Newest studies

Targeted demethylation of cathepsin D via epigenome editing rescues pathology in Alzheimer's disease mouse model

43/100 ✓ Peer-reviewed Biomarkers Theranostics

Key finding: Treatment with Ctsd-targeted dCas9-Tet1 in primary neurons overexpressing mutant APP (mutAPP) reduced Aβ peptide levels and the Aβ42/40 ratio. +2 more findings

• Brain Biology

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Blarcamesine for the treatment of Early Alzheimer's Disease: Results from the ANAVEX2-73-AD-004 Phase IIB/III trial

84/100 ✓ Peer-reviewed Biomarkers The journal of prevention of Alzheimer's disease

Key finding: Blarcamesine, demonstrating a safety profile with no associated neuroimaging adverse events, significantly slowed clinical progression by 36.3% at 48 weeks with blarcamesine group as well as the individual 30 mg (by 34.6%) and 50 mg (by 38.5%) blarcamesine groups vs. placebo on the prespecified primary cognitive endpoint ADAS-Cog13. +4 more findings

• Clinical Trials
• Treatments

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The Effect of APOE ε4 on Alzheimer's Disease Fluid Biomarkers: A Cross-Sectional Study Based on the COAST

41/100 ✓ Peer-reviewed Inflammation and the immune system CNS neuroscience & therapeutics

Key finding: APOE ε4 is associated with accelerated progression of AD pathology. +2 more findings

• Biomarkers
• Genetics

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Scaling of Small-Area Fair Market Rents: Evidence on Neighborhood Choices of Voucher Recipients

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors Not indexed

Key finding: These results underscore the importance of accounting for implementation environments when scaling housing policy.

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The Leading Neighborhood-Level Predictors of Drug Overdose: A Mixed Machine Learning and Spatial Approach

15/100 ⚠ Preprint — not yet peer-reviewed Risk factors Not indexed

Key finding: Our results showed that XGBoost was the top-performing modeling approach for each domain. +4 more findings

• Treatments

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Neighborhood Spatial Social Polarization and Dementia Disparities Among U.S. Medicare Beneficiaries

32/100 ✓ Peer-reviewed Risk factors Alzheimer's & Dementia

Key finding: SSP is a flexible and predictive neighborhood‐level measure of health disparities compared to indices like the Gini coefficient. +4 more findings

• Health Equity

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The Role of Medicare Insurance Coverage Type in Annual Wellness Visits: A Comparison between Traditional Medicare and Medicare Advantage Plan

32/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer's & Dementia

Key finding: Enrollment in an MA plan is associated with a higher probability of AWV uptake, particularly among vulnerable populations from racial and ethnic minorities, dual eligibility, and those diagnosed with ADRD. +3 more findings

• Policy
• Health Equity

Full summary, score breakdown and related studies → Original source

Role of PCPs in diagnosing dementia in traditional Medicare and Medicare Advantage

42/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer's & Dementia

Key finding: Differences in system‐level factors such as access to dementia specialists is a contributing factor to differences in diagnosis rates in MA and TM. +2 more findings

• Policy
• Diagnosis

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Impact of PM2.5 on Cardiovascular Disease, Dementia, and Stroke in Older Kidney Transplant Recipients

34/100 ✓ Peer-reviewed Vascular contributions American Journal of Transplantation

Key finding: Exposure to fine particulate matter (PM ) pollution is associated with negative health outcomes including dementia, cardiovascular disease (CVD), and stroke due to increased levels of oxidative stress and inflammation among community-dwelling older adults.

• Risk Factors

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Pharmacotherapy for Poststroke Cognitive Impairment and Poststroke Cognitive Impairment With Dementia: A Review

38/100 ✓ Peer-reviewed Vascular contributions Stroke Research and Treatment

Key finding: Poststroke cognitive impairment (PSCI) refers to any level of cognitive decline occurring after a stroke, ranging from mild to severe impairments, while PSCI with dementia describes a more severe form where the cognitive decline significantly affects daily functioning and meets the clinical criteria for dementia. +1 more finding

• Treatments

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Clinically meaningful outcomes in Alzheimer's disease and Alzheimer's disease related dementias trials

39/100 ✓ Peer-reviewed Vascular contributions Alzheimer s & Dementia Translational Research & Clinical Interventions

Key finding: On March 12–14, 2024, the National Institute on Aging (NIA) together with the National Institute of Neurological Disorders and Stroke (NINDS) led a workshop exploring clinically meaningful changes in the context of Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD) clinical trials ( https://www.nia.nih.gov/research/dbsr/workshops/clinically‐meaningful‐outcomes‐ad‐adrd‐trials ). +4 more findings

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Greater White Matter Hyperintensities and More Severe Cognitive Dysfunction in Mild Cognitive Impairment With Motoric Cognitive Risk Syndrome

35/100 ✓ Peer-reviewed Vascular contributions Journal of Korean Medical Science

Key finding: < 0.0036), the MCRS group exhibited significantly worse performance on word list memory, word list recall, and MMSE-KC compared to the MCI group without slow gait. +1 more finding

• Early Stage

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Investigating links between white matter hyperintensities and menopausal status using robust age-correction methods in UK Biobank

49/100 ✓ Peer-reviewed Vascular contributions Brain Communications

Key finding: Our results pertaining to menopause-related characteristics, such as age at menopause or menopause hormonal therapy, did not replicate the literature reporting an association with WMH volumes. +4 more findings

