Newest studies

Palliative Care in Early Dementia

64/100 ✓ Peer-reviewed End-of-life care Journal of pain and symptom management

Key finding: Among the 77 papers reviewed, few addressed early stages of dementia specifically. +4 more findings

• End-of-Life Care

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Early detection of dementia with default-mode network effective connectivity

66/100 ✓ Peer-reviewed Brain scans and imaging Nature. Mental health

Key finding: We investigated whether a neurobiological model of DMN effective connectivity could predict a future dementia diagnosis at the single-participant level. +4 more findings

• Diagnosis
• Brain Scans

Full summary, score breakdown and related studies → Original source

A single-cell and spatial RNA-seq database for Alzheimer's disease (ssREAD)

46/100 ✓ Peer-reviewed Genetics Nature communications

Key finding: Addressing this, we introduce a single-cell and spatial RNA-seq database for Alzheimer's disease (ssREAD). +4 more findings

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Racial and ethnic differences in telemedicine use among community-dwelling older adults with dementia

63/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society

Key finding: The analytical sample size of the study was 2,068,937, including 9.9% Black, 82.7% White, and 7.4% Hispanic individuals. +4 more findings

• Health Equity
• Digital Tools

Full summary, score breakdown and related studies → Original source

Resting-state networks and anosognosia in Alzheimer's disease

43/100 ✓ Peer-reviewed Brain scans and imaging Frontiers in aging neuroscience

Key finding: We found that anosognosia was associated with (i) weak functional connectivity within the DMN, in posterior and middle cingulate cortex particularly, (ii) strong functional connectivity within the SN in ACC, and between the SN and basal ganglia, and (iii) a heterogenous effect concerning the functional connectivity of the FPN, with a weak connectivity between the FPN and PCC, and a strong connectivity between the FPN and ACC. +2 more findings

Full summary, score breakdown and related studies → Original source

Needs analysis of family caregivers of people living with dementia in Sleman Regency, Yogyakarta

54/100 ✓ Peer-reviewed Caregiving Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

Key finding: The result of the validity test of the CNA-D instrument, Indonesian version, obtained a high value for content validity. +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Oxidative stress-mediated neuroinflammation in Alzheimer's disease

43/100 ✓ Peer-reviewed Inflammation and the immune system Naunyn-Schmiedeberg's archives of pharmacology

Key finding: Nonetheless, prolonged microglial activation is associated with Tau phosphorylation and Aβ aggregation. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Cognitive reserve, cortisol, and Alzheimer's disease biomarkers: A memory clinic study

57/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Higher CRI scores were associated with better cognition. +4 more findings

• Biomarkers
• Care Services

Full summary, score breakdown and related studies → Original source

SIMOA Diagnostics on Alzheimer's Disease and Frontotemporal Dementia

54/100 ✓ Peer-reviewed Biomarkers Biomedicines

Key finding: CSF exhibited increased levels of all SIMOA biomarkers in AD compared to Controls (AUCs: 0.71, 0.86, 0.92, and 0.94, respectively). +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

The African American Dementia and Aging Project (AADAPt): An Oregon-based Longitudinal Study

16/100 ⚠ Preprint — not yet peer-reviewed Disparities medRxiv : the preprint server for health sciences

Key finding: AADAPt participants had risk factors for developing dementia in future, such as hypertension and hyperlipidemia, but also reported protective factors such as high social engagement. +3 more findings

• Health Equity

Scored 45 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Intermittent hypoxia training enhances Aβ endocytosis by plaque associated microglia via VPS35-dependent TREM2 recycling in murine Alzheimer's disease

43/100 ✓ Peer-reviewed TREM2 and immune genetics Alzheimer's research & therapy

Key finding: Our results showed that IHT ameliorated cognitive function and Aβ pathology. +4 more findings

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Alzheimer-Type Cerebral Amyloidosis in the Context of HIV Infection: Implications for a Proposed New Treatment Approach

41/100 ✓ Peer-reviewed Tau biomarkers Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology

Key finding: Our study evaluates the hypothesis that reverse transcriptase inhibitors protect against Alzheimer-type brain amyloidogenesis in the context of HIV infection. +3 more findings

• Treatments

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Association of Plasma Amyloid, P-Tau, GFAP, and NfL With CSF, Clinical, and Cognitive Features in Patients With Dementia With Lewy Bodies

68/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: Our study suggests a possible utility of plasma Aβ42/40, P-tau181, and P-tau231 as a noninvasive biomarkers to assess amyloid copathology in DLB, and plasma GFAP and NfL as monitoring biomarkers for cognitive symptoms in DLB. +3 more findings

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Donanemab, another anti-Alzheimer's drug with risk and uncertain benefit

43/100 ✓ Peer-reviewed Treatments Ageing research reviews

Key finding: We believe that these findings are subject to misinterpretation and statistical bias. +2 more findings

