Newest studies

Uncovering stage‐specific neural and molecular progression in Alzheimer's disease: Implications for early screening

48/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s & Dementia

Key finding: Key markers and mechanisms were identified for each stage: initial neurophysiological deficits in SCD with compensatory metabolomic responses, gut-brain axis dysregulation in MCI, and extensive metabolic disruption and multisystem breakdown in AD. +4 more findings

• Early Stage
• Diagnosis

Full summary, score breakdown and related studies → Original source

The impact of cholinesterase inhibitors on cognitive trajectories in mild cognitive impairment patients based on amyloid beta status

49/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s & Dementia

Key finding: Among 558 amnestic MCI participants (168 ChEI users), ChEI users exhibited higher risk of progression to AD dementia (hazard ratio = 1.77, 95% confidence interval: 1.15 to 2.73, p = 0.001). +4 more findings

• Early Stage
• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Neural network disruptions between default mode network and salience network in mild cognitive impairment with neuropsychiatric symptoms

49/100 ✓ Peer-reviewed Mild cognitive impairment International Psychogeriatrics

Key finding: In the MCI+NPS group, the most frequently endorsed NPS was anxiety (46.2 %), the less prevalent NPS was euphoria/elation (1.44 %). +4 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Sex differences in prodromal dementia with Lewy bodies using the National Alzheimer's Coordinating Center data

49/100 ✓ Peer-reviewed Lewy body dementia Alzheimer s & Dementia

Key finding: Males were more likely than females to present with two or more core DLB clinical features 2 years prior to obtaining a diagnosis of dementia. +4 more findings

• Other Dementias
• Early Stage

Full summary, score breakdown and related studies → Original source

NLRP3 Inflammasome in Vascular Dementia: Regulatory Mechanisms, Functions, and Therapeutic Implications: A Comprehensive Review

38/100 ✓ Peer-reviewed Lewy body dementia CNS Neuroscience & Therapeutics

Key finding: The NLRP3 inflammasome pathway destroys neuronal cells primarily through the production of IL-18 and IL-1β. +4 more findings

• Other Dementias
• Treatments

Full summary, score breakdown and related studies → Original source

Profile of impairments in social and non-social cognition in vascular dementia compared to Alzheimer’s disease and behavioral variant frontotemporal dementia

37/100 ✓ Peer-reviewed Lewy body dementia Journal of the International Neuropsychological Society

Key finding: All patient groups were also impaired on AVLT encoding, TMT-B and TMT B/A. +3 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Neuroimaging and plasma biomarker differences and commonalities in Lewy body dementia subtypes

47/100 ✓ Peer-reviewed Lewy body dementia Alzheimer s & Dementia

Key finding: We show reduced fiber cross-section in LBD versus PD, and increased concentrations of plasma neurofilament light chain and p-tau217; with p-tau217 and fiber cross-section associated with cognition. +4 more findings

• Other Dementias
• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

The Association of Apathy With Incident Dementia: A Multiple Mediation Analysis of Cardiovascular Risk Factors

45/100 ✓ Peer-reviewed Risk factors International Journal of Geriatric Psychiatry

Key finding: Of the association between apathy and dementia (HR 1.49 [95% CI 0.99-2.41]), 27% was mediated by physical inactivity, BMI and diabetes combined. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Alzheimer's Disease and Frontotemporal Dementia: A Review of Pathophysiology and Therapeutic Approaches

42/100 ✓ Peer-reviewed Risk factors Journal of Neuroscience Research

Key finding: Frontotemporal dementia (FTD) is another type of dementia characterized by a spectrum of behaviors, memory, and motor abnormalities and associated with abnormal depositions of protein aggregation, including tau protein.

• Treatments
• Risk Factors
• Other Dementias

Full summary, score breakdown and related studies → Original source

Sex and socioeconomic differences in 15-year prevalence trends for modifiable dementia risk factors in Australia: a cross-sectional, time series analysis

47/100 ✓ Peer-reviewed Risk factors The Lancet Healthy Longevity

Key finding: In mid-life, the sample sizes ranged from 4100 in 2022 to 5589 in 2017-18 and in late-life from 2799 in 2011-12 to 3762 in 2017-18. +4 more findings

• Risk Factors
• Health Equity
• Prevention

Full summary, score breakdown and related studies → Original source

Emerging trends in Alzheimer's disease diagnosis and prediction using artificial intelligence: A bibliometric analysis of the top cited 100 articles

34/100 ✓ Peer-reviewed Digital health tools Digital Health

Key finding: It was found that the top cited 100 articles came from 51 journals and 31 countries. +4 more findings

• Digital Tools
• Diagnosis

Full summary, score breakdown and related studies → Original source

Comprehensive Machine Learning-Based Prediction Model for Delirium Risk in Older Patients with Dementia: Risk Factors Identification

