Newest studies

Cochlear Implants Now More Accessible to Older Adults

28/100 ✓ Peer-reviewed Risk factors The Hearing Journal

Key finding: Benefits Beyond Auditory Rehabilitation Research conducted by Frank Lin and colleagues found that individuals with untreated mild, moderate, and severe hearing loss had, respectively, a twofold, threefold, and fivefold increased risk of dementia compared with individuals with normal hearing. 4 Research suggests that early auditory rehabilitation is important for people of all ages, including older adults, as it can provide benefits and improvements beyond hearing ability such as cognitive function and mitigation of depression. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Emerging therapeutics agents and recent advances in drug repurposing for Alzheimer's disease

41/100 ✓ Peer-reviewed Drug development Ageing research reviews

Key finding: AD is a progressive age-related neurodegenerative disease most often associated with memory deficits and cognition that get more worsen over time. +1 more finding

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Recent diagnostic techniques for the detection of Alzheimer's disease: a short review

41/100 ✓ Peer-reviewed Biomarkers Irish journal of medical science

Key finding: Dementia is characterized by the formation of senile plaques and neurofibrillary tangles, which is followed by neurotoxicity, which results in memory loss and mortality.

• Diagnosis
• Biomarkers
• Treatments

Full summary, score breakdown and related studies → Original source

INPP5D deficiency attenuates amyloid pathology in a mouse model of Alzheimer's disease

45/100 ✓ Peer-reviewed TREM2 and immune genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: A non-coding variant (rs35349669) in INPP5D increases the risk for Alzheimer's disease (AD), and elevated INPP5D expression is associated with increased plaque deposition. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Evaluation of blood-based, extracellular vesicles as biomarkers for aging-related TDP-43 pathology

55/100 ✓ Peer-reviewed Brain tissue and pathology Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: TDP-43 was significantly elevated in plasma ADEVs derived from autopsy confirmed LATE-NC subjects, with or without comorbid AD pathology. +3 more findings

• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

Vascular contributions to Alzheimer's disease

57/100 ✓ Peer-reviewed Vascular contributions Translational research : the journal of laboratory and clinical medicine

Key finding: At neuroimaging, signs of vascular dysfunction such as chronic cerebral hypoperfusion have been demonstrated, appearing early in AD, even before cognitive decline and alteration of traditional biomarkers.

• Other Dementias

Full summary, score breakdown and related studies → Original source

Speech biomarkers of risk factors for vascular dementia in people with mild cognitive impairment

48/100 ✓ Peer-reviewed Risk factors Frontiers in human neuroscience

Key finding: We found that some speech parameters of frequencies and syllabic rhythm vary due to these pathologies. +4 more findings

• Risk Factors
• Biomarkers

Full summary, score breakdown and related studies → Original source

Soluble TREM2 levels associate with conversion from mild cognitive impairment to Alzheimer's disease

52/100 ✓ Peer-reviewed TREM2 and immune genetics The Journal of clinical investigation

Key finding: This study aimed to explore sTREM2 as a central and peripheral predictor of the conversion from mild cognitive impairment (MCI) to AD.METHODSsTREM2 and Aβ1-42 levels in cerebrospinal fluid (CSF) and florbetapir-PET (AV45) images were analyzed for healthy control (HCs), patients with MCI, and patients with AD from the ADNI database. +3 more findings

• Early Stage
• Genetics

Full summary, score breakdown and related studies → Original source

Plasma phosphorylated tau181 predicts cognitive and functional decline

50/100 ✓ Peer-reviewed Biomarkers Annals of Clinical and Translational Neurology

Key finding: Plasma p‐tau181 differentiated pathology‐confirmed AD from NC with negative amyloid PET scans with an AUC of 0.93. +4 more findings

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SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex

41/100 ✓ Peer-reviewed Drug development Acta neuropathologica communications

Key finding: Thus, these novel results demonstrate that the function of αSyn on memory differs between male and female brains.

