Newest studies

Functional connectivity changes in neurodegenerative biomarker-positive athletes with repeated concussions

50/100 ✓ Peer-reviewed Brain scans and imaging Journal of neurology

Key finding: Our study aims to investigate whether biomarker evidence of neurodegeneration in former professional athletes with repetitive concussions (ExPro) is associated with worse cognition and mood/behavior, brain atrophy, and altered functional connectivity. +2 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Automatic offline-capable smartphone paper-based microfluidic device for efficient biomarker detection of Alzheimer's disease

43/100 ✓ Peer-reviewed Cognitive tests and assessment Analytica chimica acta

Key finding: This paper introduces a new deep learning-assisted offline smartphone platform for early AD screening, offering rapid disease detection in low-resource areas. +4 more findings

• Digital Tools
• Biomarkers

Full summary, score breakdown and related studies → Original source

Ageing-Related Neurodegeneration and Cognitive Decline

54/100 ✓ Peer-reviewed Brain tissue and pathology International journal of molecular sciences

Key finding: Overall, hyperphosphorylated (HP) τ was observed in the brains of 98% of the 1610 subjects, and amyloid β-protein (Aβ) in the brains of 64%. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Mitochondrial dysfunction in chronic neuroinflammatory diseases (Review)

43/100 ✓ Peer-reviewed Inflammation and the immune system International journal of molecular medicine

Key finding: Therefore, investigating mechanisms related to mitochondrial dysfunction may result in therapeutic strategies against chronic neuroinflammation and neurodegeneration.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Interpreting artificial intelligence models: a systematic review on the application of LIME and SHAP in Alzheimer's disease detection

72/100 ✓ Peer-reviewed Digital health tools Brain informatics

Key finding: The results emphasise XAI's crucial role in strengthening the trustworthiness of AI-based AD predictions.

• Digital Tools

Full summary, score breakdown and related studies → Original source

Review on anti-alzheimer drug development: approaches, challenges and perspectives

45/100 ✓ Peer-reviewed Drug development RSC advances

Key finding: There is no concrete evidence to identify the exact reason behind the disease, so several relevant hypotheses emerged, highlighting many possible therapeutic targets, such as acetylcholinesterase, cholinergic receptors, N -methyl d-aspartate receptors, phosphodiesterase, amyloid β protein, protein phosphatase 2A, glycogen synthase kinase-3 beta, β-secretase, γ-secretase, α-secretase, serotonergic receptors, glutaminyl cyclase, tumor necrosis factor-α, γ-aminobutyric acid receptors, and mitochondria. +3 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Human iPSC 4R tauopathy model uncovers modifiers of tau propagation

54/100 ✓ Peer-reviewed Laboratory science Cell

Key finding: A CRISPRi screen of genes associated with Tau pathobiology identified over 500 genetic modifiers of seeding-induced Tau propagation, including retromer VPS29 and genes in the UFMylation cascade.

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Metformin in elderly type 2 diabetes mellitus: dose-dependent dementia risk reduction

46/100 ✓ Peer-reviewed Drug development Brain : a journal of neurology

Key finding: Our analysis revealed a significant reduction in the risk of dementia among elderly individuals using metformin, with an adjusted hazard ratio of 0.34 (95% confidence interval: 0.33 to 0.36). +3 more findings

• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Plasma oxysterols are associated with serum lipids and dementia risk in older women

46/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Levels of 24(S)-hydroxycholesterol (24-OHC), 27-hydroxycholesterol (27-OHC), and 24-OHC/27-OHC ratio did not differ by APOE status (p's > 0.05). +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Cognitive and neuroscientific perspectives of healthy ageing

41/100 ✓ Peer-reviewed Prevention trials Neuroscience and biobehavioral reviews

Key finding: With dementia incidence projected to escalate significantly within the next 25 years, the United Nations declared 2021-2030 the Decade of Healthy Ageing, emphasising cognition as a crucial element. +1 more finding

Full summary, score breakdown and related studies → Original source

Do end-of-life outcomes differ by assisted living memory-care designation?

63/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society

Key finding: The unadjusted mortality rates were 13.4% in general RC/AL and 15.8% in memory-care RC/AL with an adjusted difference of 1.3 percentage points higher mortality among memory-care RC/AL residents (p = 0.04). +4 more findings

• Care Services
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Evaluating p-tau217 and p-tau231 as Biomarkers for Early Diagnosis and Differentiation of Alzheimer's Disease: A Narrative Review

43/100 ✓ Peer-reviewed Biomarkers Biomedicines

Key finding: This narrative review is devoted to a critical evaluation of the diagnostic accuracy, sensitivity, and specificity of p-tau217 and p-tau231 levels in the detection of AD, measured in plasma, serum, and cerebrospinal fluid, compared to established biomarkers. +1 more finding

• Biomarkers
• Diagnosis
• Brain Biology

Full summary, score breakdown and related studies → Original source

The efficacy and safety of lecanemab 10 mg/kg biweekly compared to a placebo in patients with Alzheimer's disease: a systematic review and meta-analysis of randomized controlled trials

