Gut microbiota, circulating cytokines and dementia: a Mendelian randomization study
Dong Ji, Wen-Zhu Chen, Lei Zhang, Zhi-Hua Zhang, Li-Jian Chen. Journal of neuroinflammation, 2024-01-04
Topic: Gut, metabolism and diet
There were 20 positive and 16 negative causal effects between genetic liability in the gut microbiota and dementia. Also, there were five positive and four negative causal effects between cytokines and dementias. Cytokines did not act as mediating factors. Gut microbiota and cytokines were causally associated with five types of dementia, and cytokines seemed not to be the mediating factors in the pathway from gut microbiota to dementia.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Ji, D., Chen, W.-Z., Zhang, L., Zhang, Z.-H., & Chen, L.-J. (2024). Gut microbiota, circulating cytokines and dementia: a Mendelian randomization study. Journal of neuroinflammation. https://doi.org/10.1186/s12974-023-02999-0
Vancouver
Ji D, Chen W.-Z, Zhang L, Zhang Z.-H, Chen L.-J. Gut microbiota, circulating cytokines and dementia: a Mendelian randomization study. Journal of neuroinflammation. 2024. doi:10.1186/s12974-023-02999-0. PMID: 38178103.
BibTeX
@article{ji2024-38178103,
author = {Ji, Dong and Chen, Wen-Zhu and Zhang, Lei and Zhang, Zhi-Hua and Chen, Li-Jian},
title = {{Gut microbiota, circulating cytokines and dementia: a Mendelian randomization study}},
journal = {Journal of neuroinflammation},
year = {2024},
doi = {10.1186/s12974-023-02999-0},
pmid = {38178103},
url = {https://doi.org/10.1186/s12974-023-02999-0}
}
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Key findings
- There were 20 positive and 16 negative causal effects between genetic liability in the gut microbiota and dementia.
- Also, there were five positive and four negative causal effects between cytokines and dementias.
- Cytokines did not act as mediating factors.
- Gut microbiota and cytokines were causally associated with five types of dementia, and cytokines seemed not to be the mediating factors in the pathway from gut microbiota to dementia.
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Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 24 of the 56 points we could judge it on, which is 43 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neuroinflammation) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38178103) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 24 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 24 of the 56 points we could judge it on is 43 out of 100. |
| Total | 43 / 100 | — |
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