Newest studies

Computerized cognitive training for memory functions in mild cognitive impairment or dementia: a systematic review and meta-analysis

83/100 ✓ Peer-reviewed Prevention trials NPJ digital medicine

Key finding: The results suggest that CCT is efficacious on various memory domains in individuals with MCI.

• Early Stage
• Lifestyle
• Digital Tools

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Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers

48/100 ✓ Peer-reviewed Tau biomarkers BMC neurology

Key finding: In mild AD patients aged less than 75 years, the mean age-at-diagnosis of AD in APOE4 carriers was reduced by over 6 years in BCHE-K carriers versus noncarriers. +4 more findings

• Biomarkers

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Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer's disease

59/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular neurodegeneration

Key finding: We previously reported the MS4A locus as a key modulator for soluble TREM2 (sTREM2) in cerebrospinal fluid (CSF). +3 more findings

• Genetics
• Biomarkers

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scMD facilitates cell type deconvolution using single-cell DNA methylation references

43/100 ✓ Peer-reviewed Genetics Communications biology

Key finding: With scMD-estimated cellular fractions, we identify cell type fractions and cell type-specific differentially methylated cytosines associated with Alzheimer's disease.

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Impaired microglial phagocytosis promotes seizure development

16/100 ⚠ Preprint — not yet peer-reviewed TREM2 and immune genetics bioRxiv : the preprint server for biology

Key finding: Electroencephalographic analysis, immunocytochemistry, and RNA sequencing revealed that TREM2 deficiency significantly promoted seizure-induced pathology. +2 more findings

• Brain Biology

Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Oxidative stress in Alzheimer's disease: current knowledge of signaling pathways and therapeutics

41/100 ✓ Peer-reviewed Treatments Molecular biology reports

Key finding: Oxidative stress induced damage to lipids, proteins and DNA result in neuronal death which leads to AD.

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

The rise of home death in the COVID-19 pandemic: a population-based study of death certificate data for adults from 32 countries, 2012-2021

57/100 ✓ Peer-reviewed End-of-life care EClinicalMedicine

Key finding: The study included 100.7 million people (51.5% male, 68.0% with ≥70 years), 20.4% died from cancer and 5.8% from dementia; 30.8% of deaths took place at home.

• End-of-Life Care

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Digital Clock and Recall is superior to the Mini-Mental State Examination for the detection of mild cognitive impairment and mild dementia

59/100 ✓ Peer-reviewed Digital health tools Alzheimer's research & therapy

Key finding: DCR outperforms the MMSE in detecting and classifying cognitive impairment-in a fraction of the time-while being not influenced by a patient's ethnicity. +4 more findings

• Diagnosis
• Early Stage
• Digital Tools

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Transcranial blood-brain barrier opening in Alzheimer's disease patients using a portable focused ultrasound system with real-time 2-D cavitation mapping

45/100 ✓ Peer-reviewed Biomarkers Theranostics

Key finding: BBBO was achieved in 5 out of 6 subjects with an average volume of 983±626 mm 3 following FUS at the right frontal lobe both in white and gray matter regions. +3 more findings

• Clinical Trials
• Brain Biology

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Identification of Dementia in Medicare Claims Compared to Rigorous Clinical Assessments in African Americans

46/100 ✓ Peer-reviewed Costs and economics The journals of gerontology. Series A, Biological sciences and medical sciences

Key finding: Among 88 African Americans with cognitive impairment (mean = 10 years follow-up), Medicare claims identified dementia <2 years from cohort diagnosis in 55%; 27% were identified 2-9.9 years after cohort diagnosis, and in 18% there was either no claims diagnosis during the study period, or claims identified dementia 10+ years after cohort diagnosis. +3 more findings

• Policy
• Diagnosis
• Health Equity

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A Community-Based Study of Dementia in Mexican American and Non-Hispanic White Individuals

75/100 ✓ Peer-reviewed Disparities Journal of Alzheimer's disease : JAD

Key finding: 1,901 participants completed the MoCA and 547 the HCAP. +4 more findings

• Health Equity

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Understanding Racial Disparities in Dementia Prevalence Among Veterans

43/100 ✓ Peer-reviewed Disparities Journal of Alzheimer's disease : JAD

Key finding: During follow up (mean 11.1 years), 13% of Veterans developed dementia. +4 more findings

• Health Equity
• Risk Factors

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Referral Sources Across Racial and Ethnic Groups at Alzheimer's Disease Research Centers

66/100 ✓ Peer-reviewed Disparities Journal of Alzheimer's disease : JAD

Key finding: Included in the analysis were 48,330 participants across 46 ADRCs (mean [SD] age, 71.3 [10.5] years; 20,767 female [57%]; 4,138 Hispanic [8.6%]; 1,392 non-Hispanic Asian [2.9%]; 6,766 non-Hispanic Black [14%] individuals; and 676 individuals [1.4%] of other races. +3 more findings

• Health Equity

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The Effects of Neuropsychiatric Symptom Clusters in People with Dementia on Family Caregiver Burden

50/100 ✓ Peer-reviewed Caregiving Journal of Alzheimer's disease : JAD

Key finding: Adjusted for functional impairments and sociodemographic variables, neuropsychiatric symptoms were associated with more caregiver burden (p < 0.001). +4 more findings

• Caregiving

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Amyloid Beta-Mediated Neurovascular Toxicity in Alzheimer's Disease

43/100 ✓ Peer-reviewed Vascular contributions Methods in molecular biology (Clifton, N.J.)

