Newest studies

Potential of dietary polyphenols for protection from age-related decline and neurodegeneration: a role for gut microbiota?

41/100 ✓ Peer-reviewed Prevention trials Nutritional neuroscience

Key finding: Many epidemiological studies have shown the beneficial effects of a largely plant-based diet, and the strong association between the consumption of a Mediterranean-type diet with healthy aging including a lower risk of cognitive decline. +2 more findings

• Lifestyle
• Risk Factors

Full summary, score breakdown and related studies → Original source

Cognition and Cognitive Reserve

43/100 ✓ Peer-reviewed Risk factors Integrative psychological & behavioral science

Key finding: Also, several lines of studies have found that the plasticity between neurons has a significant impact on cognitive reserve and acts against cognitive decline.

Full summary, score breakdown and related studies → Original source

Head-to-head comparison of [18F]-Flortaucipir, [18F]-MK-6240 and [18F]-PI-2620 postmortem binding across the spectrum of neurodegenerative diseases

46/100 ✓ Peer-reviewed Brain scans and imaging Acta neuropathologica

Key finding: We and others have shown that [18F]-Flortaucipir, the most validated tau PET tracer thus far, binds with strong affinity to tau aggregates in Alzheimer's (AD) but has relatively low affinity for tau aggregates in non-AD tauopathies and exhibits off-target binding to neuromelanin- and melanin-containing cells, and to hemorrhages. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

The impact of the implementation of a national policy on dementia on healthcare costs in older patients with dementia in Korea: a quasi-experimental difference-in-difference study

40/100 ✓ Peer-reviewed Health systems and care delivery The Lancet Regional Health - Western Pacific

Key finding: Policy implementation was associated with a significant decrease in patient out-of-pocket cost. +4 more findings

• Policy

Full summary, score breakdown and related studies → Original source

A fluid biomarker reveals loss of TDP-43 splicing repression in presymptomatic ALS-FTD

50/100 ✓ Peer-reviewed Biomarkers Nature medicine

Key finding: Cryptic hepatoma-derived growth factor-like protein 2 (HDGFL2) accumulates in CSF at significantly higher levels in familial ALS-FTD and sporadic ALS compared with controls and is elevated earlier than neurofilament light and phosphorylated neurofilament heavy chain protein levels in familial disease. +1 more finding

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Nanoencapsulated Curcumin: Enhanced Efficacy in Reversing Memory Loss in An Alzheimer Disease Model

38/100 ✓ Peer-reviewed Biomarkers Brain sciences

Key finding: NC Curc significantly reversed memory deficits in object recognition and inhibitory avoidance tests induced by STZ. +2 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Diacylglycerols and Lysophosphatidic Acid, Enriched on Lipoprotein(a), Contribute to Monocyte Inflammation

51/100 ✓ Peer-reviewed TREM2 and immune genetics Arteriosclerosis, thrombosis, and vascular biology

Key finding: Oxidized phospholipids play a key role in the atherogenic potential of lipoprotein(a) (Lp[a]); however, Lp(a) is a complex particle that warrants research into additional proinflammatory mediators. +3 more findings

Full summary, score breakdown and related studies → Original source

A blood biomarker of the pace of aging is associated with brain structure: replication across three cohorts

45/100 ✓ Peer-reviewed Biomarkers Neurobiology of aging

Key finding: A novel epigenetic measure of biological aging, DunedinPACE, is associated with cognitive dysfunction, incident dementia, and mortality. +2 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Potential Effects of Long-Term Exposure to Air Pollution on Dementia: A Longitudinal Analysis in American Indians Aged 55 Years and Older

54/100 ✓ Peer-reviewed Risk factors International Journal of Environmental Research and Public Health

Key finding: The average PM2.5 levels in the IHS counties were lower than those in all US counties, while the mean O3 levels in the IHS counties were higher than the US counties. +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Mapping racial and ethnic healthcare disparities for persons living with dementia: A scoping review

53/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Future studies need to examine underlying processes and develop interventions to reduce disparities while also being more broadly inclusive of diverse populations.

• Health Equity
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

The development and validation of a digital biomarker for remote assessment of Alzheimer's diseases risk

50/100 ✓ Peer-reviewed Cognitive tests and assessment Digital health

Key finding: ANOVA and Bayesian t-test found no significant differences between the task when it was remotely self-administered by participants at home compared to when it was taken under controlled lab conditions. +3 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source

Blood-based biomarkers in Alzheimer's disease - moving towards a new era of diagnostics

41/100 ✓ Peer-reviewed Biomarkers Clinical chemistry and laboratory medicine

Key finding: This paper briefly evaluates the clinical utility and reliability of these biomarkers across various AD stages, highlighting challenges like refining plasma Aβ42/Aβ40 assays and enhancing the precision of p-tau, particularly p-tau181, p-tau217, and p-tau231. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Plasma metabolic profiles predict future dementia and dementia subtypes: a prospective analysis of 274,160 participants

65/100 ✓ Peer-reviewed Digital health tools Alzheimer's research & therapy

Key finding: We conducted the largest metabolome investigation of dementia to date, for the first time revealed the metabolite importance ranking, and highlighted the contribution of plasma metabolites for dementia prediction. +4 more findings

Full summary, score breakdown and related studies → Original source

Epidemiology, Pathophysiology, and Imaging of Atherosclerotic Intracranial Disease

50/100 ✓ Peer-reviewed Disparities Stroke

Key finding: Among people with stroke, those of East Asia descent and non-White populations in the United States have a higher burden of ICAD-related stroke compared with Whites of European descent.

