Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 13,351–13,375 of 27,380 studies, newest first · page 535 of 1096.
January 2019 21
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2019-01-01
Resting State Abnormalities of the Default Mode Network in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis
62/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Alzheimer's disease : JAD
Key finding: Qualitatively, our review of 57 MCI versus HC comparisons suggests substantial inconsistency; 9 showed no group difference, 8 showed MCI > HC and 22 showed HC > MCI across the brain, and 18 showed regionally-mixed directions of effect. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-01-01
Plasma Aβ42/40 Ratio Detects Early Stages of Alzheimer's Disease and Correlates with CSF and Neuroimaging Biomarkers in the AB255 Study
49/100 ✓ Peer-reviewed Mild cognitive impairment The journal of prevention of Alzheimer's disease
Key finding: TP42/40 demonstrated value in the identification of individuals suffering a-MCI, in the prediction of progression to dementia, and in the detection of underlying AD pathology revealed by FDG-PET, Amyloid-PET and CSF biomarkers, being, thus, consistently associated with all the well-established indicators of AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-01-01
Microbleeds and Cerebral Amyloid Angiopathy in the Brains of People with Down Syndrome with Alzheimer's Disease
41/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of Alzheimer's disease : JAD
Key finding: Cerebrovascular pathology is a significant mediator in Alzheimer's disease (AD) in the general population. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-01-01
Detecting Apathy in Older Adults with Cognitive Disorders Using Automatic Speech Analysis
48/100 ✓ Peer-reviewed Digital health tools Journal of Alzheimer's disease : JAD
Key finding: These findings reinforce the usability of speech as a reliable biomarker in the detection and assessment of apathy. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-01-01
Maintain Your Brain: Protocol of a 3-Year Randomized Controlled Trial of a Personalized Multi-Modal Digital Health Intervention to Prevent Cognitive Decline Among Community Dwelling 55 to 77 Year Olds
65/100 ✓ Peer-reviewed Digital health tools Journal of Alzheimer's disease : JAD
Key finding: MYB will be the largest internet-based trial to attempt to prevent cognitive decline and potentially dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-01-01
Mobile Technology for Cognitive Assessment of Older Adults: A Scoping Review
45/100 ✓ Peer-reviewed Digital health tools Innovation in aging
Key finding: Twenty-nine articles met our inclusion criteria and were categorized into 3 groups as follows: (a) mobile versions of existing article or computerized neuropsychological tests; (b) new cognitive tests developed specifically for mobile platforms; and (c) the use of new types of data for cognitive assessment. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-01-01
Early-Life Risk Factors for Dementia and Cognitive Impairment in Later Life: A Systematic Review and Meta-Analysis
69/100 ✓ Peer-reviewed Disparities Journal of Alzheimer's disease : JAD
Key finding: Early-life factors, including education level, leg length, history of childhood head trauma, family-related factors and learning ability, were associated with the risk of dementia and cognitive impairment in later life. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-01-01
Effect of a Lay Counselor Intervention on Prevention of Major Depression in Older Adults Living in Low- and Middle-Income Countries: A Randomized Clinical Trial
72/100 ✓ Peer-reviewed Disparities JAMA psychiatry
Key finding: The study enrolled 181 participants (mean [SD] age, 69.6 [7.2] years; 114 [63.0%] female): 91 to the intervention arm (depression in later life [DIL] intervention) and 90 to care as usual (CAU).
Full summary, score breakdown and related studies → Original source
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2019-01-01
Ordered Assembly of Tau Protein and Neurodegeneration
44/100 ✓ Peer-reviewed Disparities Advances in experimental medicine and biology
Key finding: It has been suggested that different conformers of assembled tau may give rise to different human tauopathies, but until recently, it was not possible to study this directly. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-01-01
Neuropathological Diagnoses of Demented Hispanic, Black, and Non-Hispanic White Decedents Seen at an Alzheimer's Disease Center
51/100 ✓ Peer-reviewed Disparities Journal of Alzheimer's disease : JAD
Key finding: Alzheimer's disease (AD) without significant cerebrovascular disease (CVD) or other dementia-related pathologies (AD (non-mixed)) was present in 15 Black (43%), 4 Hispanic (14%), and 156 (43%) non-Hispanic Whites. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-01-01
Air Pollution, Stress, and Allostatic Load: Linking Systemic and Central Nervous System Impacts
45/100 ✓ Peer-reviewed Caregiving Journal of Alzheimer's disease : JAD
Key finding: Recent experimental evidence has shown that particulate matter and ozone, two common pollutants with differing characteristics and reactivity, can activate the hypothalamic-pituitary-adrenal (HPA) axis and release glucocorticoid stress hormones (cortisol in humans, corticosterone in rodents) as part of a neuroendocrine stress response.
Full summary, score breakdown and related studies → Original source
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2019-01-01
Alzheimer's disease
51/100 ✓ Peer-reviewed Caregiving Handbook of clinical neurology
Key finding: Alzheimer's disease (AD) dementia refers to a particular onset and course of cognitive and functional decline associated with age together with a particular neuropathology.
