Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 8,076–8,100 of 27,380 studies, newest first · page 324 of 1096.
January 2023 25
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2023 year only
Dietary Components and Nutritional Strategies for Dementia Prevention in the Elderly
48/100 ✓ Peer-reviewed Prevention and risk Current Alzheimer research
Key finding: Polyphenols, folate, vitamin D, omega-3 fatty acids, and β-carotene might decrease the risk of dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023 year only
Diet's Role in Modifying Risk of Alzheimer's Disease: History and Present Understanding
48/100 ✓ Peer-reviewed Prevention and risk Journal of Alzheimer's disease : JAD
Key finding: Those studies identified AD risk factors including higher consumption of saturated and total fats, meat, and ultraprocessed foods and a lower risk of AD with higher consumption of fruits, legumes, nuts, omega-3 fatty acids, vegetables, and whole grains. +1 more finding
Full summary, score breakdown and related studies → Original source
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2023 year only
Air Pollution and the Risk of Dementia: The Rotterdam Study
41/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD
Key finding: Of the 7,511 non-demented participants at baseline, 545 developed dementia during a median follow-up of 7 years. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023 year only
Depressive and Biopsychosocial Frailty Phenotypes: Impact on Late-life Cognitive Disorders
41/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD
Key finding: Multidimensional frailty phenotypes have been associated with all-cause dementia, mild cognitive impairment (MCI), Alzheimer's disease (AD), AD neuropathology, vascular dementia, and non-AD dementias.
Full summary, score breakdown and related studies → Original source
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2023 year only
The Early Stage of Abnormal Aging: Cognitive Impairment
41/100 ✓ Peer-reviewed Risk factors Advances in experimental medicine and biology
Key finding: Cognitive impairment has become an important aspect affecting the health and quality of life of middle-aged and elderly people, which is defined as the difficulty of thought processing and leads to memory loss, difficulties making decisions, the inability to concentrate, and difficulties learning. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023 year only
Cardiovascular Risk Management in Persons with Dementia
41/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD
Key finding: However, in this population, beneficial and harmful effects of cardiovascular risk management (CVRM) may be different compared to older persons without cognitive impairment. +2 more findings
Full summary, score breakdown and related studies → Original source
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2023 year only
Association Between Sensory Impairment and Dementia: The Roles of Social Network and Leisure Activity
57/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD
Key finding: Dual impairment, but not single impairment in hearing and vision was associated with a higher risk of dementia (HR: 1.62, 95% CI: 1.16 to 2.27). +2 more findings
Full summary, score breakdown and related studies → Original source
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2023 year only
Understanding the Association Between Sensory Impairment and Dementia: Toward Informing Future Research and Health Policy
41/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD
Key finding: Recent epidemiological research has linked decline in multiple sensory functions with an increased risk of dementia.
Full summary, score breakdown and related studies → Original source
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2023 year only
Insomnia Symptoms and Biomarkers of Alzheimer's Disease in the Community
55/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD
Key finding: Higher ISI score was associated with greater average levels of CSF Aβ42 (per point: 30.7 pg/mL, 95% CI: 4.17-57.3, p = 0.023), as was higher WASO (per 10 min: 136 pg/mL, 95% CI: 48-223, p = 0.002) and more awakenings (per 5:123 pg/mL, 95% CI = 55-192, p < 0.001). +3 more findings
Full summary, score breakdown and related studies → Original source
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2023 year only
Investigating Partially Discordant Results in Phase 3 Studies of Aducanumab
80/100 ✓ Peer-reviewed Clinical trials The journal of prevention of Alzheimer's disease
Key finding: Post-hoc analyses showed that outcomes in the ENGAGE high-dose group were affected by an imbalance in a small number of patients with extremely rapid progression and by lower exposure to the target dose of 10 mg/kg. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023 year only
Protocol of a Phase II Randomized, Multi-Center, Double-Blind, Placebo-Controlled Trial of S-Adenosyl Methionine in Participants with Mild Cognitive Impairment or Dementia Due to Alzheimer's Disease
59/100 ✓ Peer-reviewed Clinical trials The journal of prevention of Alzheimer's disease
Key finding: The primary outcome is change in plasma p-tau181 concentration between baseline and following 180 days of treatment, which will be compared between the active and placebo group. +2 more findings
Full summary, score breakdown and related studies → Original source
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2023 year only
Lecanemab Clarity AD: Quality-of-Life Results from a Randomized, Double-Blind Phase 3 Trial in Early Alzheimer's Disease
75/100 ✓ Peer-reviewed Clinical trials The journal of prevention of Alzheimer's disease
Key finding: A total of 1795 participants were enrolled (lecanemab:898; placebo:897). +4 more findings
Full summary, score breakdown and related studies → Original source
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2023 year only
Foresee Novel Targets for Alzheimer's Disease by Investigating Repurposed Drugs
41/100 ✓ Peer-reviewed Drug development CNS & neurological disorders drug targets
Key finding: Drugs like Zileuton, Salbutamol, Baricitinib, Carmustine, Paclitaxel, and Nilotinib were observed to be involved in regulation of neurotransmitters. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023 year only
The Late Stage of Abnormal Aging: Dementia
41/100 ✓ Peer-reviewed Drug development Advances in experimental medicine and biology
Key finding: Dementia does not only posing a serious threat to basic daily living in old age but also impose a greater burden on social and medical care as well as the economy. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023 year only
Passive tau-based immunotherapy for tauopathies
41/100 ✓ Peer-reviewed Drug development Handbook of clinical neurology
Key finding: At present, 12 anti-tau antibodies have entered clinical trials, and 7 of them are still in clinical testing for primary tauopathies and AD (semorinemab, bepranemab, E2814, JNJ-63733657, Lu AF87908, PNT00, and APNmAb005). +4 more findings
Full summary, score breakdown and related studies → Original source
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2023 year only
Viewpoint: Clinicians' Perspectives on How Disease Modifying Drugs for Alzheimer's Disease Impact Specialty Care
41/100 ✓ Peer-reviewed Treatments The journal of prevention of Alzheimer's disease
Key finding: In the mid term, the availability of oral anti-amyloid therapy, likely with lower risk of ARIA, may transform clinical practice to a model of screening suitable patients using plasma biomarkers, with a subsequent rapid referral to a specialized memory clinic.
