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41/100

✓ Peer-reviewed alzhub usefulness score 41 out of 100. Risk factors

Topic: Risk, prevention and care in population studies

Environmental Burden Rank (EBR) across the sample (0.53±0.32) was near the 50th percentile nationally. When divided by race/ethnicity, environmental ( p = 0.025) and social ( p < 0.0001) vulnerabilities were significantly elevated for minorities, specifically for exposure to ozone, diesel particulate matter, carcinogenic air toxins, and proximity to treatment storage and disposal sites. ADI state decile was not correlated with the EBR. Neither EBR nor ADI were a significant predictor of cognitive decline. To our knowledge, this is the first study to link the EJI to an MCI trial. Despite limitations of a relatively small sample size, the study illustrates the potential of the EJI to provide deeper phenotyping of the exposome and diversity in clinical trial subjects.

Key findings

Environmental Burden Rank (EBR) across the sample (0.53±0.32) was near the 50th percentile nationally.
When divided by race/ethnicity, environmental ( p = 0.025) and social ( p < 0.0001) vulnerabilities were significantly elevated for minorities, specifically for exposure to ozone, diesel particulate matter, carcinogenic air toxins, and proximity to treatment storage and disposal sites.
ADI state decile was not correlated with the EBR.
Neither EBR nor ADI were a significant predictor of cognitive decline.
To our knowledge, this is the first study to link the EJI to an MCI trial.

Why it matters

This study found that environmental and social vulnerabilities were elevated for minorities in a mild cognitive impairment trial, but neither environmental burden nor neighborhood deprivation predicted cognitive decline. It is a small study and does not provide evidence for treating, curing, or preventing Alzheimer's disease.

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Study details

Evidence strengthLow

How this study scored 41/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of Alzheimer s Disease Reports)
Journal's citation record	0 / 4	Journal of Alzheimer s Disease Reports: journal h-index 40 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2024 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 9 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	2.2 citations a year over 4 year(s) since 2024
Impact for its field and year	3 / 6	Cited 6.7× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 9 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Pudugramam Murali Doraiswamy: h-index 105 (OpenAlex, whole career)
Institution's track record	2 / 3	Columbia University: institution h-index 1,824 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 4 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 38910939)
Free to read	2 / 2	Free to read
Total	41 / 100	—

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Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.

APA 7th

Adhikari, A., Nwosu, A., Qian, M., Hellegers, C., Devanand, D. P., & Doraiswamy, P. M. (2024). Characterizing Neighborhood Vulnerabilities in Mild Cognitive Impairment using the Environmental Justice Index. Journal of Alzheimer s Disease Reports. https://doi.org/10.3233/adr-240020

Vancouver

Adhikari A, Nwosu A, Qian M, Hellegers C, Devanand DP, Doraiswamy PM. Characterizing Neighborhood Vulnerabilities in Mild Cognitive Impairment using the Environmental Justice Index. Journal of Alzheimer s Disease Reports. 2024. doi:10.3233/adr-240020. PMID: 38910939.

BibTeX

@article{adhikari2024-38910939,
  author  = {Adhikari, Alisa and Nwosu, Adaora and Qian, Min and Hellegers, Caroline and Devanand, Davangere P. and Doraiswamy, Pudugramam Murali},
  title   = {{Characterizing Neighborhood Vulnerabilities in Mild Cognitive Impairment using the Environmental Justice Index}},
  journal = {Journal of Alzheimer s Disease Reports},
  year    = {2024},
  doi     = {10.3233/adr-240020},
  pmid    = {38910939},
  url     = {https://doi.org/10.3233/adr-240020}
}

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