Newest studies

Polygenic risk for Alzheimer's disease is associated with neuroaxonal damage before onset of clinical symptoms

63/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Nineteen participants developed AD after a median of 60 months (interquartile range 30). +4 more findings

• Genetics

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Head-to-head study of diagnostic accuracy of plasma and cerebrospinal fluid p-tau217 versus p-tau181 and p-tau231 in a memory clinic cohort

57/100 ✓ Peer-reviewed Biomarkers Journal of neurology

Key finding: Plasma p-tau217 demonstrated better performance in the identification of AD pathology and clinical phenotypes in comparison with other variants of p-tau in a memory clinic cohort. +4 more findings

• Biomarkers
• Diagnosis
• Care Services

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Comparative Study of Risk Factors Associated with Normal Cognition and Cognitive Impairment in Rural West Elderly Texans

34/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer s Disease Reports

Key finding: Summary statistics were obtained for sociodemographic and chronic diseases by using cross-tabulation analysis and comparing the county respondents with proportion tests. +4 more findings

• Risk Factors
• Health Equity

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Social Determinants of Health, Risk and Resilience against Alzheimer’s Disease and Related Dementias: The Healthy Brain Initiative

53/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer s Disease Reports

Key finding: Perceived greater access to greenspaces (estimate = 2.83, 95% CI = 1.40–4.26) and greater time in neighborhood greenspaces were associated with greater RI scores (estimate = 2.30, 95% CI = 1.24–3.35). +4 more findings

• Health Equity

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Characterizing Neighborhood Vulnerabilities in Mild Cognitive Impairment using the Environmental Justice Index

41/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer s Disease Reports

Key finding: Environmental Burden Rank (EBR) across the sample (0.53±0.32) was near the 50th percentile nationally. +4 more findings

• Early Stage

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The growing link between microbes, mood and mental health

30/100 ✓ Peer-reviewed Risk factors Knowable Magazine

Key finding: Most remarkably, research by Cryan and others has shown that transplanting microbes from the guts of people with psychiatric disorders like depression to the guts of rodents can cause comparable symptoms in the animals.CREDIT: JAMES PROVOST (CC BY-ND)Neuroscientist John CryanUniversity College CorkThese effects may occur in several ways — through the vagus nerve connecting the gut to the brain, through the influence of gut bacteria on our immune systems, or by microbes synthesizing molecules that our nerve cells use to communicate. +4 more findings

• Brain Biology

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The Importance of Complement-Mediated Immune Signaling in Alzheimer's Disease Pathogenesis

51/100 ✓ Peer-reviewed TREM2 and immune genetics International journal of molecular sciences

Key finding: The complement cascade has complex roles in the central nervous system (CNS), most of what we know about it stems from its role in brain development. +3 more findings

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Cerebrospinal fluid proteomics in patients with Alzheimer's disease reveals five molecular subtypes with distinct genetic risk profiles

64/100 ✓ Peer-reviewed TREM2 and immune genetics Nature aging

Key finding: Understanding this heterogeneity is critical for AD drug development. +3 more findings

• Genetics
• Biomarkers

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Harnessing digital health interventions to bridge the gap in prevention for older adults

45/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in Public Health

Key finding: The health issues associated with aging not only have a significant impact on the overall well-being of older individuals but also puts a lot of pressure of the healthcare system (3). +4 more findings

• Digital Tools
• Prevention
• Health Equity

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Cell type-specific roles of APOE4 in Alzheimer disease

52/100 ✓ Peer-reviewed Genetics Nature reviews. Neuroscience

Key finding: In particular, cutting-edge omics studies have enabled APOE4 to be studied at the single-cell level and have allowed the identification of critical APOE4 effects in AD-vulnerable cellular subtypes. +4 more findings

• Genetics
• Brain Biology

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Caregiver Experiences with Dementia-Related Feeding/Eating Difficulties

50/100 ✓ Peer-reviewed Caregiving Healthcare (Basel, Switzerland)

Key finding: The results show that nearly all persons living with dementia had symptoms of feeding/eating problems, requiring caregiver support, ranging from verbal assistance to full physical assistance.