Full summary, score breakdown and related studies → Original source
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2023 year only
The Anti-Amyloid Monoclonal Antibody Lecanemab: 16 Cautionary Notes
41/100 ✓ Peer-reviewed Treatments Journal of Alzheimer's disease : JAD
Key finding: After the CLARITY-AD clinical trial results of lecanemab were interpreted as positive, and supporting the amyloid hypothesis, the drug received accelerated Food and Drug Administration approval. +1 more finding
Full summary, score breakdown and related studies → Original source
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2023 year only
Neuropathology of Anti-Amyloid-β Immunotherapy: A Case Report
46/100 ✓ Peer-reviewed Treatments Journal of Alzheimer's disease : JAD
Key finding: Neuropathological examination demonstrated histiocytic vasculitis involving blood vessels with cerebral amyloid angiopathy. +1 more finding
Full summary, score breakdown and related studies → Original source
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2023 year only
Novel anti-amyloid-beta (Aβ) monoclonal antibody lecanemab for Alzheimer's disease: A systematic review
80/100 ✓ Peer-reviewed Treatments International journal of immunopathology and pharmacology
Key finding: The FDA approved lecanemab for Alzheimer's disease in January 2023 which acts as a novel disease-modifying anti-amyloid-beta (Aβ) human monoclonal antibody and is administered intravenously. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023 year only
Deep Reinforcement Learning-Based Retinal Imaging in Alzheimer's Disease: Potential and Perspectives
41/100 ✓ Peer-reviewed Brain scans and imaging Journal of Alzheimer's disease : JAD
Key finding: Current retinal imaging demonstrates immense potential as a non-invasive screening measure for AD, by studying qualitative and quantitative changes in the neuronal and vascular structures of the retina that are often associated with degenerative changes in the brain.
Full summary, score breakdown and related studies → Original source
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2023 year only
Preclinical Brain Network Abnormalities in Patients with Subjective Cognitive Decline
41/100 ✓ Peer-reviewed Brain scans and imaging Journal of Alzheimer's disease : JAD
Key finding: No between-group differences in grey matter volumes were detected. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023 year only
Chinese Preclinical Alzheimer's Disease Study (C-PAS): Design and Challenge from PET Acceptance
71/100 ✓ Peer-reviewed Brain scans and imaging The journal of prevention of Alzheimer's disease
Key finding: There were 571 participants in the normal cognition group, 625 participants in the subjective cognitive decline group, 155 participants in the objectively defined subtle cognitive decline group, 501 participants in the mild cognitive impairment group, 471 participants in Alzheimer's disease group, and 128 participants with cognitive impairment from other known causes. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023 year only
Hybrid PET/MRI with Flutemetamol and FDG in Alzheimer's Disease Clinical Continuum
41/100 ✓ Peer-reviewed Brain scans and imaging Current Alzheimer research
Key finding: High Aβ deposition (increased temporal [18F]-Flutemetamol standardized uptake value ratio (SUVr) and centiloid score), low glucose metabolism (decreased temporal lobe and posterior cingulate [18F]-FDG SUVr), low parietal CBF and right hemispheric cortical thickness were independent predictors of low cognitive test performance. +1 more finding
Full summary, score breakdown and related studies → Original source
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2023 year only
Weight Loss and Alzheimer's Disease in Down Syndrome
52/100 ✓ Peer-reviewed Brain scans and imaging Journal of Alzheimer's disease : JAD
Key finding: Polynomial regressions indicated an 0.23 kg/m2 decrease in BMI per year beginning at age 36.5 years, which occurs alongside the period during which Aβ and tau increase and memory and mental status decline. +2 more findings
Full summary, score breakdown and related studies → Original source
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2023 year only
[Early-onset familial Alzheimer's disease with spastic paraparesis associated with PSEN1 gene]
46/100 ✓ Peer-reviewed Risk genes beyond APOE Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
Key finding: In the son examined in 2022 at 27 years old whole-exome sequencing detected a novel PSEN1 missense mutation p.Thr421Ala. +4 more findings
Full summary, score breakdown and related studies → Original source
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