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Microglial Reactivity Correlates with Presynaptic Loss Independent of β-Amyloid and Tau
Lan G, Chen X, Yang J, Sun P, Cai Y, Li A, Zhu Y, Liu Z et al.. Annals of neurology, 2024-02-14
Topic: Brain proteins, microglia and lab models
Objective Triggering receptor expressed on myeloid cells-2 (TREM2) and progranulin (PGRN) are critical regulators of microglia activation and can be detected in cerebrospinal fluid (CSF). However, whether microglial reactivity is detrimental or neuroprotective for Alzheimer disease (AD) is still debatable. Methods We identified 663 participants with baseline β-amyloid (Aβ) positron emission tomography (PET) and CSF biomarker data, including phosphorylated tau181 (p-Tau 181 ), soluble TREM2 (sTREM2), PGRN, and growth-associated protein-43 (GAP-43).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Lan, G., Chen, X., Yang, J., Sun, P., Cai, Y., Li, A., et al. (2024). Microglial Reactivity Correlates with Presynaptic Loss Independent of β-Amyloid and Tau. Annals of neurology. https://doi.org/10.1002/ana.26885
Vancouver
Lan G, Chen X, Yang J, Sun P, Cai Y, Li A, et al. Microglial Reactivity Correlates with Presynaptic Loss Independent of β-Amyloid and Tau. Annals of neurology. 2024. doi:10.1002/ana.26885. PMID: 38356322.
BibTeX
@article{lan2024-38356322,
author = {Lan, G. and Chen, X. and Yang, J. and Sun, P. and Cai, Y. and Li, A. and Zhu, Y. and Liu, Z. and others},
title = {{Microglial Reactivity Correlates with Presynaptic Loss Independent of β-Amyloid and Tau}},
journal = {Annals of neurology},
year = {2024},
doi = {10.1002/ana.26885},
pmid = {38356322},
url = {https://doi.org/10.1002/ana.26885}
}
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Key findings
- However, whether microglial reactivity is detrimental or neuroprotective for Alzheimer disease (AD) is still debatable.
- Methods We identified 663 participants with baseline β-amyloid (Aβ) positron emission tomography (PET) and CSF biomarker data, including phosphorylated tau181 (p-Tau 181 ), soluble TREM2 (sTREM2), PGRN, and growth-associated protein-43 (GAP-43).
- Among them, 254 participants had concurrent longitudinal CSF biomarkers.
- We used multivariate regression analysis to study the associations of CSF microglial biomarkers with Aβ PET, CSF p-Tau 181 , and CSF GAP-43 cross-sectionally and longitudinally.
Why it matters
In 663 participants, microglial reactivity measured by cerebrospinal fluid sTREM2 and PGRN was related to presynaptic loss independently of amyloid and tau, though whether microglial reactivity helps or harms in Alzheimer's remains debated. It is a biomarker association study, so it does not show a treatment, cure or prevention.
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Study details
- Study designlongitudinal study
- Participants65
- Evidence strengthModerate
How this study scored 57/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomized / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 55 of the 96 points we could judge it on, which is 57 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Annals of neurology) |
| Journal's citation record | 3 / 4 | Annals of Neurology: journal h-index 437 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 1 / 4 | 65 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 3 / 7 | Cited 17 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 4.2 citations a year over 4 year(s) since 2024 |
| Impact for its field and year | 2 / 6 | Cited 2.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 2 / 4 | Cited 17 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 1 / 3 | Tsinghua University: institution h-index 1,218 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38356322) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 55 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 55 of the 96 points we could judge it on is 57 out of 100. |
| Total | 57 / 100 | — |
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