Newest studies

A proof of concept phase II study with the PDE-4 inhibitor roflumilast in patients with mild cognitive impairment or mild Alzheimer's disease dementia (ROMEMA): study protocol of a double-blind, randomized, placebo-controlled, between-subjects trial

54/100 ✓ Peer-reviewed Clinical trials Trials

Key finding: The outcomes of the present study aim to elucidate the significance of the PDE4 inhibition mechanism as a prospective therapeutic target for enhancing cognitive function in individuals with (a)MCI and mild AD dementia. +4 more findings

• Clinical Trials
• Treatments
• Early Stage

Full summary, score breakdown and related studies → Original source

Altered structural and functional connectivity in Posterior Cortical Atrophy and Dementia with Lewy bodies

43/100 ✓ Peer-reviewed Brain scans and imaging NeuroImage

Key finding: On DTI, PCA showed degeneration in occipito-parietal white matter, posterior thalamic radiations, splenium of the corpus collosum and sagittal stratum compared to DLB and CU, with greater degeneration in the temporal white matter and the fornix compared to CU. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

More failure with solanezumab - this time in preclinical Alzheimer's disease

41/100 ✓ Peer-reviewed Treatments Expert opinion on biological therapy

Key finding: In the A4 study, solanezumab did not reduce the decline in cognition or function and had no effect on brain amyloid burden.

• Clinical Trials
• Treatments
• Early Stage

Full summary, score breakdown and related studies → Original source

Cognitive reserve proxies for individuals with intellectual developmental disability: A scoping review

43/100 ✓ Peer-reviewed Risk factors Journal of applied research in intellectual disabilities : JARID

Key finding: Some of these were the same already detected in a population without intellectual disabilities (education, occupation, physical activity, leisure, community and social activities); others were found to be specifically relevant for this population: type of schooling, parental educational level, environmental stimulation and living place. +2 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

Customized Intranasal Hydrogel Delivering Methylene Blue Ameliorates Cognitive Dysfunction against Alzheimer's Disease

41/100 ✓ Peer-reviewed Drug development Advanced materials (Deerfield Beach, Fla.)

Key finding: These findings highlight a potential strategy for brain-targeted drug delivery in the management of the complex pathologies of AD.

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Comparative Efficacy and Safety of Monoclonal Antibodies for Cognitive Decline in Patients with Alzheimer's Disease: A Systematic Review and Network Meta-Analysis

84/100 ✓ Peer-reviewed Treatments CNS drugs

Key finding: Despite immunotherapies significantly increasing the risks of adverse events and ARIA, the data suggest that mAbs can effectively improve the cognitive function of patients with mild and moderate AD. +4 more findings

• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

Healthy Lifestyle and Cognition in Older Adults With Common Neuropathologies of Dementia

72/100 ✓ Peer-reviewed Prevention trials JAMA neurology

Key finding: Of 586 included decedents, 415 (70.8%) were female, 171 (29.2%) were male, and the mean (SD) age at death was 90.9 (6.0) years. +4 more findings

• Lifestyle

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Differences in Home Health Services and Outcomes Between Traditional Medicare and Medicare Advantage

57/100 ✓ Peer-reviewed Health systems and care delivery JAMA Health Forum

Key finding: Of 285 297 total patients, 180 283 (63.2%) were female; 586 (0.2%) were American Indian/Alaska Native, 8957 (3.1%) Asian, 28 694 (10.1%) Black, 7406 (2.6%) Hispanic, 1959 (0.7%) Native Hawaiian/Pacific Islander, 237 017 (83.1%) non-Hispanic White, and 678 (0.2%) multiracial individuals. +4 more findings

• Care Services
• Policy

Full summary, score breakdown and related studies → Original source

CSF Biomarkers in Longitudinal Alzheimer Disease Cohorts: Pre-Analytic Challenges

56/100 ✓ Peer-reviewed Tau biomarkers Clinical chemistry

Key finding: The sensitivity of amyloid to pre-analytic factors complicates cerebrospinal fluid (CSF) diagnostics for Alzheimer disease. +3 more findings

• Biomarkers

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Sedentary behavior and lifespan brain health

53/100 ✓ Peer-reviewed Digital health tools Trends in cognitive sciences

Key finding: Higher levels of physical activity are known to benefit aspects of brain health across the lifespan. +4 more findings

• Digital Tools

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Biomarker-based staging of Alzheimer disease: rationale and clinical applications

56/100 ✓ Peer-reviewed Biomarkers Nature reviews. Neurology

Key finding: Focusing on the key principles of disease staging shared across several areas of medicine, this Review highlights the potential for in vivo staging of AD to transform our understanding of preclinical AD, refine enrolment criteria for trials of disease-modifying therapies and aid clinical decision-making in the era of anti-amyloid therapeutics. +4 more findings

• Biomarkers
• Treatments

Full summary, score breakdown and related studies → Original source

Diagnostic Accuracy of a Plasma Phosphorylated Tau 217 Immunoassay for Alzheimer Disease Pathology

84/100 ✓ Peer-reviewed Biomarkers JAMA Neurology

Key finding: This study found that a commercially available plasma p-tau217 immunoassay accurately identified biological AD, comparable with results using CSF biomarkers, with reproducible cut-offs across cohorts. +2 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

ASOs are an effective treatment for disease-associated oligodendrocyte signatures in premanifest and symptomatic SCA3 mice

43/100 ✓ Peer-reviewed Drug development Molecular therapy : the journal of the American Society of Gene Therapy

Key finding: Our results highlight the promising use of an ASO therapy across neurodegenerative diseases that requires glial targeting in addition to affected neuronal populations.

