Newest studies

Plasma markers of neurodegeneration, latent cognitive abilities and physical activity in healthy aging

50/100 ✓ Peer-reviewed Biomarkers Scientific reports

Key finding: The results showed that NfL was negatively associated with working memory, and that NfL interacted with moderate-to-vigorous physical activity in its association with episodic memory. +1 more finding

• Biomarkers
• Lifestyle

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Brain insulin resistance in Down syndrome: Involvement of PI3K-Akt/mTOR axis in early-onset of Alzheimer's disease and its potential as a therapeutic target

35/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Biochemical and biophysical research communications

Key finding: Both domains contribute to the intricate mechanism underlying this dysregulation. +4 more findings

• Down Syndrome
• Brain Biology

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Paying for advance care planning in medicare: Impacts on care and spending near end of life

38/100 ✓ Peer-reviewed Health systems and care delivery Journal of health economics

Key finding: Among decedents, death is significantly less likely to occur in the hospital, and total and inpatient spending within the last 30 days of life fall significantly. +1 more finding

• End-of-Life Care
• Policy

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AI-driven innovations in Alzheimer's disease: Integrating early diagnosis, personalized treatment, and prognostic modelling

56/100 ✓ Peer-reviewed Digital health tools Ageing research reviews

Key finding: Alzheimer's disease (AD) presents a significant challenge in neurodegenerative research and clinical practice due to its complex etiology and progressive nature.

• Digital Tools
• Treatments
• Diagnosis

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PM2.5 is linked to Alzheimer's syndrome and delirium: a mendelian randomization analysis

43/100 ✓ Peer-reviewed Risk factors International journal of clinical and experimental pathology

Key finding: The odds ratio (OR) for Alzheimer's disease was 0.996 with a p-value of 0.443 using the inverse variance weighted algorithm, and the OR associated with the outcome variable of delirium was 0.393 with a p-value of 0.343. +2 more findings

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Resting-state functional connectivity abnormalities in subjective cognitive decline: A 7T MRI study

43/100 ✓ Peer-reviewed Brain scans and imaging Neurobiology of aging

Key finding: Compared to the other two groups, SCD showed higher FC in frontal default mode network (DMN) and insular and superior temporal nodes of ventral attention network (VAN). +1 more finding

• Brain Scans
• Early Stage

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Epigenetic age acceleration and cognitive performance over time in older adults

50/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Associations between epigenetic AA and cognitive performance over-time varied by sex. +4 more findings

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The influences of ApoE isoforms on endothelial adherens junctions and actin cytoskeleton responding to mCRP

43/100 ✓ Peer-reviewed Genetics Angiogenesis

Key finding: Using phosphor-proteomic profiling, we found altered cytoskeleton proteins in the microvasculature of AD brains, including increased levels of hyperphosphorylated tau (pTau) and the actin-related protein, LIMA1. +2 more findings

• Genetics

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Lewy body pathology exacerbates brain hypometabolism and cognitive decline in Alzheimer's disease

69/100 ✓ Peer-reviewed Laboratory science Nature Communications

Key finding: The AD+LB+ group showed worst baseline performance for most cognitive outcomes and compared to the AD+LB- group faster global cognitive decline and more cortical hypometabolism, particularly in posterior brain regions. +1 more finding

• Other Dementias

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Production of Terpene Trilactones from Cell and Organ Cultures of Ginkgo biloba

36/100 ✓ Peer-reviewed Risk factors Plants

Key finding: In addition, the accumulation of TTLs in these plants is affected by age, sex, and seasonal and geographical variations. +4 more findings

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Association of Resilience-Related Life Experiences on Variability on Age of Onset in Dominantly Inherited Alzheimer Disease

56/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: It remains unknown whether the associations between protective lifestyles and sporadic dementia risk reported in observational studies also affect age at symptom onset (AAO) in autosomal dominant Alzheimer disease (ADAD) with predominant genetic influences. +3 more findings

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Core CSF Biomarker Profile in Cerebral Amyloid Angiopathy: Updated Meta-Analysis

69/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: There is a clear need to characterize and validate molecular biomarkers of cerebral amyloid angiopathy (CAA), in an effort to improve diagnostics, especially in the context of patients with Alzheimer disease (AD) receiving immunotherapies (for whom underlying CAA is the driver of amyloid-related imaging abnormalities). +3 more findings

• Biomarkers

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Combining cerebrospinal fluid and PI-2620 tau-PET for biomarker-based stratification of Alzheimer's disease and 4R-tauopathies