• Brain Scans

Full summary, score breakdown and related studies → Original source

Associations between sleep-behavioral traits and healthspan: A one-sample Mendelian randomization study based on 388,909 participants of the UK-Biobank

57/100 ✓ Peer-reviewed Risk factors Journal of affective disorders

Key finding: In IPTW, we observed a decreased risk of terminated healthspan for healthy sleep behaviors such as 'sleep duration 7-8h/d' (Hazard ratio, HR = 0.93; 95 % confidence interval, CI: 0.92-0.96; P < 0.001); 'morningness' (HR = 0.95; 95%CI: 0.93-0.98; P < 0.01); 'napping' (HR = 0.93; 95%CI: 0.91-0.94; P < 0.001); 'easy getting up from bed' (HR = 0.91; 95%CI: 0.88-0.93; P < 0.001); and, 'never/rarely experience sleeplessness/insomnia' (HR = 0.94; 95%CI: 0.92-0.96; P < 0.001). +4 more findings

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Comparative efficacy, tolerability and acceptability of donanemab, lecanemab, aducanumab and lithium on cognitive function in mild cognitive impairment and Alzheimer's disease: A systematic review and network meta-analysis

82/100 ✓ Peer-reviewed Treatments Ageing research reviews

Key finding: The analysis included 8 randomized placebo-controlled trials with 6547 participants. +4 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Multi-Omic Blood Biomarkers as Dynamic Risk Predictors in Late-Onset Alzheimer's Disease

43/100 ✓ Peer-reviewed Genetics International journal of molecular sciences

Key finding: Blood biomarkers, including genetics, proteins and metabolites, are emerging as powerful predictors of Alzheimer's disease at various timepoints within the disease course, including at the preclinical stage. +4 more findings

• Genetics
• Biomarkers

Full summary, score breakdown and related studies → Original source

TREM2 in Alzheimer's disease: Structure, function, therapeutic prospects, and activation challenges

43/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular and cellular neurosciences

Key finding: Given the significant challenges associated with the activation of TREM2, particularly due to its diverse isoforms and the delicate balance required to modulate the immune response without triggering hyperactivation, this review aims to enhance our understanding of TREM2 in AD and inspire further research into this promising yet challenging therapeutic target.

• Genetics
• Treatments

Full summary, score breakdown and related studies → Original source

Risk factors in developing amyloid related imaging abnormalities (ARIA) and clinical implications

45/100 ✓ Peer-reviewed Treatments Frontiers in neuroscience

Key finding: The advent of new anti-amyloid monoclonal antibodies as treatment for early Alzheimer's disease these immunotherapeutics may slow disease progression but also pose significant risks. +1 more finding

• Treatments
• Brain Scans
• Side Effects

Full summary, score breakdown and related studies → Original source

The contribution of age-related changes in the gut-brain axis to neurological disorders

43/100 ✓ Peer-reviewed Disease mechanisms Gut microbes

Key finding: Recent advances in metagenomics and metabolomics have revealed that the gut microbiota plays a critical role in the regulation of host immunity and metabolism, communicating through bidirectional interactions in the microbiota-gut-brain axis (MGBA). +1 more finding

Full summary, score breakdown and related studies → Original source

Cognitive change in prevalent and incident hearing loss: The Maastricht Aging Study

57/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Participants with prevalent and incident HL showed a faster decline in verbal memory, information processing speed, and executive function than participants without HL. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Enablers and Barriers to Hearing aid Use in People Living With Dementia

71/100 ✓ Peer-reviewed Risk factors Journal of applied gerontology : the official journal of the Southern Gerontological Society

Key finding: Our findings suggest that the TDF domains environmental context and resources, behavioral regulation, reinforcement, and social influences are of greatest relevance to hearing aid use in dementia. +1 more finding

• Clinical Trials
• Lifestyle

Full summary, score breakdown and related studies → Original source

Impact of Sleep Disorders and Disturbed Sleep on Brain Health: A Scientific Statement From the American Heart Association

43/100 ✓ Peer-reviewed Risk factors Stroke

Key finding: Sleep disorders such as sleep-disordered breathing (eg, obstructive sleep apnea), and other sleep disturbances, as well, some of which are also considered sleep disorders (eg, insomnia, sleep fragmentation, circadian rhythm disorders, and extreme sleep duration), have been associated with adverse brain health.

• Biomarkers
• Lifestyle

Full summary, score breakdown and related studies → Original source

Reconsidering repurposing: long-term metformin treatment impairs cognition in Alzheimer's model mice

43/100 ✓ Peer-reviewed Drug development Translational psychiatry

Key finding: Nevertheless, some studies have demonstrated that metformin may trigger AD pathology and even elevate AD risk in humans. +3 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Deciphering ApoE Genotype-Driven Proteomic and Lipidomic Alterations in Alzheimer's Disease Across Distinct Brain Regions

43/100 ✓ Peer-reviewed Genetics Journal of proteome research

Key finding: Lipid and protein perturbations were assessed across AD diagnosed brains compared to Ctrl brains, ε4 allele carriers (APOE4+ for those carrying 1 or 2 ε4s and APOE4- for non-ε4 carriers), and differences in ε3ε3 and ε3ε4 Ctrl brains across two brain regions (frontal cortex (FCX) and cerebellum (CBM)).

• Genetics

Full summary, score breakdown and related studies → Original source