Newest studies

Fatal iatrogenic cerebral β-amyloid-related arteritis in a woman treated with lecanemab for Alzheimer's disease

79/100 ✓ Peer-reviewed Treatments Nature communications

Key finding: Magnetic resonance imaging revealed she had multifocal swelling and a marked increase in the number of cerebral microhemorrhages. +2 more findings

• Treatments
• Clinical Trials
• Brain Scans

Full summary, score breakdown and related studies → Original source

Gridlock in hospital medicine

43/100 ✓ Peer-reviewed Health systems and care delivery Journal of Hospital Medicine

Key finding: Before the COVID-19 pandemic, supply and demand forcast models predicted significant nursing shortages across the United States through 2030 due to both an aging patient population and nursing workforce.1, 2 However, during the pandemic, we saw an exodus of younger nurses in addition to early retirements. +4 more findings

• Care Services

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Addressing Overlapping Sample Challenges in Genome-Wide Association Studies: Meta-Reductive Approach

41/100 ✓ Peer-reviewed Genetics PloS one

Key finding: In this study, we present a novel methodology, Meta-Reductive Approach (MRA), that was derived algebraically to adjust GWAS results, aiming to neutralize the influence of select cohorts.

• Genetics

Full summary, score breakdown and related studies → Original source

Blood Neurofilament Levels Predict Cognitive Decline across the Alzheimer's Disease Continuum

51/100 ✓ Peer-reviewed Biomarkers International journal of molecular sciences

Key finding: Neurofilament light chain (NfL) is a potential diagnostic and prognostic plasma biomarker for numerous neurological diseases including Alzheimer's disease (AD).

• Biomarkers
• Diagnosis
• Early Stage

Full summary, score breakdown and related studies → Original source

Plasma p-tau212: antemortem diagnostic performance and prediction of autopsy verification of Alzheimer's disease neuropathology

54/100 ✓ Peer-reviewed Biomarkers Nature communications

Key finding: These findings support plasma p-tau212 as a novel peripherally accessible biomarker of AD pathophysiology.

• Biomarkers
• Brain Biology
• Diagnosis

Full summary, score breakdown and related studies → Original source

Disparate Dementia Risk Factors Are Associated with Cognitive Impairment and Rates of Decline in African Americans

50/100 ✓ Peer-reviewed Risk factors Annals of Neurology

Key finding: Hypertension, hypercholesterolemia, obesity, and diabetes were overrepresented in AA participants, but were not associated with cognitive impairment. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

The clinical efficacy of Olibanum gum chewing in patients with Mild-to-Moderate Alzheimer disease: A randomized Parallel-Design controlled trial

57/100 ✓ Peer-reviewed Treatments Neuropsychopharmacology reports

Key finding: This study revealed that 18 weeks of gum chewing with Olibanum did not change the neuropsychological status. +4 more findings

• Clinical Trials

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Pathways linking microbiota-gut-brain axis with neuroinflammatory mechanisms in Alzheimer's pathophysiology

43/100 ✓ Peer-reviewed Disease mechanisms Microbiome research reports

Key finding: Growing evidence suggests the gut microbiome's crucial role in shaping the pathogenesis of AD by influencing inflammatory mediators. +4 more findings

• Brain Biology

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Organ aging signatures in the plasma proteome track health and disease

62/100 ✓ Peer-reviewed Biomarkers Nature

Key finding: We discovered nearly 20% of the population show strongly accelerated age in one organ and 1.7% are multi-organ agers. +4 more findings

• Biomarkers

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Multiphase optimization of a multicomponent intervention for informal dementia caregivers: a study protocol

48/100 ✓ Peer-reviewed Caregiving Trials

Key finding: This is the first study adopting the multiphase optimisation strategy to identify the most active and engaging components of a psychological intervention for caregivers of patients with dementia. +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

A Blood Screening Test for Dementia with Lewy Bodies for Primary Care

48/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease & Parkinsonism

Key finding: The proteomic profile discriminated DLB and PD from NC with an AUC (Area Under the Curve) of 0.96 with demographics of age, sex and education. +3 more findings

• Other Dementias
• Diagnosis
• Care Services

Full summary, score breakdown and related studies → Original source

Blood-based biomarkers in Alzheimer's disease: Future directions for implementation

45/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Current diagnostic pathways are heterogeneous, meaning many AD patients are missed while low-risk patients undergo unnecessary procedures. +4 more findings

• Biomarkers

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Donanemab in Early Symptomatic Alzheimer’s Disease: Efficacy and Safety in TRAILBLAZER‐ALZ 2, a Phase 3 Randomized Clinical Trial

64/100 ✓ Peer-reviewed Treatments Alzheimer s & Dementia

Key finding: Donanemab treatment significantly slowed clinical progression at 76w and had a safety profile consistent with earlier studies. +4 more findings

