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Neutrophil counts and cardiovascular disease
Luo J, Thomassen JQ, Nordestgaard BG, Tybjærg-Hansen A, Frikke-Schmidt R.. European heart journal, 2023-12-01
Topic: Risk, prevention and care in population studies
Background and aims Anti-inflammatory trials have shown considerable benefits for cardiovascular disease. High neutrophil counts, an easily accessible inflammation biomarker, are associated with atherosclerosis in experimental studies. This study aimed to investigate the associations between neutrophil counts and risk of nine cardiovascular endpoints using observational and genetic approaches.
Key findings
- High neutrophil counts, an easily accessible inflammation biomarker, are associated with atherosclerosis in experimental studies.
- This study aimed to investigate the associations between neutrophil counts and risk of nine cardiovascular endpoints using observational and genetic approaches.
- Methods Observational studies were conducted in the Copenhagen General Population Study (n = 101 730).
- Genetic studies were firstly performed using one-sample Mendelian randomization (MR) with individual-level data from the UK Biobank (n = 365 913); secondly, two-sample MR analyses were performed using summary-level data from the Blood Cell Consortium (n = 563 085).
Why it matters
This study investigated associations between neutrophil counts and nine cardiovascular endpoints using observational and genetic approaches. It concerns cardiovascular disease, not Alzheimer's disease, and does not address treating, curing or preventing dementia.
Study details
- Participants101
- Evidence strengthLow
How this study scored 55/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (European heart journal) |
| Journal's citation record | 3 / 4 | European Heart Journal: journal h-index 456 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 101 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 166 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 33.2 citations a year over 5 year(s) since 2023 |
| Impact for its field and year | 4 / 6 | Cited 17.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 3 / 4 | Cited 163 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Ruth Frikke‐Schmidt: h-index 65 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Copenhagen: institution h-index 1,378 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37950632) |
| Free to read | 2 / 2 | Free to read |
| Total | 55 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1093/eurheartj/ehad649
- PubMed: 37950632
- Original source →
- Free full text: European Heart Journal →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Luo, J., Thomassen, J. Q., Nordestgaard, B. G., Tybjærg-Hansen, A., & Frikke-Schmidt, R. (2023). Neutrophil counts and cardiovascular disease. European heart journal. https://doi.org/10.1093/eurheartj/ehad649
Vancouver
Luo J, Thomassen JQ, Nordestgaard BG, Tybjærg-Hansen A, Frikke-Schmidt R. Neutrophil counts and cardiovascular disease. European heart journal. 2023. doi:10.1093/eurheartj/ehad649. PMID: 37950632.
BibTeX
@article{luo2023-37950632,
author = {Luo, J. and Thomassen, J. Q. and Nordestgaard, B. G. and Tybjærg-Hansen, A. and Frikke-Schmidt, R.},
title = {{Neutrophil counts and cardiovascular disease}},
journal = {European heart journal},
year = {2023},
doi = {10.1093/eurheartj/ehad649},
pmid = {37950632},
url = {https://doi.org/10.1093/eurheartj/ehad649}
}
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