• Risk Factors
• Brain Scans

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Unraveling Homocysteine's Role in Dementia: No Specific Association with Alzheimer's Disease, but a Connection to White Matter Hyperintensities

47/100 ✓ Peer-reviewed Vascular contributions Aging and Disease

Key finding: There was no significant association between Hcy tertiles and CSF AD biomarkers. +1 more finding

• Brain Scans
• Biomarkers

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Association of mid-life cardiovascular risk with biomarkers of Alzheimer's disease, neurodegeneration, and white matter hyperintensities: Heart SCORE brain study

42/100 ✓ Peer-reviewed Vascular contributions Journal of Alzheimer s Disease Reports

Key finding: 6.98 [2.44-19.95]; p < 0.05) driven primarily by self-identified Black race and age, while none with A and T. +3 more findings

• Risk Factors

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FDG-PET anterior cingulate cortex hypometabolism as a marker of cerebral small vessel disease in Alzheimer's and vascular cognitive impairment and dementia

41/100 ✓ Peer-reviewed Vascular contributions Cerebral Circulation - Cognition and Behavior

Key finding: • Anterior cingulate cortex (ACC) hypometabolism is a non-specific finding in many brain disorders. • ACC hypometabolism was more common in vascular cognitive impairment and dementia (VCID) than Alzheimer dementia (AD). • ACC hypometabolism correlated with cerebral small vessel disease markers. • ACC hypometabolism may be associated with motor stereotypies in VCID. • FDG-PET patterns of hypometabolism may identify vascular contributions to cognitive impairment The anterior cingulate cortex (ACC) is an important hub in the executive and salience networks. +1 more finding

• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Endothelial progenitor cells and cerebral small vessel disease in APOE4 carriers

39/100 ✓ Peer-reviewed Vascular contributions Cerebral Circulation - Cognition and Behavior

Key finding: • APOE4 carriers exhibit cerebrovascular dysfunction. • Endothelial progenitor cells (EPC) represent cell populations involved in facilitating vascular repair. • In APOE4 carriers, EPC colony count is associated with cerebral small vessel disease. • EPC colony count may indicate activation of mechanisms which protect cerebrovascular function in APOE4 carriers prior to the development of cognitive decline. +3 more findings

• Other Dementias

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Perivascular spaces, diffusion MRI markers and cognitive decline in cerebral small vessel disease

53/100 ✓ Peer-reviewed Vascular contributions Cerebral Circulation - Cognition and Behavior

Key finding: Cohort 1 included 446 individuals (mean age (SD) 65.2 years (8.9); 203 women), Cohort 2 included 164 individuals (mean age (SD) 49.9 years (12.6); 88 women). +4 more findings

• Other Dementias
• Risk Factors

Full summary, score breakdown and related studies → Original source

Cerebral Small Vessel Disease: Current and Emerging Therapeutic Strategies

36/100 ✓ Peer-reviewed Vascular contributions Aging and Disease

Key finding: Cerebral small vessel disease (CSVD) is a common disease in older people, characterized by damage to intracranial microvessels, leading to cognitive decline, increased risk of stroke, and dementia.

• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

The Aging Population and Dementia: The Need for Comprehensive Palliative Care

27/100 ✓ Peer-reviewed End-of-life care Acta medica Indonesiana

Key finding: This disease not only impacts the individual but also has significant consequences for their families and caregivers.

• End-of-Life Care

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Dementia in palliative care

26/100 ✓ Peer-reviewed End-of-life care Medycyna Paliatywna

Key finding: Otępienie to zespół objawów wywołany postępującymi chorobami neurodegeneracyjnymi mózgu, które prowadzą do znacznego pogorszenia funkcji poznawczych, a w końcowym etapie do całkowitej zależności pacjenta od otoczenia. +1 more finding

• End-of-Life Care

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Shaping a knowable event or embracing a mysterious journey: A mixed methods study on palliative care clinician views on voluntary assisted dying

35/100 ✓ Peer-reviewed End-of-life care Palliative & Supportive Care

Key finding: Of 142 respondents, 53% supported, 10% were uncertain, and 37% opposed legalizing euthanasia for terminal illness with severe symptoms. +4 more findings

• End-of-Life Care

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Assessment of end-of-life care needs among patients with incurable diseases in Bangladesh: A multicenter study

41/100 ✓ Peer-reviewed End-of-life care Palliative & Supportive Care

Key finding: All patients had a Needs Near the End-of-Life Care Screening (NEST-13) score ≥30, indicating a high level of EOL care need. +3 more findings

• End-of-Life Care

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Suffering and loss in Lewy body dementia: Applying a palliative care lens to a longitudinal narrative study

44/100 ✓ Peer-reviewed End-of-life care Palliative & Supportive Care

Key finding: Participants with Lewy body dementia described losses associated with communication, continence, and energy leading to a progressive loss of independence. +4 more findings

• End-of-Life Care
• Other Dementias

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Exploring advance care planning discourses in scottish dementia policies: A critical discourse analysis

30/100 ✓ Peer-reviewed End-of-life care Social Sciences & Humanities Open

Key finding: The analysis revealed that dementia policies inadequately supported the initiation and revision of ACPs for PwD. +1 more finding

• End-of-Life Care
• Policy

Full summary, score breakdown and related studies → Original source