS-pathies), involving Parkinson's disease (PD), Parkinson's disease dementia (PDD), dementia with Lewy bodies (DLB), and multiple-system atrophy (MSA). +1 more finding

• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

Alzheimer's disease current therapies, novel drug delivery systems and future directions for better disease management

41/100 ✓ Peer-reviewed Costs and economics Journal of controlled release : official journal of the Controlled Release Society

Key finding: Alzheimer's disease (AD), is a neurodegenerative disorder that escalates with time, exerting a significant impact on physical and mental health and leading to death.

• Treatments

Full summary, score breakdown and related studies → Original source

Biomarker Changes during 20 Years Preceding Alzheimer's Disease

69/100 ✓ Peer-reviewed Hippocampus size on brain scans The New England journal of medicine

Key finding: In this study involving Chinese participants during the 20 years preceding clinical diagnosis of sporadic Alzheimer's disease, we observed the time courses of CSF biomarkers, the times before diagnosis at which they diverged from the biomarkers from a matched group of participants who remained cognitively normal, and the temporal order in which the biomarkers became abnormal. +1 more finding

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Features of the Physical and Social Neighborhood Environment and Neighborhood-Level Alzheimer’s Disease and Related Dementia in South Carolina

44/100 ✓ Peer-reviewed Risk factors Environmental Health Perspectives

Key finding: Neighborhood environment features, such as higher air pollution levels, were associated with higher neighborhood ADRD incidence. +1 more finding

• Risk Factors

Full summary, score breakdown and related studies → Original source

When words matter: Building on the DEEP guidance for Dementia-friendly documents

24/100 ✓ Peer-reviewed Health systems and care delivery FPOP Bulletin Psychology of Older People

Key finding: This article builds on prior work by organisations such as the Dementia Engagement and Empowerment Project (DEEP), the Alzheimer’s Society, and AbilityNet. +4 more findings

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Alzheimer's Disease Puzzle: Delving into Pathogenesis Hypotheses

49/100 ✓ Peer-reviewed Inflammation and the immune system Aging and disease

Key finding: It accounts for approximately 60-70% of all dementia cases worldwide. +3 more findings

Full summary, score breakdown and related studies → Original source

Acquired Risk Factors that Influence Risk for Dementia and Possibly Alzheimer Disease

27/100 ✓ Peer-reviewed Drug development South Dakota medicine : the journal of the South Dakota State Medical Association

Key finding: These medications are typically prescribed once AD is diagnosed in the clinical setting in order to slow progression. +2 more findings

• Treatments
• Risk Factors

Full summary, score breakdown and related studies → Original source

Plasma p-tau181 as an outcome and predictor of multidomain intervention effects: a secondary analysis of a randomised, controlled, dementia prevention trial

51/100 ✓ Peer-reviewed Tau biomarkers The lancet. Healthy longevity

Key finding: It is unknown whether multidomain interventions, which might preserve late-life cognition, affect Alzheimer's disease pathology. +3 more findings

• Biomarkers
• Clinical Trials

Full summary, score breakdown and related studies → Original source

An explainable machine learning approach for Alzheimer's disease classification

56/100 ✓ Peer-reviewed Digital health tools Scientific reports

Key finding: The early diagnosis of Alzheimer's disease (AD) presents a significant challenge due to the subtle biomarker changes often overlooked.

• Digital Tools

Full summary, score breakdown and related studies → Original source

Artificial intelligence and open science in discovery of disease-modifying medicines for Alzheimer's disease

50/100 ✓ Peer-reviewed Digital health tools Cell reports. Medicine

Key finding: The high failure rate of clinical trials in Alzheimer's disease (AD) and AD-related dementia (ADRD) is due to a lack of understanding of the pathophysiology of disease, and this deficit may be addressed by applying artificial intelligence (AI) to "big data" to rapidly and effectively expand therapeutic development efforts. +4 more findings

