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Hepatic danger signaling triggers TREM2+ macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation
Zhou L, Qiu X, Meng Z, Liu T, Chen Z, Zhang P, Kuang H, Pan T et al.. Science translational medicine, 2024-03-13
Topic: Brain proteins, microglia and lab models
Metabolic dysfunction-associated steatohepatitis (MASH), formerly known as nonalcoholic steatohepatitis (NASH), is an advanced stage of metabolic fatty liver disease. The pathogenic mechanisms of MASH center on hepatocyte injury and the ensuing immune response within the liver microenvironment. Recent work has implicated TREM2 + macrophages in various disease conditions, and substantial induction of TREM2 + NASH-associated macrophages (NAMs) serves as a hallmark of metabolic liver disease.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Zhou, L., Qiu, X., Meng, Z., Liu, T., Chen, Z., Zhang, P., et al. (2024). Hepatic danger signaling triggers TREM2+ macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation. Science translational medicine. https://doi.org/10.1126/scitranslmed.adk1866
Vancouver
Zhou L, Qiu X, Meng Z, Liu T, Chen Z, Zhang P, et al. Hepatic danger signaling triggers TREM2+ macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation. Science translational medicine. 2024. doi:10.1126/scitranslmed.adk1866. PMID: 38478630.
BibTeX
@article{zhou2024-38478630,
author = {Zhou, L. and Qiu, X. and Meng, Z. and Liu, T. and Chen, Z. and Zhang, P. and Kuang, H. and Pan, T. and others},
title = {{Hepatic danger signaling triggers TREM2+ macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation}},
journal = {Science translational medicine},
year = {2024},
doi = {10.1126/scitranslmed.adk1866},
pmid = {38478630},
url = {https://doi.org/10.1126/scitranslmed.adk1866}
}
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Key findings
- The pathogenic mechanisms of MASH center on hepatocyte injury and the ensuing immune response within the liver microenvironment.
- Recent work has implicated TREM2 + macrophages in various disease conditions, and substantial induction of TREM2 + NASH-associated macrophages (NAMs) serves as a hallmark of metabolic liver disease.
- Despite this, the mechanisms through which NAMs contribute to MASH pathogenesis remain poorly understood.
- Here, we identify membrane-spanning 4-domains a7 (MS4A7) as a NAM-specific pathogenic factor that exacerbates MASH progression in mice.
Why it matters
This study identifies MS4A7 as a driver by which TREM2+ macrophages contribute to metabolic dysfunction-associated steatohepatitis. It is about liver disease and not Alzheimer's disease, so it has no implications for treating, curing or preventing Alzheimer's.
New to this subject? Start with our plain-English guide: Genetics →
Study details
- Evidence strengthLow
How this study scored 47/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Science translational medicine) |
| Journal's citation record | 3 / 4 | Science Translational Medicine: journal h-index 365 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 70 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 17.5 citations a year over 4 year(s) since 2024 |
| Impact for its field and year | 4 / 6 | Cited 18.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 3 / 4 | Cited 70 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Jiandie D. Lin: h-index 69 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Michigan: institution h-index 2,240 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38478630) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 47 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1126/scitranslmed.adk1866
- PubMed: 38478630
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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