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The Importance of Complement-Mediated Immune Signaling in Alzheimer's Disease Pathogenesis
Batista AF, Khan KA, Papavergi MT, Lemere CA.. International journal of molecular sciences, 2024-01-09
Topic: Amyloid, tau and blood-test diagnosis
As an essential component of our innate immune system, the complement system is responsible for our defense against pathogens. The complement cascade has complex roles in the central nervous system (CNS), most of what we know about it stems from its role in brain development. However, in recent years, numerous reports have implicated the classical complement cascade in both brain development and decline.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Batista, A. F., Khan, K. A., Papavergi, M. T., & Lemere, C. A. (2024). The Importance of Complement-Mediated Immune Signaling in Alzheimer's Disease Pathogenesis. International journal of molecular sciences. https://doi.org/10.3390/ijms25020817
Vancouver
Batista AF, Khan KA, Papavergi MT, Lemere CA. The Importance of Complement-Mediated Immune Signaling in Alzheimer's Disease Pathogenesis. International journal of molecular sciences. 2024. doi:10.3390/ijms25020817. PMID: 38255891.
BibTeX
@article{batista2024-38255891,
author = {Batista, A. F. and Khan, K. A. and Papavergi, M. T. and Lemere, C. A.},
title = {{The Importance of Complement-Mediated Immune Signaling in Alzheimer's Disease Pathogenesis}},
journal = {International journal of molecular sciences},
year = {2024},
doi = {10.3390/ijms25020817},
pmid = {38255891},
url = {https://doi.org/10.3390/ijms25020817}
}
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Key findings
- The complement cascade has complex roles in the central nervous system (CNS), most of what we know about it stems from its role in brain development.
- However, in recent years, numerous reports have implicated the classical complement cascade in both brain development and decline.
- More specifically, complement dysfunction has been implicated in neurodegenerative disorders, such as Alzheimer's disease (AD), which is the most common form of dementia.
- Synapse loss is one of the main pathological hallmarks of AD and correlates with memory impairment.
Why it matters
This review discusses how the complement system, part of innate immunity, has been implicated in brain development and decline and in Alzheimer's disease, where synapse loss is a main feature. It reports no treatment, cure or prevention.
New to this subject? Start with our plain-English guide: Genetics →
Study details
- Evidence strengthLow
How this study scored 51/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (International journal of molecular sciences) |
| Journal's citation record | 3 / 4 | International Journal of Molecular Sciences: journal h-index 426 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 67 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 16.8 citations a year over 4 year(s) since 2024 |
| Impact for its field and year | 4 / 6 | Cited 16.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 3 / 4 | Cited 67 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Cynthia Ann Lemere: h-index 67 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38255891) |
| Free to read | 2 / 2 | Free to read |
| Total | 51 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.3390/ijms25020817
- PubMed: 38255891
- Original source →
- Free full text: International Journal of Molecular Sciences →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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