Newest studies

Alzheimer's Disease Detection via Large Pre-Trained Speech and Language Models: Taxonomy, Progress, and Open Challenges

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools PsyArXiv

Key finding: These models often report higher performance on shared AD detection benchmarks than handcrafted-feature pipelines, while reducing the need for manual feature design. +4 more findings

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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The Complex Dynamics of Caregiving for ADRD Patients in Uganda: Selection Factors, Challenges, and Benefits

16/100 ⚠ Preprint — not yet peer-reviewed Caregiving Research Square

Key finding: Three interrelated themes emerged: relational foundations of caregiving, multidimensional struggles of caregiving, and benefits of caregiving. +4 more findings

• Caregiving

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Postmortem Alterations of Metabotropic Glutamate Receptors across Neuropsychiatric Disorders: A Systematic Review

16/100 ⚠ Preprint — not yet peer-reviewed Prevention and risk bioRxiv

Key finding: We aimed to map these findings across diagnoses, receptor subtypes, brain regions, and measurement modalities.

• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Structural optimization of coumarin-pyridine hybrid derivative salts as potent acetylcholinesterase inhibitors

16/100 ⚠ Preprint — not yet peer-reviewed Treatments Research Square

Key finding: Our findings highlight the great potential of coumarin- and isocoumarin-pyridine hybrid derivative salts as AChE inhibitors.

• Treatments

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Health-related factors and their impact on blood-based biomarkers of Alzheimer's disease

57/100 ✓ Peer-reviewed Biomarkers Aging brain

Key finding: The study included CSF-characterized individuals with AD (mild cognitive impairment due to AD and AD dementia) and cognitively healthy controls (n = 116; mean age 71.2 years). +4 more findings

• Biomarkers
• Genetics

Full summary, score breakdown and related studies → Original source

Causal roles of phenotypic age and metabolic health on dementia: a Mendelian randomisation and structure learning study

16/100 ⚠ Preprint — not yet peer-reviewed Genetics medRxiv (preprint)

Key finding: BackgroundPhenotypic age acceleration (PhenoAgeAccel), derived from PhenoAge, and MetaboHealth are composite exposures of biological ageing and metabolic health associated with dementia-related outcomes. +3 more findings

• Genetics

Scored 36 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Proteoform-resolved neoGFAP as a diagnostic and prognostic biomarker across the TBI--MCI--AD continuum in Veterans

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv (preprint)

Key finding: Service members with traumatic brain injury are at approximately two- to four-fold higher risk of Alzheimers disease or related dementias than those without such an injury, with risk increasing with injury severity. +4 more findings

• Biomarkers
• Early Stage
• Diagnosis

Scored 33 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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External Validation of a Mathematical Model of Brain Health

16/100 ⚠ Preprint — not yet peer-reviewed Genetics medRxiv (preprint)

Key finding: MethodsThe model represents the evolution of key biological processes associated with brain aging, including amyloid beta (A{beta}), tau pathologies, neuroinflammation, and neuronal death. +2 more findings

• Brain Biology

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Dopaminergic therapy selectively amplifies hallucination susceptibility in patients with Parkinson's disease with cortico-striatal hyperconnectivity

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging medRxiv (preprint)

Key finding: Rather than supporting a uniform hallucinogenic effect of dopamine in PD, these findings indicate that DRT interacts with an intrinsic neural vulnerability that varies in patients.

• Treatments
• Other Dementias

Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Evaluating Clinical Foundation Models for Early Alzheimer's Disease and Related Dementia Prediction from Longitudinal EHRs

16/100 ⚠ Preprint — not yet peer-reviewed How common it is medRxiv (preprint)

Key finding: Predictive performance declined with increasing lead time for all approaches; however, the performance gap between count-based and pretrained representations progressively narrowed, with foundation models achieving comparable AUROC of 0.719 (compared to the AUROC of 0.738 of count-based model) at the 36-month horizon while providing higher sensitivity and F1 scores under a fixed operating threshold. +1 more finding

Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Differential associations of individual- and neighborhood-level socioeconomic status with mortality in dementia: Findings from the Mayo Clinic Study of Aging

43/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer s Disease

Key finding: Lower SES measured by HOUSES was associated with increased mortality risk (HR 1.28, 95% CI 1.07-1.52). +3 more findings

• Risk Factors
• Health Equity

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Geospatial analysis of the association of cardiometabolic diseases and incident Lewy body dementia in the Medicare population

58/100 ✓ Peer-reviewed Risk factors npj Parkinson s Disease

Key finding: Stroke is associated with a higher LBD risk. +4 more findings

• Risk Factors
• Other Dementias
• Policy

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Evaluation of Disease Severity Using CSF Biomarkers in Patients With Probable Cerebral Amyloid Angiopathy

50/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: Cerebral amyloid angiopathy (CAA) is currently diagnosed using MRI-based Boston criteria. +3 more findings

• Biomarkers

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Clinical Phenotype of Apoe Ɛ4 Carriers In Patients With Vascular Dementia: A Cross-Sectional Study From Indonesia