• Treatments
• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Digital computerised cognitive training for preventing cognitive decline among hypertensive patients: a study protocol for a multicentre randomised controlled trial (DELIGHT trial)

52/100 ✓ Peer-reviewed Cognitive tests and assessment BMJ open

Key finding: Hypertension is associated with impaired cognition, and when combined with MCI, it may lead to a poor prognosis.

• Clinical Trials
• Digital Tools
• Prevention

Full summary, score breakdown and related studies → Original source

Intersectin - many facets of a scaffold protein

43/100 ✓ Peer-reviewed Prevention trials Biochemical Society transactions

Key finding: Each ITSN gene encodes two major isoforms, ITSN-Long (ITSN-L) and ITSN-Short (ITSN-S), due to alternative splicing. +4 more findings

Full summary, score breakdown and related studies → Original source

Multisensory gamma stimulation promotes glymphatic clearance of amyloid

50/100 ✓ Peer-reviewed Disease mechanisms Nature

Key finding: Influx of cerebrospinal fluid was associated with increased aquaporin-4 polarization along astrocytic endfeet and dilated meningeal lymphatic vessels. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

The Bio-Hermes Study: Biomarker database developed to investigate blood-based and digital biomarkers in community-based, diverse populations clinically screened for Alzheimer's disease

57/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Blood-based biomarkers are highly associated with amyloid PET/CSF results in diverse populations enrolled at clinical trial sites. +2 more findings

• Biomarkers
• Genetics
• Health Equity

Full summary, score breakdown and related studies → Original source

National Estimates of Short- and Longer-Term Hospital Readmissions After Major Surgery Among Community-Living Older Adults

62/100 ✓ Peer-reviewed Health systems and care delivery JAMA Network Open

Key finding: A total of 1780 major operations (representing 9 556 171 survey-weighted operations nationally) were identified from 1477 community-living participants; mean (SD) age was 79.5 (7.0) years, with 56% being female. +4 more findings

• Care Services

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Nutritional Interventions for the Prevention of Cognitive Decline in Patients With Mild Cognitive Impairment and Alzheimer Disease: Protocol for a Network Meta-Analysis of Randomized Controlled Trials

52/100 ✓ Peer-reviewed Treatments JMIR research protocols

Key finding: People with MCI are at increased risk of developing AD. +4 more findings

• Early Stage
• Lifestyle

Full summary, score breakdown and related studies → Original source

Age-Related Pathology in Corticobasal Degeneration

52/100 ✓ Peer-reviewed Brain tissue and pathology International journal of molecular sciences

Key finding: Three cases (14.3%) had Lewy body pathology. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Single-nucleus RNA sequencing demonstrates an autosomal dominant Alzheimer's disease profile and possible mechanisms of disease protection

43/100 ✓ Peer-reviewed Genetics Neuron

Key finding: Highly penetrant autosomal dominant Alzheimer's disease (ADAD) comprises a distinct disease entity as compared to the far more prevalent form of AD in which common variants collectively contribute to risk. +2 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Polygenic effects on the risk of Alzheimer's disease in the Japanese population

55/100 ✓ Peer-reviewed Genetics Alzheimer's research & therapy

Key finding: The PRS using 131 SNPs had an effect independent of APOE. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Dual-task turn velocity - a novel digital biomarker for mild cognitive impairment and dementia

55/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in aging neuroscience

Key finding: Our results demonstrated that dual-task could significantly improve the ability to predict cognitive impairment based on gait parameters such as gait speed (GS) and stride length (SL). +4 more findings

• Biomarkers
• Early Stage
• Digital Tools

Full summary, score breakdown and related studies → Original source

Blood-based biomarkers of cerebral small vessel disease

43/100 ✓ Peer-reviewed Biomarkers Ageing research reviews

Key finding: As a result, there has been a recent proliferation of blood-based biomarker studies for CSVD aimed at developing accessible screening tools for early detection and risk stratification. +1 more finding

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Availability and use of telehealth services among patients with ADRD enrolled in traditional Medicare vs. Medicare advantage during the COVID-19 pandemic

41/100 ✓ Peer-reviewed Health systems and care delivery Frontiers in Public Health

Key finding: There were 13,700 beneficiaries with full-year enrollment in MA (6,046) or TM (7,724), 518 with ADRD and 13,252 without ADRD. +4 more findings

• Digital Tools
• Health Equity
• Policy

Full summary, score breakdown and related studies → Original source