• Caregiving

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Genome-wide association studies identify novel loci in rapidly progressive Alzheimer's disease

50/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: We identified 115 pathology-confirmed rpAD cases and 193 clinical rpAD cases, 80% and 69% were of non-Hispanic European ancestry. +4 more findings

• Genetics

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Racial disparities in subjective cognitive decline and its implications among Alzheimer's caretakers

43/100 ✓ Peer-reviewed Disparities Journal of the National Medical Association

Key finding: Significant disparities in symptom severity reported by Alzheimer's caretakers were observed among the racial groups analyzed. +4 more findings

• Health Equity

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Sleep and circadian rhythm disruptions in behavioral variant frontotemporal dementia

46/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Compared to controls, bvFTD patients showed longer time in bed (95% confidence interval [CI]: 79.31, 321.83) and total sleep time (95% CI: 24.38, 321.88), lower sleep efficiency (95% CI: -12.58, -95.54), and rest-activity rhythm alterations in the morning and early afternoon. +4 more findings

• Other Dementias
• Lifestyle

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GLP-1 derivatives with functional sequences transit and migrate through trigeminal neurons

43/100 ✓ Peer-reviewed Drug development European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Key finding: Moreover, PAS-CPP-GLP-1 showed significant improvement in learning memory in mice within 20 min of intranasal administration. +1 more finding

• Brain Biology

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Ocular biomarkers of cognitive decline based on deep-learning retinal vessel segmentation

55/100 ✓ Peer-reviewed Brain scans and imaging BMC geriatrics

Key finding: The fractal dimension (FD) and global vein width were significantly correlated with the CI (P < 0.05). +2 more findings

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Alzheimer's Disease: The Past, Present, and Future of a Globally Progressive Disease

43/100 ✓ Peer-reviewed Drug development Cureus

Key finding: Alzheimer's disease (AD) is a significant 21st-century public health challenge.

• Treatments
• Brain Biology

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Imaging spectrum of amyloid-related imaging abnormalities associated with aducanumab immunotherapy

41/100 ✓ Peer-reviewed Treatments Frontiers in radiology

Key finding: Aducanumab has shown promising clinical and biomarker efficacy but is associated with amyloid-related imaging abnormalities (ARIA).

• Treatments
• Side Effects
• Brain Scans

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SCAN: Spatiotemporal Cloud Atlas for Neural cells

43/100 ✓ Peer-reviewed Genetics Nucleic acids research

Key finding: Furthermore, over 100 neurological diseases (e.g. +4 more findings

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TREM2 macrophage promotes cardiac repair in myocardial infarction by reprogramming metabolism via SLC25A53

51/100 ✓ Peer-reviewed TREM2 and immune genetics Cell death and differentiation

Key finding: TREM2 has been proven to participate in phagocytosis and metabolism, but how it modulates myocardial infarction remains unclear. +3 more findings

• Genetics

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Gut microbiota, circulating cytokines and dementia: a Mendelian randomization study

43/100 ✓ Peer-reviewed Genetics Journal of neuroinflammation

Key finding: There were 20 positive and 16 negative causal effects between genetic liability in the gut microbiota and dementia. +3 more findings

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Current understanding of the Alzheimer's disease-associated microbiome and therapeutic strategies

45/100 ✓ Peer-reviewed Disease mechanisms Experimental & molecular medicine

Key finding: In recent years, the microbiota-gut-brain axis has received significant attention in the AD field. +1 more finding

• Treatments

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Traffic-related air pollution and dementia incidence in the Adult Changes in Thought Study

70/100 ✓ Peer-reviewed Risk factors Environment international

Key finding: We identified 1,041 incident all-cause dementia cases in 4,283 participants over 37,102 person-years of follow-up. +4 more findings

• Risk Factors

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Pharmacological Approaches Using Diabetic Drugs Repurposed for Alzheimer's Disease

43/100 ✓ Peer-reviewed Drug development Biomedicines

Key finding: Insulin resistance in the periphery is significant in the development of T2DM and it has been posited that insulin resistance in the brain plays a key role in AD pathogenesis, earning AD the name "type 3 diabetes". +1 more finding

• Treatments
• Risk Factors

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Immune and inflammatory mechanisms in hypertension

41/100 ✓ Peer-reviewed Risk factors Nature reviews. Cardiology

Key finding: IL-17 secreted by CD4 + T helper 17 cells and γδ T cells, and interferon-γ and tumour necrosis factor secreted by immunosenescent CD8 + T cells, exert crucial effector roles in hypertension, whereas IL-10 and regulatory T cells are protective. +4 more findings

• Risk Factors
• Brain Biology

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