52/100 ✓ Peer-reviewed Lewy body dementia F1000Res

Key finding: This study demonstrated that APOE4 carrier status was associated with lower MoCA-INA scores in this small VaD cohort. +4 more findings

• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

A Study on the Association Between the Course of Heart Failure and Cognitive Function in Older Adults: Based on Data from the 2011–2014 National Health and Nutrition Examination Survey

16/100 ⚠ Preprint — not yet peer-reviewed Prevention and risk Research Square

Key finding: The 2,885 participants had a mean age of 69.5 years. +3 more findings

• Prevention
• Risk Factors

Scored 50 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Insomnia symptoms, daytime sleepiness, and quality of life in people with Alzheimer’s disease: a secondary cross-sectional analysis

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors Research Square

Key finding: Participants were aged 60–94 years, with a mean age of 78.5 ± 7.9 years, and 45.7% were women. +4 more findings

• Lifestyle

Scored 40 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Left ventricular hypertrophy, brain atrophy and cognitive decline in type 2 diabetes mellitus: Diabetes & Dementia (D2) cohort study

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging medRxiv (preprint)

Key finding: BACKGROUNDPeople with type 2 diabetes mellitus (T2DM) are at higher risk of cerebral small vessel disease and left ventricular hypertrophy (LVH), potentially contributing to cognitive decline and dementia. +4 more findings

• Brain Scans
• Risk Factors

Scored 38 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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ECG-based longitudinal risk prediction across diseases and organ systems

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools medRxiv (preprint)

Key finding: These findings support the feasibility of ECG-based longitudinal risk prediction across multiple diseases.

Scored 28 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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A Two-Stage Plasma Biomarker Algorithm Reduces Amyloid PET Use and the p-Tau217 Gray Zone

44/100 ✓ Peer-reviewed Biomarkers Annals of clinical and translational neurology

Key finding: Overall, 89.0% of ADNI and 90.7% of A4/LEARN participants were classified without PET; modeled testing costs were 44-52% lower than p-Tau217 screening with PET confirmation of the gray zone.

• Biomarkers
• Brain Scans

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Analytical validation and amyloid-status discrimination of a high-throughput, research-use-only plasma p-Tau217 immunoassay

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv (preprint)

Key finding: ResultsThe assay demonstrated high precision (within-laboratory CV [≤]7.1%), excellent sensitivity (limit of detection 0.018-0.021 pg/mL), linearity across the analytical measuring range (R{superscript 2} > 0.99), strong epitope specificity ([≤]1.0% cross-reactivity with other tau phosphoisofo

• Biomarkers

Scored 33 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Real-World Challenges in the MRI Detection and Classification of Amyloid-Related Imaging Abnormalities

44/100 ✓ Peer-reviewed Treatments American Journal of Roentgenology

Key finding: In routine clinical practice, MRI findings encountered during baseline screening and ARIA surveillance sometimes fall into borderline or ambiguous categories that do not clearly conform to trial-defined criteria. +4 more findings

• Brain Scans
• Treatments
• Side Effects

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Elucidating shared genetic signals between type 2 diabetes and three neurodegenerative dementia phenotypes

36/100 ✓ Peer-reviewed Genetics Human Genetics and Genomics Advances

Key finding: Our findings identify shared genetic loci between T2D and neurodegenerative dementia, revealing systemic metabolic-neurodegenerative trade-offs and highlighting key genes that underpin the comorbidity, providing a framework for improved understanding of age-related multi-morbidity.

• Genetics
• Risk Factors

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Exploratory factor and network analysis of 43 inflammatory plasma biomarkers and cognitive performance in Black adults

44/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer s Disease

Key finding: Two factors were significantly associated with cognitive performance after FDR correction. +3 more findings

• Biomarkers
• Brain Biology
• Health Equity

Full summary, score breakdown and related studies → Original source

P-TAU217 COMO BIOMARCADOR SANGUÍNEO NO DIAGNÓSTICO PRECOCE DA DOENÇA DE ALZHEIMER: UMA REVISÃO DA LITERATURA

36/100 ✓ Peer-reviewed Biomarkers Revista Ibero-Americana de Humanidades, Ciências e Educação

Key finding: Nesse contexto, esse artigo buscou avaliar a utilização da proteína tau fosforilada na treonina 217 (p-tau217) como biomarcador sanguíneo na identificação precoce da DA, considerando sua relação com as alterações neuropatológicas e suas possíveis aplicações diagnósticas. +4 more findings

• Biomarkers

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Five Decades of Infusion Testing in Idiopathic Normal Pressure Hydrocephalus: A Biomarker in Search of a Gold Standard

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools Preprints.org

Key finding: Recalculation of likelihood ratios from published meta-analyses demonstrates that none of the commonly proposed Rout thresholds (10-18 mmHg·min/mL) achieves the prognostic performance typically associated with a strong rule-in or rule-out test. +1 more finding

• Biomarkers

Scored 47 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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