Newest studies

Potentially Modifiable Risk Factors for Dementia and Mild Cognitive Impairment: An Umbrella Review and Meta-Analysis

79/100 ✓ Peer-reviewed Prevention and risk Dementia and geriatric cognitive disorders

Key finding: A total of 45 reviews with 212 meta-analyses were synthesized. +4 more findings

• Prevention
• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Timing of Biomarker Changes in Sporadic Alzheimer's Disease in Estimated Years from Symptom Onset

65/100 ✓ Peer-reviewed Biomarkers Annals of neurology

Key finding: The use of an amyloid clock enabled visualization and analysis of biomarker changes as a function of estimated years from symptom onset in sporadic AD.

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Neighborhood disadvantage reduces cognitive reserve independent of neuropathologic change

55/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Higher ADI was significantly associated with lower MMSE score. +4 more findings

• Brain Biology
• Health Equity

Full summary, score breakdown and related studies → Original source

The Impact of Anti-Amyloid Immunotherapies on Stroke Care

45/100 ✓ Peer-reviewed Treatments Journal of clinical medicine

Key finding: While these therapies have demonstrated efficacy in clearing amyloid-β and slowing cognitive decline, they have also been associated with amyloid-related imaging abnormalities (ARIA) which include both edema (ARIA-E) and hemorrhage (ARIA-H). +1 more finding

• Treatments

Full summary, score breakdown and related studies → Original source

Mechanisms of sex differences in Alzheimer's disease

41/100 ✓ Peer-reviewed Genetics Neuron

Key finding: Alzheimer's disease (AD) and the mechanisms underlying its etiology and progression are complex and multifactorial. +3 more findings

Full summary, score breakdown and related studies → Original source

High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis

55/100 ✓ Peer-reviewed TREM2 and immune genetics Arteriosclerosis, thrombosis, and vascular biology

Key finding: Atherosclerotic plaques are complex tissues composed of a heterogeneous mixture of cells. +3 more findings

Full summary, score breakdown and related studies → Original source

Assessment of Efficacy and Safety of Zagotenemab: Results From PERISCOPE-ALZ, a Phase 2 Study in Early Symptomatic Alzheimer Disease

72/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: In participants with early symptomatic AD, zagotenemab failed to achieve significant slowing of clinical disease progression compared with placebo. +4 more findings

• Clinical Trials
• Biomarkers
• Side Effects

Full summary, score breakdown and related studies → Original source

Potential impact of unblinding on observed treatment effects in Alzheimer's disease trials

54/100 ✓ Peer-reviewed Clinical trials Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: In trials of lecanemab, aducanumab, and donanemab, incidence of amyloid-related imaging abnormalities with active treatment ranged from 22% to 44%, the vast majority of which presumably led to unblinding. +4 more findings

• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Too Soon or Too Late: Rethinking the Significance of Six Months When Dementia Is a Primary Diagnosis

16/100 ⚠ Report — not peer-reviewed Health systems and care delivery The Hastings Center report

Key finding: Hospice care has become an integral part of the end-of-life care in the United States, but as it has grown, its policies and practices have also imposed cultural narratives, like those associated with the "six-month rule" that the majority of the end of life takes place in the final six months of life.

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Highly accurate blood test for Alzheimer's disease is similar or superior to clinical cerebrospinal fluid tests

74/100 ✓ Peer-reviewed Biomarkers Nature medicine

Key finding: Blood plasma %p-tau217 demonstrated performance that was clinically equivalent or superior to clinically used FDA-approved CSF tests in the detection of AD pathology.

• Biomarkers
• Treatments
• Brain Scans

Full summary, score breakdown and related studies → Original source

General cognitive ability in high school, attained education, occupational complexity, and dementia risk

52/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Education partially mediated the effect of adolescent cognition on CI in the cognitive assessment aample and AD8 in the questionnaire sample (Ps < 0.001). +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Anti-amyloid Antibody Therapies for Alzheimer's Disease

43/100 ✓ Peer-reviewed Treatments Nuclear medicine and molecular imaging

Key finding: Recently completed phase 2 and 3 trials of third-generation anti-amyloid immunotherapies indicated clinical efficacy in significantly reducing brain Aβ load and inhibiting the progression of cognitive decline. +1 more finding

• Treatments
• Clinical Trials
• Brain Scans

Full summary, score breakdown and related studies → Original source

The relationship between amyloid pathology, cerebral small vessel disease, glymphatic dysfunction, and cognition: a study based on Alzheimer's disease continuum participants

50/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer's research & therapy

Key finding: Glymphatic dysfunction is a crucial pathway for dementia. +3 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Association Between Years of Education and Amyloid Burden in Patients With Subjective Cognitive Decline, MCI, and Alzheimer Disease

63/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: Across the cohort of 212 individuals with SCD+ (M(Age) = 69.17 years, F 42.45%), 258 individuals with MCI (M(Age) = 72.93, F 43.80%), and 195 individuals with dementia (M(Age) = 74.07, F 48.72%), no main effect of education (ß = 0.52, 95% CI -0.30 to 1.58), but a significant education-by-group interaction on CL values, was found ( p = 0.024) using linear regression modeling.

