Newest studies

Network-level functional connectivity is associated with longitudinal tau accumulation and amyloid-dependent cognitive decline in preclinical Alzheimer’s disease

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging Research Square

Key finding: Amyloid-β and tau, pathological hallmarks of AD, silently accumulate years before clinical symptoms’ onset and are associated with neuronal dysfunction and cognitive impairment. +2 more findings

• Brain Scans
• Early Stage

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Race-Specific Dementia Risk Prediction Using 2024 Lancet Commission Risk Factors and Resting Heart Rate: A Survival Analysis of 55,004 NACC Participants

16/100 ⚠ Preprint — not yet peer-reviewed Disparities medRxiv (preprint)

Key finding: RSF consistently outperformed Cox models across all racial groups and prediction horizons, achieving 5-year AUCs of 0.88-0.91 compared with 0.69-0.81 for Cox models. +1 more finding

• Risk Factors
• Health Equity

Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Baseline Statin Exposure and Incident Acute Myocardial Infarction in Adults Aged >=75 Years Without Prior Cardiovascular Disease: A Population-Based Cohort Study

16/100 ⚠ Preprint — not yet peer-reviewed Prevention and risk medRxiv (preprint)

Key finding: In the fully adjusted Cox model, baseline statin exposure was associated with a lower risk of incident AMI (HR, 0.805; 95% CI, 0.731-0.887). +2 more findings

• Risk Factors

Scored 41 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Region-specific cerebral blood flow differentiates cognitively impaired and unimpaired individuals with core Alzheimer's disease pathology

16/100 ⚠ Preprint — not yet peer-reviewed Genetics medRxiv (preprint)

Key finding: NDAN, like Controls, had significantly higher CBF than AD+MCI in GM regions susceptible to neurofibrillary tangle formation in early AD (frontal and temporal cortices, and limbic regions (ps<0.05)).

• Brain Scans
• Early Stage

Scored 37 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Metabolomic signatures of data-driven type 2 diabetes subtypes and their associations with dementia and stroke risk

16/100 ⚠ Preprint — not yet peer-reviewed Prevention and risk medRxiv (preprint)

Key finding: We examined whether their metabolomic profiles also differed and whether subtype-related metabolic patterns were associated with dementia, stroke, and all-cause mortality. +4 more findings

Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Participant attitudes toward returning individual results from CADASIL research

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging medRxiv (preprint)

Key finding: Expert guidance advises caution about disclosing individual research results (IRR), but participant interest remains high even when IRR may not inform individual prognosis. +3 more findings

• Brain Scans

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Detecting Self-Repairs from Spontaneous Speech with Prompt Ablation Across LLMs and Fine-Tuned Encoder

16/100 ⚠ Preprint — not yet peer-reviewed Brain tissue and pathology medRxiv (preprint)

Key finding: These results suggest that a locally deployable encoder, given sufficient in-domain annotation, is a more plausible route to clinical self-repair detection than scaling model size or prompt complexity.

Scored 20 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Age-Related Prevalence of Abnormal Plasma p-Tau217 Across Racial Ethnic Groups in the Health and Aging Brain Study-Health Disparities

48/100 ✓ Peer-reviewed Biomarkers Neurology Open Access

Key finding: Older age was associated with greater odds of abnormal p-Tau217 (odds ratio [OR] 1.08 per year, 95% CI 1.07–1.09), as was APOE ε4 carrier status (OR 3.32, 95% CI 2.65–4.17). +4 more findings

• Biomarkers
• Health Equity

Full summary, score breakdown and related studies → Original source

Adiposity and the Alzheimer Disease–Related Blood Biomarker, p-Tau217, in Community-Dwelling Midlife Women

31/100 ✓ Peer-reviewed Biomarkers Neurology Open Access

Key finding: Women have twice the dementia risk compared with men.

• Biomarkers
• Risk Factors

Full summary, score breakdown and related studies → Original source

Calibration-Aware and Interpretable Graph Learning for Multi-Cohort Diffusion Connectome Brain-Age Modeling

16/100 ⚠ Preprint — not yet peer-reviewed Long-term cohort studies bioRxiv

Key finding: Age-bias-corrected brain-age gap was most consistently associated with reduced diffusion-derived microstructural integrity and structural-network organization across cohorts. +1 more finding

Scored 45 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Privacy Protection of Mental Health Information in China's Electronic Medical Records: A Keyword‑Based Desensitization Method

16/100 ⚠ Preprint — not yet peer-reviewed How common it is Research Square

Key finding: While the widespread adoption of electronic medical records (EMRs) has significantly improved healthcare efficiency and resource allocation, the sensitivity of medical data poses serious privacy breach risks. +1 more finding

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Reliability and disease sensitivity are dissociable properties of EEG foundation-model representations

16/100 ⚠ Preprint — not yet peer-reviewed Lewy body dementia bioRxiv

Key finding: Only the reliability half of that contrast is individually significant. +1 more finding

Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Global Research Landscapes and Emerging Trends in Music Therapy for Older Adults: A Comprehensive Bibliometric Analysis

52/100 ✓ Peer-reviewed Health systems and care delivery F1000Res

Key finding: Research on music therapy for older adults is a rapidly expanding and involves strong global collaboration. +1 more finding

• Treatments

Full summary, score breakdown and related studies → Original source

Autophagy Stimulation by Intermittent Fasting and Its Potential Neuroprotective Role in Alzheimer’s Disease

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors Preprints.org

Key finding: Evidence from in vitro models and animal studies suggests that fast-ing-induced metabolic switching, particularly β-hydroxybutyrate production, can modulate AMPK–mTOR signalling, autophagic flux, oxidative stress, synaptic plas-ticity and Aβ/Tau-related proteostasis. +1 more finding

