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TREM2 promotes macrophage polarization from M1 to M2 and suppresses osteoarthritis through the NF-κB/CXCL3 axis
Fang C, Zhong R, Lu S, Yu G, Liu Z, Yan C, Gao J, Tang Y et al.. International journal of biological sciences, 2024-03-11
Topic: Brain proteins, microglia and lab models
Objective: Osteoarthritis (OA) is the most prominent chronic arthritic disease, affecting over 3 billion people globally. Synovial macrophages, as immune cells, play an essential role in cartilage damage in OA. Therefore, regulating macrophages is crucial for controlling the pathological changes in OA.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Fang, C., Zhong, R., Lu, S., Yu, G., Liu, Z., Yan, C., et al. (2024). TREM2 promotes macrophage polarization from M1 to M2 and suppresses osteoarthritis through the NF-κB/CXCL3 axis. International journal of biological sciences. https://doi.org/10.7150/ijbs.91519
Vancouver
Fang C, Zhong R, Lu S, Yu G, Liu Z, Yan C, et al. TREM2 promotes macrophage polarization from M1 to M2 and suppresses osteoarthritis through the NF-κB/CXCL3 axis. International journal of biological sciences. 2024. doi:10.7150/ijbs.91519. PMID: 38617547.
BibTeX
@article{fang2024-38617547,
author = {Fang, C. and Zhong, R. and Lu, S. and Yu, G. and Liu, Z. and Yan, C. and Gao, J. and Tang, Y. and others},
title = {{TREM2 promotes macrophage polarization from M1 to M2 and suppresses osteoarthritis through the NF-κB/CXCL3 axis}},
journal = {International journal of biological sciences},
year = {2024},
doi = {10.7150/ijbs.91519},
pmid = {38617547},
url = {https://doi.org/10.7150/ijbs.91519}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Synovial macrophages, as immune cells, play an essential role in cartilage damage in OA.
- Therefore, regulating macrophages is crucial for controlling the pathological changes in OA.
- Triggering receptor expressed on myeloid cells 2 (TREM2), as expressed on immune cell surfaces, such as macrophages and dendritic cells, has suppressed inflammation and regulated M2 macrophage polarization but demonstrated an unknown role in synovial macrophage polarization in OA.
- This study aimed to investigate TREM2 expression downregulation in OA mice macrophages.
Why it matters
This study is about osteoarthritis, not Alzheimer's disease, and examines how TREM2 affects macrophage polarization in that condition. It provides no information on treating, curing or preventing Alzheimer's disease.
New to this subject? Start with our plain-English guide: Genetics →
Study details
- Evidence strengthLow
How this study scored 49/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (International journal of biological sciences) |
| Journal's citation record | 2 / 4 | International Journal of Biological Sciences: journal h-index 164 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 128 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 32.0 citations a year over 4 year(s) since 2024 |
| Impact for its field and year | 5 / 6 | Cited 35.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 3 / 4 | Cited 127 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Xinzhe Feng: h-index 10 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Science and Technology of China: institution h-index 1,001 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38617547) |
| Free to read | 2 / 2 | Free to read |
| Total | 49 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.7150/ijbs.91519
- PubMed: 38617547
- Original source →
- Free full text: International Journal of Biological Sciences →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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