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Diffusion MRI relates to plasma Aβ42/40 in PET negative participants without dementia
Jesse C DeSimone, Wei-En Wang, David A Loewenstein, Ranjan Duara, Glenn E Smith, Karen N McFarland, Melissa J Armstrong, Darren M Weber et al.. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024-03-05
Topic: Plasma and spinal-fluid biomarkers
Plasma+/PET- demonstrated increased FW (24 regions) and decreased FAt (66 regions) compared to plasma-/PET-. FW (16 regions) and FAt (51 regions) were increased in plasma+/PET+ compared to plasma+/PET-. Composite brain FW correlated with plasma Aβ42/40 and p-tau181. FW imaging changes distinguish plasma Aβ42/40 positive and negative groups, independent of group differences in cognitive status, Aβ PET status, and other plasma biomarkers (i.e., t-tau, p-tau181, glial fibrillary acidic protein, neurofilament light). HIGHLIGHTS: Plasma Aβ42/40 positivity is associated with brain microstructure decline. Plasma+/PET- demonstrated increased FW in 24 total GM and WM regions. Plasma+/PET- demonstrated decreased FAt in 66 total GM and WM regions. Whole-brain FW correlated with plasma Aβ42/40 and p-tau181 measures. Plasma+/PET- demonstrated decreased cortical volume and thickness.
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APA 7th
DeSimone, J. C., Wang, W.-E., Loewenstein, D. A., Duara, R., Smith, G. E., McFarland, K. N., et al. (2024). Diffusion MRI relates to plasma Aβ42/40 in PET negative participants without dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.13693
Vancouver
DeSimone JC, Wang W.-E, Loewenstein DA, Duara R, Smith GE, McFarland KN, et al. Diffusion MRI relates to plasma Aβ42/40 in PET negative participants without dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024. doi:10.1002/alz.13693. PMID: 38441274.
BibTeX
@article{desimone2024-38441274,
author = {DeSimone, Jesse C and Wang, Wei-En and Loewenstein, David A and Duara, Ranjan and Smith, Glenn E and McFarland, Karen N and Armstrong, Melissa J and Weber, Darren M and others},
title = {{Diffusion MRI relates to plasma Aβ42/40 in PET negative participants without dementia}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2024},
doi = {10.1002/alz.13693},
pmid = {38441274},
url = {https://doi.org/10.1002/alz.13693}
}
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Key findings
- Plasma+/PET- demonstrated increased FW (24 regions) and decreased FAt (66 regions) compared to plasma-/PET-.
- FW (16 regions) and FAt (51 regions) were increased in plasma+/PET+ compared to plasma+/PET-.
- Composite brain FW correlated with plasma Aβ42/40 and p-tau181.
- FW imaging changes distinguish plasma Aβ42/40 positive and negative groups, independent of group differences in cognitive status, Aβ PET status, and other plasma biomarkers (i.e., t-tau, p-tau181, glial fibrillary acidic protein, neurofilament light).
- HIGHLIGHTS: Plasma Aβ42/40 positivity is associated with brain microstructure decline.
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Study details
- Evidence strengthLow
How this study scored 46/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 26 of the 56 points we could judge it on, which is 46 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38441274) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 26 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 26 of the 56 points we could judge it on is 46 out of 100. |
| Total | 46 / 100 | — |
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