• Treatments
• Brain Scans

Full summary, score breakdown and related studies → Original source

Impact of air pollution and climate change on mental health outcomes: an umbrella review of global evidence

81/100 ✓ Peer-reviewed Risk factors World psychiatry : official journal of the World Psychiatric Association (WPA)

Key finding: Regarding exposures to air pollution, there was convincing (class I) evidence for the association between long-term exposure to solvents and a higher incidence of dementia or cognitive impairment (odds ratio, OR=1.139), and highly suggestive (class II) evidence for the association between long-term exposure to some pollutants and higher risk for cognitive disorders (higher incidence of dementia with high vs. low levels of carbon monoxide, CO: OR=1.587; higher incidence of vascular dementia per 1 μg/m 3 increase of nitrogen oxides, NO x : hazard ratio, HR=1.004).

• Risk Factors

Full summary, score breakdown and related studies → Original source

Use of lecanemab for the treatment of Alzheimer's disease: A systematic review

76/100 ✓ Peer-reviewed Treatments Brain and behavior

Key finding: According to studies, lecanemab lessens clinical deterioration and reduces brain amyloid-beta plaques (difference,.45; 95% confidence interval,.67 to.23; p < .001).

• Treatments
• Side Effects
• Brain Biology

Full summary, score breakdown and related studies → Original source

Geographical variation in dementia prevalence across China: a geospatial analysis

60/100 ✓ Peer-reviewed Risk factors The Lancet Regional Health - Western Pacific

Key finding: The weighted prevalence of dementia at provincial level in China in 2018 ranged from 2.62% (95%BCI: 1.70%, 3.91%) to 13.53% (95%BCI: 8.82%, 20.93%). +4 more findings

• Risk Factors
• Policy

Full summary, score breakdown and related studies → Original source

The Devastation of Falls among Older Patients

25/100 ✓ Peer-reviewed Health systems and care delivery Emergency Medicine News

Key finding: Falls are an important event in a senior citizen's life, and offer the potential for significant morbidity and mortality. +4 more findings

• Side Effects

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New and emerging drug therapies for Alzheimer disease

41/100 ✓ Peer-reviewed Drug development Australian prescriber

Key finding: Biomarker measures of amyloid, tau and neurodegeneration have been integral to Alzheimer disease clinical trials for biologic drugs, for patient selection and efficacy monitoring. +3 more findings

• Treatments

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Design and Methods of the Early Age-Related Hearing Loss Investigation Randomized Controlled Trial

44/100 ✓ Peer-reviewed Treatments Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

Key finding: After its completion in 2028, the EARHLI trial should offer evidence on the effect of hearing treatment versus a health education control on cognitive performance, social engagement, and brain organization/connectivity in 55- to 75-year-old community-dwelling adults with early ARHL and amnestic mild cognitive impairment. +1 more finding

• Clinical Trials
• Risk Factors

Full summary, score breakdown and related studies → Original source

Comparative study of choline alfoscerate as a combination therapy with donepezil: A mixed double-blind randomized controlled and open-label observation trial

61/100 ✓ Peer-reviewed Treatments Medicine

Key finding: Choline alfoscerate exhibits additional cognitive improvement in both cognitive and noncognitive domains, supporting the findings of the ASCOMALVA trial. +1 more finding

• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease: The DIAN-TU-001 Randomized Clinical Trial

74/100 ✓ Peer-reviewed Biomarkers JAMA neurology

Key finding: Of 236 eligible participants screened, 43 were excluded. +1 more finding

• Clinical Trials
• Biomarkers
• Treatments

Full summary, score breakdown and related studies → Original source

Plasma VEGFA and PGF impact longitudinal tau and cognition in preclinical Alzheimer's disease

68/100 ✓ Peer-reviewed Biomarkers Brain : a journal of neurology

Key finding: Baseline plasma VEGFA and PGF each showed a significant interaction with amyloid burden on prospective cognitive decline. +4 more findings

• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Effective dosage and mode of exercise for enhancing cognitive function in Alzheimer's disease and dementia: a systematic review and Bayesian Model-Based Network Meta-analysis of RCTs

64/100 ✓ Peer-reviewed Treatments BMC Geriatrics

Key finding: Nonlinear dose-response relationship between exercise and cognitive improvement in Alzheimer's disease, with the optimal AE dose identified at 660 METs-min/week for enhancing cognitive function in AD. +2 more findings

• Lifestyle

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AdipoRon Ameliorates Synaptic Dysfunction and Inhibits tau Hyperphosphorylation through the AdipoR/AMPK/mTOR Pathway in T2DM Mice

43/100 ✓ Peer-reviewed Disease mechanisms Neurochemical research

Key finding: We found that AdipoRon significantly restored the cognitive deficits in T2DM mice, including shorter escape latency, more crossing times, increased distances, and percentage of time in the target quadrant. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source