• Early Stage

Full summary, score breakdown and related studies → Original source

In vitro evaluation of [3H]PI-2620 and structural derivatives in non-Alzheimer's tauopathies

43/100 ✓ Peer-reviewed Brain scans and imaging Nuclear medicine and biology

Key finding: In PSP tissue [3H]PI-2620 demonstrated the highest affinity (5.3 nM) and in CBD tissue [3H]F-4 bound with the highest affinity (9.4 nM). +1 more finding

• Brain Biology
• Brain Scans

Full summary, score breakdown and related studies → Original source

Down Syndrome-Basque Alzheimer Initiative (DS-BAI): Clinic-Biological Cohort

39/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of clinical medicine

Key finding: Specific health plans for DS and conducting clinical and translational research on the challenges of aging, including AD, are necessary and feasible.

• Down Syndrome

Full summary, score breakdown and related studies → Original source

Ketogenic diet and BHB rescue the fall of long-term potentiation in an Alzheimer's mouse model and stimulates synaptic plasticity pathway enzymes

43/100 ✓ Peer-reviewed Disease mechanisms Communications biology

Key finding: KD significantly rescued Long-Term-Potentiation (LTP) to wild-type levels, not by changing Amyloid-β (Aβ) levels. +4 more findings

• Brain Biology
• Lifestyle

Full summary, score breakdown and related studies → Original source

Nutrition, Exercise, and Cognitive Rehabilitation for Dementia Prevention

43/100 ✓ Peer-reviewed Prevention and risk Juntendo Iji zasshi = Juntendo medical journal

Key finding: Dementia is one of the most significant global challenges in medical and social care in the 21st century.

• Lifestyle
• Prevention
• Risk Factors

Full summary, score breakdown and related studies → Original source

Caregivers' attitudes toward blood-based biomarker testing for Alzheimer's disease

59/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Most caregivers (72.0%) favored BBBM for AD diagnosis. +4 more findings

• Biomarkers
• Caregiving

Full summary, score breakdown and related studies → Original source

Day-to-day sleep variability with Alzheimer's biomarkers in at-risk elderly

50/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Lower cerebrospinal fluid (CSF) ApoE, higher CSF p-tau181/amyloid-β (Aβ)42, and higher plasma p-tau231/Aβ42 were associated with higher variability of sleep midpoint, sleep duration, and/or activity count. +2 more findings

• Biomarkers
• Lifestyle

Full summary, score breakdown and related studies → Original source

Prognostic and Predictive Factors in Early Alzheimer's Disease: A Systematic Review

66/100 ✓ Peer-reviewed Treatments Journal of Alzheimer's disease reports

Key finding: Age was the strongest risk factor for progression. +4 more findings

• Treatments
• Biomarkers

Full summary, score breakdown and related studies → Original source

Particulate matter from car exhaust alters function of human iPSC-derived microglia

43/100 ✓ Peer-reviewed Risk factors Particle and fibre toxicology

Key finding: Here we show that two different PMs derived from exhausts of cars running on EN590 diesel or compressed natural gas (CNG) alter the function of human microglia-like cells in vitro. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Outdoor Nighttime Light Exposure (Light Pollution) is Associated with Alzheimer's Disease

43/100 ✓ Peer-reviewed Risk factors Frontiers in neuroscience

Key finding: Higher outdoor nighttime light was associated with higher prevalence of AD. +2 more findings

• Risk Factors

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Digital neuropsychological measures by defense automated neurocognitive assessment: reference values and clinical correlates

55/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in neurology

Key finding: Age- and sex-specific reference values were generated for three DANA tasks. +4 more findings

• Digital Tools

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Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD

41/100 ✓ Peer-reviewed Brain tissue and pathology Science translational medicine

Key finding: We found that the inclusion of cryptic peptide sequences in proteins altered their interactions with other proteins, thereby likely altering their function. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source