54/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Elevated CSF p-tau181 and cortical 18F-PI-2620 binding was characteristic for AD while normal CSF p-tau181 with elevated subcortical 18F-PI-2620 binding was characteristic for 4RTs. 18F-PI-2620-assessed posterior cortical hypoperfusion could be used as an additional neuronal injury biomarker in AD. +4 more findings

• Biomarkers
• Brain Scans

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Association of white matter hyperintensities with cognitive decline and neurodegeneration

70/100 ✓ Peer-reviewed Tau biomarkers Frontiers in aging neuroscience

Key finding: Higher WMH volume was associated with older age, lower CSF amyloid-β levels, hypertension, and smoking history (all p ≤ 0.001), as well as cognitive status (MCI, p < 0.001; dementia, p = 0.008), but not with CSF tau levels. +4 more findings

• Risk Factors

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Amyloid-β Causes NMDA Receptor Dysfunction and Dendritic Spine Loss through mGluR1 and AKAP150-Anchored Calcineurin Signaling

43/100 ✓ Peer-reviewed Disease mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: By employing AKAP150 knock-in mice of both sexes with a mutation that disrupts CaN anchoring to AKAP150, we revealed that local, postsynaptic AKAP-CaN-LTD signaling was required for Aβ-mediated impairment of NMDAR synaptic Ca2+ influx, inhibition of LTP, and dendritic spine loss. +2 more findings

• Brain Biology

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Associations between misfolded alpha-synuclein aggregates and Alzheimer's disease pathology in vivo

68/100 ✓ Peer-reviewed Brain tissue and pathology Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Across cohorts, the main biomarker associated with α-synuclein positivity at baseline was higher levels of Aβ pathology (all p values ≤ 0.02), but not tau. +4 more findings

• Brain Biology

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Predicting CDR status over 36 months with a recall-based digital cognitive biomarker

55/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: The best predictor of CDR at 36 months was M, a DCB reflecting recall ability (area under the curve = 0.84), outperforming traditional scores. +4 more findings

• Diagnosis
• Biomarkers
• Digital Tools

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Effects of Virtual Reality Motor-Cognitive Training for Older People With Cognitive Frailty: Multicentered Randomized Controlled Trial

80/100 ✓ Peer-reviewed Prevention trials Journal of medical Internet research

Key finding: The effects were not statistically significant on other outcomes. +1 more finding

• Clinical Trials

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Can cerebrospinal fluid biomarkers tell us something about financial capacity in Alzheimer's disease patients? A preliminary study

31/100 ✓ Peer-reviewed Tau biomarkers Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater

Key finding: Although diagnostic markers in cerebrospinal fluid (CSF) have become a rapidly growing research field, they have not as yet been investigated in relation to capacities that are of interest to geriatric psychiatry and neuropsychology, such as financial capacity. +3 more findings

• Biomarkers
• Diagnosis

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Factors associated with cognitive reserve according to education level

57/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: In the low-education group, low literacy, long sleep duration(>8 h/day), and diabetes were negatively associated with CR, whereas cognitive and physical activity were positively associated with CR. +4 more findings

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Alzheimer's disease-related presenilins are key to intestinal epithelial cell function and gut immune homoeostasis

43/100 ✓ Peer-reviewed Risk genes beyond APOE Gut

Key finding: Psen1 expression was regulated in experimental gut inflammation and in patients with IBD. +4 more findings

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Mitigation of synaptic and memory impairments via F-actin stabilization in Alzheimer's disease

43/100 ✓ Peer-reviewed Disease mechanisms Alzheimer's research & therapy

Key finding: We found a significant reduction in PSD-95-actin association in synaptosomes from middle-aged APP/PS1 mice compared to wild-type (WT) mice. +4 more findings

• Brain Biology

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Multi-omics analysis of gut-brain axis reveals novel microbial and neurotransmitter signatures in patients with arteriosclerotic cerebral small vessel disease

43/100 ✓ Peer-reviewed Disease mechanisms Pharmacological research

Key finding: Although its underlying pathogenesis remains poorly understood, both inflammaging and gut microbiota dysbiosis have been hypothesized to play significant roles. +4 more findings

• Other Dementias

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A Systematic Review of Antidepressants and Psychotherapy Commonly Used in the Treatment of Late Life Depression for Their Effects on Cognition

71/100 ✓ Peer-reviewed Risk factors The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: Sertraline and vortioxetine had significant positive effects on processing speed and memory. +2 more findings

• Treatments

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Cognitive modeling of the Mnemonic Similarity Task as a digital biomarker for Alzheimer's disease

57/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: A MPT model of the MST can detect individuals with AD prior to cognitive decline, making it a potentially useful tool for screening and monitoring older adults during the asymptomatic phase of AD.

• Biomarkers
• Digital Tools

Full summary, score breakdown and related studies → Original source