Newest studies

Long-Term Intake of Red Meat in Relation to Dementia Risk and Cognitive Function in US Adults

66/100 ✓ Peer-reviewed Prevention and risk Neurology

Key finding: Replacing 1 serving per day of nuts and legumes for processed red meat was associated with a 19% lower risk of dementia (HR 0.81, 95% CI 0.75-0.86), 1.37 fewer years of cognitive aging (95% CI -2.49 to -0.25), and a 21% lower risk of SCD (RR 0.79, 95% CI 0.68-0.92). +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Estimating the burden of underdiagnosis within England: A modelling study of linked primary care data

42/100 ✓ Peer-reviewed Risk factors PLoS ONE

Key finding: Levels of underdiagnosis varied between 16% for stroke and 69% for prostate cancer in 2018. +4 more findings

Full summary, score breakdown and related studies → Original source

Clinical utility of plasma p-tau217 in identifying abnormal brain amyloid burden in an Asian cohort with high prevalence of concomitant cerebrovascular disease

66/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Risk stratification for PET Aβ+ based on a plasma p-tau217 assay demonstrated potential diagnostic and prognostic utility in an Asian cohort with concomitant CeVD. +3 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Cutting through the noise: A narrative review of Alzheimer's disease plasma biomarkers for routine clinical use

45/100 ✓ Peer-reviewed Biomarkers The journal of prevention of Alzheimer's disease

Key finding: Despite the high performance and robustness demonstrated in research, plasma p-tau217, like all plasma biomarkers, can be affected by analytical and pre-analytical variability as well as patient comorbidities, sex, ethnicity, and race.

• Biomarkers
• Treatments

Full summary, score breakdown and related studies → Original source

Dementia Diagnosis Unawareness and Caregiver Burden in a Multi-ethnic Cohort

70/100 ✓ Peer-reviewed Caregiving Journal of general internal medicine

Key finding: Eighty-one percent of eligible participants were not aware of a dementia diagnosis. +4 more findings

• Caregiving
• Diagnosis
• Health Equity

Full summary, score breakdown and related studies → Original source

Clinical criteria for limbic-predominant age-related TDP-43 encephalopathy

68/100 ✓ Peer-reviewed Brain tissue and pathology Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Alternatively, when present with ADNC, LATE-NC is associated with a more rapid course.

• Brain Biology

Full summary, score breakdown and related studies → Original source

The immunology of stroke and dementia

43/100 ✓ Peer-reviewed Treatments Immunity

Key finding: Ischemic stroke and vascular cognitive impairment, caused by a sudden arterial occlusion or more subtle but protracted vascular insufficiency, respectively, are leading causes of morbidity and mortality worldwide with limited therapeutic options. +3 more findings

Full summary, score breakdown and related studies → Original source

Brain-derived tau oligomer polymorphs: distinct aggregations, stability profiles, and biological activities

45/100 ✓ Peer-reviewed Disease mechanisms Communications Biology

Key finding: Our results indicate that the aBDTOs possess different structural and morphological features that impact neuronal function, gene regulation, and ultimately disease progression. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

The association of seizure control with neuropathology in dementia

52/100 ✓ Peer-reviewed Long-term cohort studies Brain

Key finding: Seizures in people with dementia (PWD) are associated with faster cognitive decline and worse clinical outcomes. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Assessment of Cognitive Functions in Multimorbid Patients in Lithuanian Primary Care Settings: A Cross-Sectional Study Using MMSE and LT-GPCOG

44/100 ✓ Peer-reviewed Cognitive tests and assessment Medicina

Key finding: Out of 796 participants, 793 completed the study. +4 more findings

• Diagnosis
• Care Services

Full summary, score breakdown and related studies → Original source

Avanços em biomarcadores plasmáticos e do líquido cefalorraquidiano para a detecção precoce da doença de Alzheimer

27/100 ✓ Peer-reviewed Tau biomarkers Brazilian Journal of Health Review

Key finding: A pesquisa destacou a importância de biomarcadores como p-tau e β-amiloide no diagnóstico precoce e acompanhamento da Doença de Alzheimer (DA). +4 more findings

Full summary, score breakdown and related studies → Original source

Modifiable risk factors for early- and late-onset dementia using the Korean national health insurance service database

42/100 ✓ Peer-reviewed Risk factors The Journal of Prevention of Alzheimer s Disease

Key finding: Higher socioeconomic status and increased frequency of physical activity were associated with a lower risk of both EOD and LOD. +4 more findings

• Risk Factors
• Prevention
• Lifestyle

Full summary, score breakdown and related studies → Original source

Cardiometabolic Multimorbidity and Dementia Onset Among Middle-Aged and Older Adults: Differences by Race/Ethnicity