Full summary, score breakdown and related studies → Original source
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2019-01-01
Association of Bilateral Salpingo-Oophorectomy Before Menopause Onset With Medial Temporal Lobe Neurodegeneration
59/100 ✓ Peer-reviewed Brain scans and imaging JAMA neurology
Key finding: Forty-one women who underwent BSO and 49 control participants were recruited. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-01-01
Glial Fibrillary Acidic Protein in Serum is Increased in Alzheimer's Disease and Correlates with Cognitive Impairment
55/100 ✓ Peer-reviewed Getting a diagnosis Journal of Alzheimer's disease : JAD
Key finding: Sensitivity and specificity of serum GFAP for AD versus bvFTD was 89% and 79% and might be the first blood biomarker in the differential diagnosis of AD and bvFTD.
Full summary, score breakdown and related studies → Original source
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2019-01-01
Olfactory and other sensory impairments in Alzheimer disease
50/100 ✓ Peer-reviewed Getting a diagnosis Nature reviews. Neurology
Key finding: Current evidence regarding the potential markers of AD in each modality is examined, with a particular emphasis on olfaction and current findings that olfactory function is associated with prodromal AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-01-01
Modifiable Risk Factors Explain Socioeconomic Inequalities in Dementia Risk: Evidence from a Population-Based Prospective Cohort Study
70/100 ✓ Peer-reviewed Prevention and risk Journal of Alzheimer's disease : JAD
Key finding: Socioeconomic differences in dementia risk can be partly explained by differences in modifiable health conditions and lifestyle factors. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-01-01
Dietary Patterns and Cognitive Health in Older Adults: A Systematic Review
60/100 ✓ Peer-reviewed Prevention and risk Journal of Alzheimer's disease : JAD
Key finding: Evidence from other dietary patterns such as the MIND, DASH, Anti-inflammatory, and Prudent healthy diets was more limited but showed promising results, especially for those at risk of cardiovascular disease. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-01-01
Clinical Significance of Magnetic Resonance Imaging Markers of Vascular Brain Injury: A Systematic Review and Meta-analysis
79/100 ✓ Peer-reviewed Prevention and risk JAMA neurology
Key finding: Of 2846 articles identified, 94 studies were eligible, with up to 14 529 participants for WMH, 16 012 participants for BI, 15 693 participants for CMB, and 4587 participants for PVS. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-01-01
Safety, Tolerability, and Feasibility of Young Plasma Infusion in the Plasma for Alzheimer Symptom Amelioration Study: A Randomized Clinical Trial
72/100 ✓ Peer-reviewed Treatments JAMA neurology
Key finding: There was no difference in the age (mean [SD], 74.17 [7.96] years), sex (12 women [67%]), or baseline Mini-Mental State Examination score (mean [SD], 19.39 [3.24]) between the crossover (n = 9) and open-label groups (n = 9). +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-01-01
Physical Activity as a Moderator of Alzheimer Pathology: A Systematic Review of Observational Studies
59/100 ✓ Peer-reviewed Biomarkers Current Alzheimer research
Key finding: The quality of included studies with only a few longitudinal studies, limits the conclusions which may be drawn from the present findings especially regarding the biomarkers other than hippocampal volume. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019 year only
Genetic risk for Alzheimer disease is distinct from genetic risk for amyloid deposition
61/100 ✓ Peer-reviewed Genetics Annals of Neurology
Key finding: 770 ADNI participants analyzed (174 AD, 344 MCI, 224 controls); 663 had amyloid PET data +4 more findings
Full summary, score breakdown and related studies → Original source
December 2018 4
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2018-12-30
Do Caregiver Characteristics Affect Caregiver Burden Differently in Different Countries?
46/100 ✓ Peer-reviewed Caregiving American journal of Alzheimer's disease and other dementias
Key finding: When the caregiver is a spouse or long-term partner of the person with dementia, lives in the same house as this person, or spends fewer than 20 h/wk for other duties than care, this is associated with less caregiver burden in England but with more caregiver burden in Greece.
Full summary, score breakdown and related studies → Original source
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2018-12-30
Planning ahead with dementia: what role can advance care planning play? A review on opportunities and challenges
38/100 ✓ Peer-reviewed End-of-life care Swiss medical weekly
Key finding: However, even though neurodegenerative dementia results in the gradual loss of decision-making capacity, ACP is still extremely rare. +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-12-28
Apolipoprotein E in lipoprotein metabolism, health and cardiovascular disease
38/100 ✓ Peer-reviewed Prevention and risk Pathology
Key finding: Paradoxically, under metabolic stress, homozygosity for apoE2 may result in dysbetalipoproteinaemia in adults owing to impaired binding of remnant lipoproteins to the LDL receptor and related proteins as well as heparan sulphate proteoglycans.
Full summary, score breakdown and related studies → Original source
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2018-12-28
Amyloid-beta and phosphorylated tau in post-mortem Alzheimer's disease retinas
48/100 ✓ Peer-reviewed Brain scans and imaging Acta neuropathologica communications
Key finding: A diffuse immunoreactive signal for pTau was increased in the inner and outer plexiform layers of the retina in AD cases compared to control cases with absence of cerebral amyloid pathology. +2 more findings
Full summary, score breakdown and related studies → Original source
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