72/100 ✓ Peer-reviewed Treatments Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Key finding: Alzheimer's disease, prevalent in individuals aged 60 and above, constitutes most dementia cases and significantly impairs memory and cognitive functions. +4 more findings

• Treatments
• Clinical Trials
• Side Effects

Full summary, score breakdown and related studies → Original source

Results from the long-term extension of PRIME: A randomized Phase 1b trial of aducanumab

83/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: The safety profile of aducanumab remained unchanged in the LTE of PRIME. +3 more findings

• Clinical Trials
• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

The time course of motor and cognitive decline in older adults and their associations with brain pathologies: a multicohort study

64/100 ✓ Peer-reviewed Disparities The lancet. Healthy longevity

Key finding: The combinations of pathologies of Alzheimer's disease and related dementias associated with cognitive and motor decline and their onsets of associations varied; only tau tangles, Parkinson's disease pathology, and macroinfarcts were associated with decline of all three phenotypes. +4 more findings

Full summary, score breakdown and related studies → Original source

Long-acting exenatide does not prevent cognitive decline in mild cognitive impairment: a proof-of-concept clinical trial

79/100 ✓ Peer-reviewed Drug development Journal of endocrinological investigation

Key finding: No significant between-group effects of exenatide on ADAS-Cog11 score (p = 0.17) were detected. +4 more findings

• Clinical Trials
• Early Stage

Full summary, score breakdown and related studies → Original source

Neuron-level explainable AI for Alzheimer's Disease assessment from fundus images

59/100 ✓ Peer-reviewed Brain scans and imaging Scientific reports

Key finding: Leveraged UK Biobank cognitive tests and vascular morphological features demonstrate significant promise and effectiveness of LAVA in identifying AD stages across the progression continuum.

• Digital Tools
• Brain Biology

Full summary, score breakdown and related studies → Original source

Serious Mental Illness in Assisted Living Communities: Association with Nursing Home Placement

75/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Medical Directors Association

Key finding: More than half (55.65%) of AL residents had a diagnosis of SMI, among them 93.2% had major depression, 28.5% schizophrenia, and 22.2% bipolar disorder. +3 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

Role of autophagy and proteostasis in neurodegenerative diseases: Exploring the therapeutic interventions

43/100 ✓ Peer-reviewed Disease mechanisms Chemical biology & drug design

Key finding: The common pathological features of these diseases are associated with the accumulation of misfolded or aggregation of proteins. +2 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Hearing loss promotes Alzheimer's disease

46/100 ✓ Peer-reviewed Risk factors Nature aging

Key finding: Epidemiological studies reveal a correlation between hearing loss and the development and progression of Alzheimer’s disease (AD), but the underlying causal mechanisms remain unclear. +1 more finding

• Risk Factors

Full summary, score breakdown and related studies → Original source

Genetic and epigenetic targets of natural dietary compounds as anti-Alzheimer's agents

43/100 ✓ Peer-reviewed Risk genes beyond APOE Neural regeneration research

Key finding: Importantly, the fundamental pathophysiological mechanisms driving Alzheimer's disease are interfaced with epigenetic dysregulation. +4 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Postural Control Characteristics in Alzheimer's Disease, Dementia With Lewy Bodies, and Vascular Dementia

59/100 ✓ Peer-reviewed Cognitive tests and assessment The journals of gerontology. Series A, Biological sciences and medical sciences

Key finding: The study included 1 789 participants (1 206 with AD, 111 with DLB, 49 with VaD, and 423 with NC). +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Montreal Cognitive Assessment (MoCA) XpressO: Validation of a digital self-administered cognitive prescreening tool

52/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of the American Geriatrics Society

Key finding: Analysis showed strong correlation between (1) XpressO memory tasks scores and the MoCA Memory Index Score (p-values < 0.001), and between (2) XpressO sub-test scores and MoCA total score (p-values < 0.005). +4 more findings

• Diagnosis
• Digital Tools

Full summary, score breakdown and related studies → Original source

Quantitative systems pharmacology-based exploration of relevant anti-amyloid therapy challenges in clinical practice

48/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia (New York, N. Y.)

Key finding: This QSP platform could support clinical practice challenges to optimize real-world treatment paradigms for new and existing amyloid drugs. +1 more finding

• Treatments
• Biomarkers

Full summary, score breakdown and related studies → Original source

Reliability and Validity of Smartphone Cognitive Testing for Frontotemporal Lobar Degeneration

76/100 ✓ Peer-reviewed Cognitive tests and assessment JAMA network open

Key finding: The findings of this cohort study suggest that smartphones could offer a feasible, reliable, valid, and scalable solution for remote evaluations of FTLD and may improve early detection. +3 more findings

• Diagnosis
• Digital Tools
• Other Dementias

Full summary, score breakdown and related studies → Original source