Key finding: It is followed by pericyte degeneration which results in dysregulation of cerebral blood flow (CBF), neurovascular uncoupling, and BBB breakdown.

• Brain Biology
• Side Effects

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Monogenic causes of cerebral small vessel disease and stroke

43/100 ✓ Peer-reviewed Vascular contributions Handbook of clinical neurology

Key finding: In a small number of patients, cSVDs result from monogenic diseases, the most frequent being cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). +1 more finding

• Other Dementias
• Genetics

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Intestinal Barrier Function and Neurodegenerative Disease

43/100 ✓ Peer-reviewed Disease mechanisms CNS & neurological disorders drug targets

Key finding: As one of the first lines of defense between the body and the external environment, the impaired function of the intestinal barrier is closely related to the development of neurodegenerative pathologies. +4 more findings

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Gut Microbiome in Alzheimer's Disease: from Mice to Humans

43/100 ✓ Peer-reviewed Disease mechanisms Current neuropharmacology

Key finding: Recent preclinical studies and clinical evidence indicate that changes in the gut microbiome could potentially play a role in the accumulation of amyloid beta.

• Brain Biology

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Microglial TLR4/NLRP3 Inflammasome Signaling in Alzheimer's Disease

43/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Alzheimer's disease : JAD

Key finding: As the primary cells of innate immunity in the central nervous system, microglia play a key role in neuroinflammation. +4 more findings

• Brain Biology

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Social Loneliness in Older Adults with Mild Cognitive Impairment: Predictive Factors and Associated Clinical Characteristics

52/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD

Key finding: The predictors of the Social Loneliness factors were as follows; 1) perceived social support (R2 = 0.33): Neuroticism (β= 0.353), depression (β= 0.205), and perceived health (β= 0.133); 2) social participation (R2 = 0.24): Conscientiousness (β= -0.344) and Extraversion (β= -0.263); 3) use of communication technologies (R2 = 0.44): age (β= 0.409), type of cohabitation (β= 0.331), cognitive reserve (β= -0.303), and Conscientiousness (β= -0.247); all p < 0.05. +2 more findings

• Early Stage
• Lifestyle

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Tipping the Balance Between Cognitive Reserve, Frailty, and Dementia in the Very Old?

52/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD

Key finding: 166 patients were consecutively enrolled (mean age was 85.7 years old, females composed 68%); 25% had a diagnosis of amnestic mild cognitive impairment, and 75% had a diagnosis of dementia. +4 more findings

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Impact of Concurrent Visual and Hearing Impairment on Incident Alzheimer's Disease: The LIFE Study

61/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD

Key finding: Among 14,186 participants, we identified 1,194 (8.4%) who developed AD over a median follow-up period of 22.6 months. +4 more findings

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China Initiative for Multi-Domain Intervention (CHINA-IN-MUDI) to Prevent Cognitive Decline: Study Design and Progress

80/100 ✓ Peer-reviewed Prevention trials The journal of prevention of Alzheimer's disease

Key finding: Currently, 1,965 participants have been randomized into lifestyle intervention (n = 772) and control groups (n = 1,193). +4 more findings

• Clinical Trials
• Prevention

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Programme Dementia Prevention (pdp): A Nationwide Program for Personalized Prevention in Luxembourg

59/100 ✓ Peer-reviewed Prevention trials Journal of Alzheimer's disease : JAD

Key finding: A total number of 450 participants (Mean age = 69.5 years; SD = 10.8) have been screened at different recruitment sites throughout the country, among whom 425 participants (94.4%) met the selection criteria. +1 more finding

• Prevention

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[Mechanism of action and clinical trial results of Lecanemab (Leqembi® 200 ‍mg, 500 ‍mg for Intravenous Infusion), a novel treatment for Alzheimer's disease]

43/100 ✓ Peer-reviewed Clinical trials Nihon yakurigaku zasshi. Folia pharmacologica Japonica

Key finding: It was developed for the treatment of early Alzheimer's disease (mild cognitive impairment or mild dementia stage of Alzheimer's disease). +4 more findings

• Clinical Trials
• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source