• Treatments
• Clinical Trials
• Side Effects

Full summary, score breakdown and related studies → Original source

Dementia caregiver burdens predict overnight hospitalization and hospice utilization

63/100 ✓ Peer-reviewed End-of-life care Palliative & supportive care

Key finding: Alive PWD (n = 804) were 2.36 times more likely to have an overnight hospital stay (p = 0.004) and 1.96 times more likely to have multiple hospitalizations when caregivers found it physically difficult to provide care (p = 0.011). +4 more findings

• End-of-Life Care
• Care Services
• Caregiving

Full summary, score breakdown and related studies → Original source

The Association Between Exposure to Air Pollution and Dementia Incidence: The Modifying Effect of Smoking

50/100 ✓ Peer-reviewed Risk factors The journals of gerontology. Series A, Biological sciences and medical sciences

Key finding: During a median 11.7 years follow-up, 5 905 incident cases of all-cause dementia were identified. +4 more findings

• Risk Factors

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[18F]PI-2620 Binding Patterns in Patients with Suspected Alzheimer Disease and Frontotemporal Lobar Degeneration

48/100 ✓ Peer-reviewed Brain scans and imaging Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Key finding: Patients with suspected AD neuropathology (Aβ-positive patients with mild cognitive impairment or AD dementia) showed high-intensity temporoparietal cortex-predominant [18F]PI-2620 binding. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Microbiota from Alzheimer's patients induce deficits in cognition and hippocampal neurogenesis

47/100 ✓ Peer-reviewed Disease mechanisms Brain : a journal of neurology

Key finding: We found impairments in behaviours reliant on adult hippocampal neurogenesis, an essential process for certain memory functions and mood, resulting from Alzheimer's patient transplants. +2 more findings

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Cluster‐Derived Psychosocial Phenotypes, Cognitive Outcomes, and AD Plasma Biomarkers of Black and Hispanic/Latino Older Adults Enrolled in HABS‐HD

47/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: The cluster analysis identified 3 distinct groups: Group 1 was low resource/high distress (n = 215); Group 2 was high resource/low distress (n = 248); and Group 3 was low resource/low distress (n = 353; Figure 1). +4 more findings

• Health Equity
• Biomarkers

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CHARACTERISTICS AND CARE EXPERIENCES OF OLDER DUAL-ENROLLEES LIVING IN AREAS WITH MEDICAID MANAGED LTSS

36/100 ✓ Peer-reviewed Risk factors Innovation in Aging

Key finding: Medicaid-funded long-term services and supports (LTSS) are foundational in helping older dual-enrollees with disabilities remain in the community. +1 more finding

• Policy

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Effects of structural and social determinants of health and comorbidities on ethno‐racial differences in ATN plasma biomarkers of Alzheimer’s disease: A HABS‐HD study

43/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Using a large and diverse community‐based cohort, we demonstrate that ethno‐racial differences in AD‐specific plasma biomarkers are, in part, due to modifiable health and comorbidity factors. +1 more finding

• Biomarkers
• Health Equity
• Risk Factors

Full summary, score breakdown and related studies → Original source

“Taxes, death, and trouble”: Role of structural socioeconomic racism on cognitive function for persons racialized as Black

43/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Participants racialized as Black who lived in places with higher levels of area‐level structural socioeconomic racism experienced lower levels of cognition at baseline and at varying time points in the six‐year period—compared to those in places with lower structural socioeconomic racism. +1 more finding

• Health Equity

Full summary, score breakdown and related studies → Original source

Disparities in Research Participation within a Multi‐Racial SARS‐CoV‐2 Cohort for Evaluation of Ultrahigh Field (7T) MRI and Clinical Precursors of Alzheimer’s Disease and Related Dementias

44/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: It is imperative to recognize and mitigate persistent disparities in the COVID‐19 pandemic, particularly pertaining to participation in long‐COVID research. +4 more findings

• Health Equity
• Brain Scans

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Interaction between DNA methylation and neighborhood disadvantage may impact risk for cognitive decline among Mexican Americans enrolled in the Health and Aging Brain Study – Health Disparities (HABS‐HD) Cohort

39/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: The lack of significant results for moderation effects of the targeted epigenetic markers in our pilot study were likely due to the small sample size. +4 more findings

• Health Equity
• Biomarkers

Full summary, score breakdown and related studies → Original source

“The place where danger waits”: Ten years of the 1994 Crime Bill incarceration on cognitive function in older adults racialized as Black

44/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Ten‐year Black‐White disparities in prison population are associated with cognitive decline among people racialized as Black starting one year later. +4 more findings

Full summary, score breakdown and related studies → Original source

Navigational Decision‐Making Among Older Drivers: An Analysis of Real‐World Driving Patterns

44/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: This study reveals significant differences in driving patterns between cognitively normal older adults and those with cognitive impairment. +4 more findings

Full summary, score breakdown and related studies → Original source