53/100 ✓ Peer-reviewed Disparities The Journals of Gerontology Series A

Key finding: Over a mean follow-up of 14.6 years, 7.7% of the participants (n = 614) developed dementia. +4 more findings

• Health Equity
• Risk Factors

Full summary, score breakdown and related studies → Original source

An evaluation of a community dementia screening program in rural Kenya: DEM‐SKY

38/100 ✓ Peer-reviewed Disparities Alzheimer s & Dementia

Key finding: The program demonstrated good acceptability, adoption, and fidelity and was effective in instigating behavior change. +4 more findings

• Health Equity
• Diagnosis

Full summary, score breakdown and related studies → Original source

Service delivery and the role of clinical pharmacists in UK primary care for older people, including people with dementia: a scoping review

45/100 ✓ Peer-reviewed Caregiving BMC Family Practice

Key finding: These detail the multifaceted responsibilities of clinical pharmacists in primary care for older people. +4 more findings

• Care Services
• Health Equity

Full summary, score breakdown and related studies → Original source

Barriers and facilitators to implementing person-centred dementia care in long-term care facilities in Western and Asian countries: a scoping review

49/100 ✓ Peer-reviewed Caregiving Frontiers in Psychiatry

Key finding: Over half were conducted in Western countries (n =20). +4 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

Neuraminidase 1 regulates neuropathogenesis by governing the cellular state of microglia via modulation of Trem2 sialylation

46/100 ✓ Peer-reviewed Tau biomarkers Cell reports

Key finding: As such, NEU1 regulates immune cells, primarily those of the monocytic lineage. +3 more findings

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Pathways to Racial/Ethnic Inequalities in Dementia

43/100 ✓ Peer-reviewed Disparities Annual review of clinical psychology

Key finding: This health inequality reflects structural racism, which creates and sustains racial differences in social determinants of health, including education access and quality, economic stability, social and community context, neighborhood and built environment, and health care access and quality. +4 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source

Point of view: Challenges in implementation of new immunotherapies for Alzheimer's disease

46/100 ✓ Peer-reviewed Health systems and care delivery The journal of prevention of Alzheimer's disease

Key finding: The advancement of disease-modifying treatments (DMTs) for Alzheimer's disease (AD), along with the approval of three amyloid-targeting therapies in the US and several other countries, represents a significant development in the treatment landscape, offering new hope for addressing this once untreatable chronic progressive disease. +2 more findings

• Care Services
• Treatments
• Policy

Full summary, score breakdown and related studies → Original source

Neighborhood environment associations with cognitive function and structural brain measures in older African Americans

54/100 ✓ Peer-reviewed Risk factors BMC medicine

Key finding: Since older adults spend significant time in their neighborhood environment, environmental factors such as neighborhood socioeconomic disadvantage, high racial segregation, low healthy food availability, low access to recreation, and minimal social engagement may have adverse effects on cognitive function and increase susceptibility to dementia. +4 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source

Low-dose intranasal deferoxamine modulates memory, neuroinflammation, and the neuronal transcriptome in the streptozotocin rodent model of Alzheimer’s disease

42/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in Neuroscience

Key finding: Five weeks of daily IN dosing of Long Evans rats with 15 μL of a 1% (0.3 mg), but not 0.1% (0.03 mg), solution of DFO rescued cognitive impairment caused by ICV STZ administration as assessed with the Morris Water Maze (MWM) test of spatial memory and learning. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis

44/100 ✓ Peer-reviewed Inflammation and the immune system Molecular Neurodegeneration

Key finding: Here, we found that the level of histone deacetylase 7 (HDAC7) was remarkably increased in the astrocytes of AD patients and P301S tau transgenic (PS19) mice. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Mitochondria-derived vesicles: New players in the game of neurodegeneration

32/100 ✓ Peer-reviewed Risk genes beyond APOE Neural Regeneration Research

Key finding: MDVs are small vesicles that bud from mitochondria and play an important role in removing damaged mitochondrial components. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Neuropsychological and clinical indicators of Lewy body and Alzheimer's pathology

37/100 ✓ Peer-reviewed Lewy body dementia Journal of Alzheimer s Disease Reports

Key finding: Gait disturbances (odds ratio (OR) = 19.32; p = 0.01), visual-spatial complaints (OR = 6.06; p = 0.03), and visual hallucinations (OR = 31.06; p = 0.002) predicted DLB compared to AD, along with better memory (OR = 3.42; p = 0.003), naming (OR = 3.35; p = 0.002), and worse processing speed (OR = 0.51; p = 0.01). +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Longitudinal FDG-PET Metabolic Change Along the Lewy Body Continuum

61/100 ✓ Peer-reviewed Lewy body dementia JAMA Neurology

Key finding: Thirty-five patients with probable DLB, 37 patients with MCI-LB, and 100 individuals without cognitive impairment were included. +4 more findings

• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source