43/100 ✓ Peer-reviewed Digital health tools Clinical Interventions in Aging

Key finding: The final analysis included 636 older dementia patients, with a mean age of 78.2 ± 6.3 years, of whom 187 (29.4%) developed delirium during hospitalization. +4 more findings

• Risk Factors
• Digital Tools

Full summary, score breakdown and related studies → Original source

The role of per‐ and polyfluoroalkyl substances in cognitive impairment and dementia

50/100 ✓ Peer-reviewed How common it is Alzheimer s & Dementia

Key finding: HIGHLIGHTS: PFAS exposure increases cardiometabolic risk factors and neurotoxicity. +4 more findings

Full summary, score breakdown and related studies → Original source

Incidence and Risk Factors of Postoperative Delirium in Elderly Patients Following Hip Fracture Surgery: A Nationwide Retrospective Cohort Study in Taiwan

59/100 ✓ Peer-reviewed How common it is International Journal of Geriatric Psychiatry

Key finding: The incidence of the first episode of delirium after hip surgery in the elderly was 1.87 events per 1000 PYs. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Association of Mediterranean, high-quality, and anti-inflammatory diet with dementia in UK Biobank cohort

54/100 ✓ Peer-reviewed How common it is The journal of nutrition health & aging

Key finding: Over a median follow-up of 13.5 years, 1453 dementia cases were identified. +4 more findings

• Lifestyle
• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

Targeted proteomic biomarker profiling using NULISA in a cohort enriched with risk for Alzheimer's disease and related dementias

58/100 ✓ Peer-reviewed How common it is Alzheimer s & Dementia

Key finding: -fold changes of 1.21, 0.57, and 4.63, respectively, compared to A-. +4 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Enhancing participation of historically minoritized groups in Alzheimer disease and related dementias research: National Conference Report

45/100 ✓ Peer-reviewed Disparities Alzheimer s & Dementia

Key finding: The National Conference described strategies to diversify participation in AD research. +4 more findings

• Health Equity

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Qualitative study exploring knowledge and attitudes towards dementia risk prediction, barriers to dementia services and service improvement recommendations with diverse populations in England

42/100 ✓ Peer-reviewed Disparities BMJ Open

Key finding: Participants possessed some knowledge about dementia but highlighted a need for better access to information about dementia. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Breaking the silence: understanding the unique burden on informal Black male dementia caregivers

36/100 ✓ Peer-reviewed Disparities Alzheimer s & Dementia

Key finding: HIGHLIGHTS: The non-Hispanic Black population in the United States is disproportionately affected by Alzheimer's disease (AD) and AD and related dementias (ADRD), which will increase the demand for caregiving. +4 more findings

• Health Equity
• Caregiving

Full summary, score breakdown and related studies → Original source

Evaluating linked ICD‐10 Medicare claims data as a method of dementia case ascertainment in research settings

55/100 ✓ Peer-reviewed Disparities Alzheimer s & Dementia

Key finding: A total of 1869 participants contributed 5309 observations (mean age 82.9 years, 21.0% Black, 9.3% met research-based dementia criteria). +4 more findings

Full summary, score breakdown and related studies → Original source

Music attuned technology care via eHealth (MATCH): A proof-of-concept study for community-dwelling people living with dementia and caregivers

37/100 ✓ Peer-reviewed Caregiving Digital Health

Key finding: Participants found MATCH acceptable (combined AES median score of 28, range 25-34) and useful (SUS median score of 73.5, range 55-100). +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Assessment of the validity of the Resilience and Strain Questionnaire in Caregivers of People with Dementia (ResQ-Care-Dem): a cross-sectional survey study

45/100 ✓ Peer-reviewed Caregiving BMJ Open

Key finding: The ResQ-Care-Dem scales' internal consistencies ranged between 0.65 and 0.81. +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

LGBTQ+ identity social support and care access among LGBTQ+ caregivers of individuals living with mild cognitive impairment, Alzheimer's disease, and related dementias

48/100 ✓ Peer-reviewed Caregiving Alzheimer s & Dementia

Key finding: Eighty respondents (8.1%) care for 90 individuals with neurocognitive disorders, a majority of whom are parents of the respondent. +4 more findings

• Caregiving
• Early Stage

Full summary, score breakdown and related studies → Original source

Dementia care in a rapidly aging society

45/100 ✓ Peer-reviewed Caregiving Alzheimer s & Dementia

Key finding: Estimates suggest a high social burden from ADRD, with annual costs increasing from 0.9% to 3.8% of gross domestic product between 2019 and 2050. +4 more findings

Full summary, score breakdown and related studies → Original source

Daily interactions with care recipients and cardiovascular reactivity among dementia caregivers: The buffering role of friend interactions

46/100 ✓ Peer-reviewed Caregiving Alzheimer s & Dementia

Key finding: Within-day analyses revealed time with CRs was associated with increased HR, primarily due to negative interactions. +4 more findings

• Caregiving
• Risk Factors

Full summary, score breakdown and related studies → Original source