• Digital Tools
• Treatments

Full summary, score breakdown and related studies → Original source

A biological definition of neuronal α-synuclein disease: towards an integrated staging system for research

62/100 ✓ Peer-reviewed Getting a diagnosis The Lancet. Neurology

Key finding: Stage 2 is characterised by subtle signs or symptoms but without functional impairment. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Hearing Loss, Hearing Aid Use, and Risk of Dementia in Older Adults

70/100 ✓ Peer-reviewed Prevention and risk JAMA Otolaryngology-Head & Neck Surgery

Key finding: The results of this cohort study suggest that hearing loss was associated with increased dementia risk, especially among people not using hearing aids, suggesting that hearing aids might prevent or delay the onset and progression of dementia. +4 more findings

• Risk Factors
• Prevention
• Lifestyle

Full summary, score breakdown and related studies → Original source

Risk Factors for Young-Onset Dementia in the UK Biobank

72/100 ✓ Peer-reviewed How common it is JAMA Neurology

Key finding: In this study, several factors, mostly modifiable, were associated with a higher risk of YOD. +3 more findings

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Performance of the Lumipulse plasma Aβ42/40 and pTau181 immunoassays in the detection of amyloid pathology

61/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Lumipulse and IP-MS Aβ42/40 exhibited the highest diagnostic accuracy for detecting an abnormal amyloid-PET (areas under the curve [AUCs] of 0.81 and 0.84, respectively). +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

A multimodal precision-prevention approach combining lifestyle intervention with metformin repurposing to prevent cognitive impairment and disability: the MET-FINGER randomised controlled trial protocol

62/100 ✓ Peer-reviewed Prevention trials Alzheimer's research & therapy

Key finding: MET-FINGER aims to test a FINGER 2.0 multimodal intervention, combining an updated FINGER multidomain lifestyle intervention with metformin, where appropriate, in an APOE ε4-enriched population of older adults (60-79 years) at increased risk of dementia. +1 more finding

• Clinical Trials
• Prevention
• Risk Factors

Full summary, score breakdown and related studies → Original source

Biogen to Realign Resources for Alzheimer's Disease Franchise (Aduhelm discontinuation)

11/100 ⚠ Press release — not a study Treatments Biogen Inc. press release

Key finding: Aduhelm's development and sale is fully discontinued; the FDA-mandated ENVISION confirmatory trial was terminated +2 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Evaluation of serum neurofilament light chain and glial fibrillary acidic protein in the diagnosis of Alzheimer's disease

48/100 ✓ Peer-reviewed Biomarkers Frontiers in neurology

Key finding: Pairwise comparisons among the three groups showed that compared with the health checkup (HC) group, serum NfL and GFAP were increased in both AD and MCI (PNfL < 0.05, PGFAP < 0.01). +4 more findings

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2

51/100 ✓ Peer-reviewed TREM2 and immune genetics The Journal of experimental medicine

Key finding: In these blinding diseases, macrophages accumulate at atrophic sites, but their ontogeny and niche specialization remain poorly understood, especially in humans. +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Tirzepatide prevents neurodegeneration through multiple molecular pathways

45/100 ✓ Peer-reviewed Drug development Journal of translational medicine

Key finding: We demonstrated that TIR can ameliorate high glucose-induced neurodegeneration and overcome neuronal insulin resistance. +3 more findings

• Prevention

Full summary, score breakdown and related studies → Original source

Naturalistic assessment of reaction time variability in older adults at risk for Alzheimer's disease

41/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of the International Neuropsychological Society : JINS

Key finding: Attentional fluctuations over 20-40 seconds assessed in daily life, are sensitive to clinical status and genetic risk for AD. +2 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Biomarkers of Alzheimer's disease and neurodegeneration in dried blood spots-A new collection method for remote settings

60/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Our data suggest that measuring blood biomarkers related to AD pathology and neurodegeneration from DPS venous extends the utility of blood-based biomarkers to remote settings with simplified sampling conditions, storage, and logistics. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source