Polygenic risk for Alzheimer's disease is associated with neuroaxonal damage before onset of clinical symptoms
Sonja M Kagerer, Swapnil Awasthi, Stephan Ripke, Aleksandra Maceski, Pascal Benkert, Aïda B Fall, Peter Riederer, Peter Fischer et al.. Alzheimer's & dementia (Amsterdam, Netherlands), 2024-01-09
Topic: Plasma and spinal-fluid biomarkers
Nineteen participants developed AD after a median of 60 months (interquartile range 30). In participants with AD, baseline NfL plasma levels correlated with PRS-CS (r = 0.75, p < 0.001; difference to controls: Fisher's r-to-z: z = 3.89, p < 0.001). PRS-CS combined with baseline plasma NfL predicted onset of AD (p < 0.01). Our data suggest that polygenic risk for AD and plasma NfL closely interact years before onset of clinical symptoms. Peripheral NfL may serve as a diagnostic measure supporting early therapeutic intervention and secondary prevention in AD.
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APA 7th
Kagerer, S. M., Awasthi, S., Ripke, S., Maceski, A., Benkert, P., Fall, A. B., et al. (2024). Polygenic risk for Alzheimer's disease is associated with neuroaxonal damage before onset of clinical symptoms. Alzheimer's & dementia (Amsterdam, Netherlands). https://doi.org/10.1002/dad2.12504
Vancouver
Kagerer SM, Awasthi S, Ripke S, Maceski A, Benkert P, Fall AB, et al. Polygenic risk for Alzheimer's disease is associated with neuroaxonal damage before onset of clinical symptoms. Alzheimer's & dementia (Amsterdam, Netherlands). 2024. doi:10.1002/dad2.12504. PMID: 38213949.
BibTeX
@article{kagerer2024-38213949,
author = {Kagerer, Sonja M and Awasthi, Swapnil and Ripke, Stephan and Maceski, Aleksandra and Benkert, Pascal and Fall, Aïda B and Riederer, Peter and Fischer, Peter and others},
title = {{Polygenic risk for Alzheimer's disease is associated with neuroaxonal damage before onset of clinical symptoms}},
journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
year = {2024},
doi = {10.1002/dad2.12504},
pmid = {38213949},
url = {https://doi.org/10.1002/dad2.12504}
}
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Key findings
- Nineteen participants developed AD after a median of 60 months (interquartile range 30).
- In participants with AD, baseline NfL plasma levels correlated with PRS-CS (r = 0.75, p < 0.001; difference to controls: Fisher's r-to-z: z = 3.89, p < 0.001).
- PRS-CS combined with baseline plasma NfL predicted onset of AD (p < 0.01).
- Our data suggest that polygenic risk for AD and plasma NfL closely interact years before onset of clinical symptoms.
- Peripheral NfL may serve as a diagnostic measure supporting early therapeutic intervention and secondary prevention in AD.
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Study details
- Study designcohort study
- Evidence strengthModerate
How this study scored 63/100
Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 35 of the 56 points we could judge it on, which is 63 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia (Amsterdam, Netherlands)) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38213949) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 35 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 35 of the 56 points we could judge it on is 63 out of 100. |
| Total | 63 / 100 | — |
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