• Brain Biology

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Hepatic and Brain Spatial Gene Expression Changes in Intragastric Alcohol Fed APP/PS1 Alzheimer's Disease Mouse Model

16/100 ⚠ Preprint — not yet peer-reviewed Drug development Research Square

Key finding: These findings implicate significant liver–brain crosstalk through which chronic alcohol exposure may modulate AD-relevant pathology and reinforce the growing recognition of the liver as a critical organ in AD pathogenesis. +4 more findings

• Brain Biology
• Genetics
• Lifestyle

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Public-Data Reanalysis Links MS4A4A to M2-like Human Myeloid States and Supports a Predicted Four-Pass Transmembrane Fold

16/100 ⚠ Preprint — not yet peer-reviewed TREM2 and immune genetics bioRxiv

Key finding: MS4A4A was higher in M2 (IL-4) than in M1 (IFN-γ + LPS) macrophages in all three donors (log2 fold change +2.68, adjusted P = 0.0013). +4 more findings

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Quantitative Systems Pharmacology Analysis of Amyloid Aggregation and Hippocampal Atrophy Trajectories in Alzheimer’s Disease by APOE4 Genotype and Valiltramiprosate/ALZ-801 Treatment

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers Research Square

Key finding: Model predictions were validated against the plasma Aβ42/Aβ40 results from the valiltramiprosate Phase 2 study and HV outcomes from APOLLOE4. +3 more findings

• Treatments
• Clinical Trials
• Biomarkers

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Investigating the Usability, Feasibility, and Effect of a Virtual Reality Cognitive Training System on Brain Cancer Patients with Mild Cognitive Impairment: A Quasi-Experimental (Single-Arm) Pilot Study

16/100 ⚠ Preprint — not yet peer-reviewed Mild cognitive impairment medRxiv (preprint)

Key finding: The feasibility criteria of >80% was met. +4 more findings

• Early Stage
• Digital Tools

Scored 26 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Glucagon-like peptide-1 receptor agonist initiation and risk of clinically recorded Alzheimer's disease-type dementia in older adults with type 2 diabetes: a target trial emulation using causal machine learning

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools medRxiv (preprint)

Key finding: Despite established metabolic, cardiovascular, and renal benefits, it remains uncertain whether GLP-1 receptor agonists are associated with longer clinically recorded Alzheimers disease (AD)-type dementia-free survival than sulfonylureas (SU) or SGLT2 inhibitors. +4 more findings

• Digital Tools
• Risk Factors

Scored 30 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Antidiabetic medications and risk of cognitive disorders in type 2 diabetes: A retrospective cohort study

55/100 ✓ Peer-reviewed Drug development PLoS ONE

Key finding: Among 1,528,885 adults with type 2 diabetes (mean age, 58 years; 49.2% women), GLP-1 receptor agonists plus metformin were associated with lower incidence of vascular dementia (HR, 0.46; 95% CI, 0.37-0.57), mild cognitive disorder (HR, 0.79; 95% CI, 0.66-0.95), and Alzheimer disease (HR, 0.46; 95% CI, 0.31-0.70). +4 more findings

• Treatments
• Risk Factors

Full summary, score breakdown and related studies → Original source

Identification of prevalent dementia in Medicare Advantage encounters, compared with rigorous cohort assessments

48/100 ✓ Peer-reviewed Health systems and care delivery The Journals of Gerontology Series A

Key finding: Of the 508 eligible MA enrollees, mean age was 82.8 (SD = 7.2) years, 81% were female, and 49% were non-Latino White; 62 participants (12%) were classified as having dementia by the cohort assessment. +4 more findings

Full summary, score breakdown and related studies → Original source

Conditional polygenic enrichment distinguishes causal from tagging disease-critical cell populations in single-cell RNA-seq

16/100 ⚠ Preprint — not yet peer-reviewed Genetics medRxiv (preprint)

Key finding: Examples include subpopulations of CD4+ T cells associated with inflammatory bowel disease, characterized by enrichment for a multi-cytokine phenotype and overlap with the naive NF-kB-activated, central memory, and effector memory CD4+ T subtypes, and subpopulations of microglia associated with Alzh +2 more findings

• Genetics

Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Enhancing Emergency Care for Persons Living with Dementia: Innovation and Age-friendly Approaches in Three Emergency Departments

16/100 ⚠ Preprint — not yet peer-reviewed Risk genes beyond APOE medRxiv (preprint)

Key finding: KEY POINTSO_LIThis paper demonstrates the feasibility of implementing Geriatric ED programs with targeted support for people living with or at risk for dementia across three distinct health systems in San Francisco. +4 more findings

• Care Services

Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

MRI-derived brain aging trajectories across the Alzheimer's continuum: links to cognition, pathology and lifestyle risk factors

16/100 ⚠ Preprint — not yet peer-reviewed Prevention and risk medRxiv (preprint)

Key finding: Higher BAG was associated with poorer baseline cognition and predicted cognitive decline, with strongest effects in A{beta}+T+. +1 more finding

• Brain Scans
• Prevention
• Risk Factors

Scored 38 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Quantifying Uncertainty in Alzheimer's Disease Progression Modelling: A Variational Disease Progression Score Framework

16/100 ⚠ Preprint — not yet peer-reviewed Getting a diagnosis medRxiv (preprint)

Key finding: Using the ADNI dataset, we found that the model realigned patients according to their clinical diagnoses.

Scored 33 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source