Newest studies

Microglial Reactivity Correlates with Presynaptic Loss Independent of β-Amyloid and Tau

57/100 ✓ Peer-reviewed Tau biomarkers Annals of neurology

Key finding: Triggering receptor expressed on myeloid cells-2 (TREM2) and progranulin (PGRN) are critical regulators of microglia activation and can be detected in cerebrospinal fluid (CSF). +3 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Sleep Characteristics and Risk of Stroke and Dementia: An Observational and Mendelian Randomization Study

75/100 ✓ Peer-reviewed Long-term cohort studies Neurology

Key finding: We found that multiple sleep measures predicted future risk of stroke and dementia, but these associations were attenuated after controlling for cardiovascular risk factors and were absent in MR analyses for Alzheimer disease. +3 more findings

• Lifestyle
• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer's and related dementias

43/100 ✓ Peer-reviewed TREM2 and immune genetics EMBO reports

Key finding: Our findings indicate a BRI2-TREM2 interaction that inhibits TREM2 processing in heterologous cells.

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

AI-enabled evaluation of genome-wide association relevance and polygenic risk score prediction in Alzheimer's disease

43/100 ✓ Peer-reviewed Genetics iScience

Key finding: GWAS focuses on significance loosing false positives; machine learning probes sub-significant features relying on predictivity. +2 more findings

• Genetics
• Digital Tools

Full summary, score breakdown and related studies → Original source

Plasma proteomic profiles predict future dementia in healthy adults

65/100 ✓ Peer-reviewed Getting a diagnosis Nature aging

Key finding: Our findings strongly highlight GFAP as an optimal biomarker for dementia prediction, even more than 10 years before the diagnosis, with implications for screening people at high risk for dementia and for early intervention.

• Diagnosis

Full summary, score breakdown and related studies → Original source

The Relationship between p-tau217, p-tau231, and p-tau205 in the Human Brain Is Affected by the Cellular Environment and Alzheimer's Disease Pathology

43/100 ✓ Peer-reviewed Biomarkers Cells

Key finding: The levels of p-tau217 and p-tau231 in cerebrospinal fluid (CSF) are associated with early amyloid beta (Aß) changes in the brain, while the CSF levels of p-tau205 are foremost related to tau pathology in the later stages of the disease. +4 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Characteristics of discordance between amyloid positron emission tomography and plasma amyloid-β 42/40 positivity

54/100 ✓ Peer-reviewed Biomarkers Translational psychiatry

Key finding: PET+/plasma+ was significantly associated with higher tau burden assessed by PET in entorhinal, Braak III/IV, and Braak V/VI regions, and with decreased volume of hippocampal and precuneus regions compared to PET-/plasma-.

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

ApoE Isoforms Inhibit Amyloid Aggregation of Proinflammatory Protein S100A9

43/100 ✓ Peer-reviewed Genetics International journal of molecular sciences

Key finding: Increasing evidence suggests that the calcium-binding and proinflammatory protein S100A9 is an important player in neuroinflammation-mediated Alzheimer's disease (AD). +4 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Post-disclosure distress among racial and ethnic groups in a preclinical AD trial

46/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Reactions to disclosure did not significantly differ among participant groups based on self-reported race and ethnicity. +2 more findings

• Health Equity
• Early Stage

Full summary, score breakdown and related studies → Original source

Exposure to urban particulate matter alters responses of olfactory mucosal cells to SARS-CoV-2 infection

43/100 ✓ Peer-reviewed Risk factors Environmental research

Key finding: Respiratory viruses have a significant impact on health, as highlighted by the COVID-19 pandemic. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Serum amyloid beta 42 levels correlated with metabolic syndrome and its components

50/100 ✓ Peer-reviewed Risk factors Frontiers in endocrinology

Key finding: The results showed that log-transformed serum Aβ42 level was positively correlated with BMI (R = 0.29; p < 0.001), log-transformed triglyceride (R = 0.14; p < 0.001), and diastolic blood pressure (DBP) (R = 0.12; p < 0.001) and negatively correlated with high-density lipoprotein (HDL-c) (R = -0.18; p < 0.001). +4 more findings

Full summary, score breakdown and related studies → Original source

Plasma biomarkers of Alzheimer's disease in the continuum of dementia with Lewy bodies

50/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Abnormal levels of plasma glial fibrillary acidic protein (GFAP) were found at the prodromal stage of MCI-LB in association with increased amyloid PET. +3 more findings

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Artificial intelligence for drug discovery and development in Alzheimer's disease

47/100 ✓ Peer-reviewed Digital health tools Current opinion in structural biology

Key finding: Artificial Intelligence (AI)-guided drug discovery combined with genetics/multi-omics (genomics, epigenomics, transcriptomics, proteomics, and metabolomics) analysis contributes to the understanding of the pathophysiology and precision medicine of the disease, including AD and AD-related dementia. +4 more findings