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Role of Endogenous Lipopolysaccharides in Neurological Disorders

43/100 ✓ Peer-reviewed Disease mechanisms Cells

Key finding: An impaired BBB allows the translocation of potentially harmful bacterial products, including LPS, and activated neutrophils/leucocytes into the brain, which results in neuroinflammation and apoptosis.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Deep learning-based speech analysis for Alzheimer's disease detection: a literature review

43/100 ✓ Peer-reviewed Digital health tools Alzheimer's research & therapy

Key finding: Fifty-two papers were finally retained after screening. +1 more finding

• Digital Tools

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Tau-PET is superior to phospho-tau when predicting cognitive decline in symptomatic AD patients

50/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Baseline tau-PET and a composite baseline cognitive score were the strongest independent predictors of cognitive decline. +3 more findings

• Brain Scans
• Biomarkers
• Genetics

Full summary, score breakdown and related studies → Original source

Therapeutic anti-amyloid β antibodies cause neuronal disturbances

41/100 ✓ Peer-reviewed Drug development Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Recent published clinical trial safety data showed that 41% of Alzheimer patients experienced amyloid-related imaging abnormalities (ARIA), marks of microhemorrhages and edema in the brain, following administration of Biogen's Aduhelm/aducanumab (amino acids 3-7 of the Aβ peptide). +3 more findings

• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

Models of microglia depletion and replenishment elicit protective effects to alleviate vascular and neuronal damage in the diabetic murine retina

44/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of neuroinflammation

Key finding: Therefore, utilizing two models of microglia depletion, we aimed to deplete and repopulate microglia to clarify the contribution of microglia to neuronal loss and vascular damage in the diabetic retina in an STZ-induced model of hyperglycemia. +3 more findings

• Brain Biology
• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development

53/100 ✓ Peer-reviewed TREM2 and immune genetics Immunity

Key finding: However, it remains unclear how such a low-grade, yet persistent, inflammation is sustained in the liver. +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Population-Based Estimates of 1-Year Mortality After Major Surgery Among Community-Living Older US Adults

61/100 ✓ Peer-reviewed Disparities JAMA surgery

Key finding: From 2011 to 2017, of the 1193 major surgeries (from 992 community-living participants), the mean (SD) age was 79.2 (7.1) years; 665 were women (55.7%), and 30 were Hispanic (2.5%), 198 non-Hispanic Black (16.6%), and 915 non-Hispanic White (76.7%).

Full summary, score breakdown and related studies → Original source

CSF P-Tau181 and Other Biomarkers in Patients With Neuronal Intranuclear Inclusion Disease

55/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: CSF p-tau181 was increased in patients with NIID without amyloid accumulation. +3 more findings

• Biomarkers
• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

LATE-NC staging in routine neuropathologic diagnosis: an update

45/100 ✓ Peer-reviewed Brain tissue and pathology Acta neuropathologica

Key finding: Neuroanatomical regions of interest in LATE-NC are described in detail and the implications for TDP-43 immunohistochemical results are specified more precisely.

• Brain Biology
• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

Synaptic degeneration in Alzheimer disease

40/100 ✓ Peer-reviewed Disease mechanisms Nature reviews. Neurology

Key finding: The disease results in brain atrophy caused by neuronal loss and synapse degeneration. +1 more finding

• Brain Biology

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From degenerative disease to malignant tumors: Insight to the function of ApoE

41/100 ✓ Peer-reviewed Genetics Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Key finding: Due to genetic polymorphisms of ApoE (ε2, ε3, and ε4), its three common structural isoforms (ApoE2, ApoE3, ApoE4) are also associated with the risk of many diseases, especially degenerative diseases, such as vascular degenerative diseases including atherosclerosis (AS), coronary heart disease (CHD), and neurodegenerative disease like Alzheimer's disease (AD). +1 more finding

• Genetics

Full summary, score breakdown and related studies → Original source

Association of MRI Indices of Glymphatic System With Amyloid Deposition and Cognition in Mild Cognitive Impairment and Alzheimer Disease

64/100 ✓ Peer-reviewed Genetics Neurology

Key finding: Our study indicates that changes in PVS-related MRI parameters occur in MCI and AD, possibly due to impairment of the glymphatic system. +2 more findings

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia

47/100 ✓ Peer-reviewed Digital health tools Nature communications

Key finding: Mixed results are emerging from prior observational studies. +1 more finding

• Treatments

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Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons

45/100 ✓ Peer-reviewed Inflammation and the immune system Acta neuropathologica

Key finding: In CA1, NLRP3-positive microglia and cleaved GSDMD-positive neurons were associated with local neuronal loss, indicating a possible contribution of NLRP3 inflammasome and pyroptosis activation to AD-related neurodegeneration. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Causal association between systemic lupus erythematosus and the risk of dementia: A Mendelian randomization study

41/100 ✓ Peer-reviewed Genetics Frontiers in immunology

Key finding: No significant causal association was found between SLE and any type of dementia, including Alzheimer's disease, vascular dementia, frontotemporal dementia, and dementia with Lewy bodies. +2 more findings

• Other Dementias
• Risk Factors

Full summary, score breakdown and related studies → Original source