• Digital Tools
• Treatments

Full summary, score breakdown and related studies → Original source

Cost of care for Alzheimer's disease and related dementias in the United States: 2016 to 2060

48/100 ✓ Peer-reviewed Costs and economics npj Aging

Key finding: 2016 per-patient formal care cost estimated at $28,078; informal care valued at $36,667 (replacement cost) or $15,792 (forgone wages) +3 more findings

• Policy
• Caregiving

Full summary, score breakdown and related studies → Original source

How donanemab data address the coverage with evidence development questions

46/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: TRAILBLAZER-ALZ registration trials demonstrated that donanemab significantly slowed cognitive and functional decline in amyloid-positive early symptomatic AD participants, and lowered their risk of disease progression while key safety risks occurred primarily within the first 6 months and then declined. +1 more finding

• Treatments
• Policy

Full summary, score breakdown and related studies → Original source

Phosphodiesterase Type 5 Inhibitors in Men With Erectile Dysfunction and the Risk of Alzheimer Disease: A Cohort Study

76/100 ✓ Peer-reviewed Treatments Neurology

Key finding: PDE5I initiation in men with ED was associated with a lower risk of AD, particularly in those most frequently issued prescriptions. +4 more findings

• Clinical Trials
• Treatments
• Risk Factors

Full summary, score breakdown and related studies → Original source

Tau accumulation and its spatial progression across the Alzheimer's disease spectrum

65/100 ✓ Peer-reviewed Laboratory science Brain Communications

Key finding: 832 participants, 1,370 tau-PET scans; over 91% of tau-positive participants matched the expected Braak staging order cross-sectionally +3 more findings

Full summary, score breakdown and related studies → Original source

Validity and Reliability Study of Online Cognitive Tracking Software (BEYNEX)

50/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Alzheimer's disease reports

Key finding: Beynex categorization scores showed a moderate agreement with MoCA ratings (weighted Cohen's Kappa = 0.48; 95% CI: 0.38-0.60). +3 more findings

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Considerations for Use of Blood-Based Biomarkers in Epidemiologic Dementia Research

43/100 ✓ Peer-reviewed Biomarkers American journal of epidemiology

Key finding: Although largely not yet approved by the Food and Drug Administration or used in clinical settings, blood-based biomarkers are increasingly included in epidemiologic studies on dementia. +4 more findings

• Biomarkers
• Health Equity

Full summary, score breakdown and related studies → Original source

Exploring Natural Compounds for Alzheimer's Disease: Virtual Screening and Docking Study with KIBRA Protein

16/100 ⚠ Preprint — not yet peer-reviewed Drug development Preprints.org

Key finding: The present theorical work utilized Virtual Screening and Docking techniques to explore potential small natural molecules' interactions with the KIBRA protein, a promising target for drug development. +3 more findings

• Treatments
• Diagnosis

Full summary, score breakdown and related studies → Original source

Artificial Intelligence Assistive Software Tool for Automated Detection and Quantification of Amyloid-Related Imaging Abnormalities

53/100 ✓ Peer-reviewed Drug development JAMA network open

Key finding: ARIA monitoring is important to inform treatment dosing decisions and might be improved through assistive software. +3 more findings

• Treatments
• Brain Scans
• Side Effects

Full summary, score breakdown and related studies → Original source

Investigating White Matter Neuroinflammation in Alzheimer Disease Using Diffusion-Based Neuroinflammation Imaging

59/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: Alzheimer disease (AD) is primarily associated with accumulations of amyloid plaques and tau tangles in gray matter, however, it is now acknowledged that neuroinflammation, particularly in white matter (WM), significantly contributes to the development and progression of AD. +3 more findings

• Brain Biology
• Brain Scans

Full summary, score breakdown and related studies → Original source

Physical Activity and Cognitive Decline Among Older Adults: A Systematic Review and Meta-Analysis

80/100 ✓ Peer-reviewed Prevention and risk JAMA Network Open

Key finding: In this meta-analysis of the association of physical activity with cognitive decline, physical activity was associated with better late-life cognition, but the association was weak. +4 more findings

• Lifestyle

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Tryptanthrin Analogs Substoichiometrically Inhibit Seeded and Unseeded Tau4RD Aggregation

16/100 ⚠ Preprint — not yet peer-reviewed Drug development bioRxiv : the preprint server for biology

Key finding: Despite keen interest in disrupting or inhibiting tau aggregation to treat AD and related dementias, there are currently no FDA-approved tau-targeting drugs. +4 more findings

• Treatments

Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

The Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) Diet for the Aging Brain: A Systematic Review

79/100 ✓ Peer-reviewed Prevention trials Advances in nutrition (Bethesda, Md.)

Key finding: Previous systematic reviews have demonstrated benefits of the MIND diet for cognition and dementia, though an update is needed. +3 more findings

• Lifestyle
• Risk Factors

Full summary, score breakdown and related studies → Original source