Newest studies

Macrophage diversity in human cancers: New insight provided by single-cell resolution and spatial context

48/100 ✓ Peer-reviewed TREM2 and immune genetics Heliyon

Key finding: Now it becomes clear that this dichotomy doesn't adequately reflect the diversity of macrophage phenotypes in tumor microenvironment (TME). +3 more findings

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Disease staging of Alzheimer's disease using a CSF-based biomarker model

69/100 ✓ Peer-reviewed Brain scans and imaging Nature aging

Key finding: SuStaIn identified a singular biomarker sequence and revealed that five CSF biomarkers effectively constituted a reliable staging model (ordered: Aβ42/40, pT217/T217, pT205/T205, MTBR-tau243 and non-phosphorylated mid-region tau). +3 more findings

• Biomarkers

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Proteomic analysis of P. gingivalis-Lipopolysaccharide induced neuroinflammation in SH-SY5Y and HMC3 cells

43/100 ✓ Peer-reviewed Inflammation and the immune system GeroScience

Key finding: In this study, we utilized data-independent acquisition mass spectrometry to characterize P.gingivalis-LPS induced profile of differentially expressed proteins associated with the neuroinflammatory response in human neuroblastoma (SH-SY5Y) and human microglial (HMC3) cells. +3 more findings

• Brain Biology

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Dementias Platform UK: Bringing genetics into life

46/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: The data processing pipelines, research-ready imputed genetic data, and PRS scores are now available on the DPUK platform and can be accessed upon request though the DPUK application process. +1 more finding

• Genetics

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P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy

43/100 ✓ Peer-reviewed Biomarkers Neuron

Key finding: Proteomic analysis revealed that mAb2A7 treatment reversed alterations mainly in proteins associated with synaptic functions observed in murine tauopathy and AD brain. +1 more finding

• Biomarkers
• Treatments
• Brain Biology

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Requesting That Delirium Achieve Parity With Acute Encephalopathy in the MS-DRG System

37/100 ✓ Peer-reviewed Health systems and care delivery Journal of the Academy of Consultation-Liaison Psychiatry

Key finding: Toxic and metabolic encephalopathy codes are designated as major complication or comorbidity, whereas causally specified delirium codes are designated as complication or comorbidity and thus associated with a lower reimbursement and lesser impact on value metrics. +1 more finding

• Policy

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On the Opportunities and Challenges of Foundation Models for GeoAI (Vision Paper)

48/100 ✓ Peer-reviewed Risk factors ACM Transactions on Spatial Algorithms and Systems

Key finding: Our results indicate that on several geospatial tasks that only involve text modality, such as toponym recognition, location description recognition, and US state-level/county-level dementia time series forecasting, the task-agnostic large learning models (LLMs) can outperform task-specific fully supervised models in a zero-shot or few-shot learning setting. +1 more finding

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Racial and ethnic differences in disease course Medicare expenditures for beneficiaries with dementia

53/100 ✓ Peer-reviewed Costs and economics Journal of the American Geriatrics Society

Key finding: NH Black and Hispanic beneficiaries with dementia had higher disease course Medicare expenditures than NH Whites.

• Health Equity
• Policy

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Transient sleep apnea results in long-lasting increase in β-amyloid generation and tau hyperphosphorylation

43/100 ✓ Peer-reviewed Risk factors Neuroscience research

Key finding: These results suggest that even transient IHT may be sufficient to cause long-lasting changes in the molecules measured as AD biomarkers in the brain.

• Brain Biology

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CVOT Summit Report 2023: new cardiovascular, kidney, and metabolic outcomes

43/100 ✓ Peer-reviewed Drug development Cardiovascular diabetology

Key finding: It is generally assumed that treatment of chronic diseases is equally effective for all patients. +4 more findings

• Treatments
• Risk Factors

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APOE2 gene therapy reduces amyloid deposition and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease

45/100 ✓ Peer-reviewed Disease mechanisms Molecular therapy : the journal of the American Society of Gene Therapy

Key finding: The contrast is especially stark when compared with the major genetic risk factor for Alzheimer disease, APOE ε4, which has an age of onset several decades earlier, a more aggressive clinical course and more severe neuropathological findings, especially in terms of the amount of amyloid deposition. +1 more finding

• Brain Biology
• Genetics
• Treatments

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Ready for Discharge, but Are They Ready to Go Home? Examining Neighborhood-Level Disadvantage as a Marker of the Social Exposome and the Swallowing Care Process in a Retrospective Cohort of Inpatients With Dementia

47/100 ✓ Peer-reviewed Risk factors American Journal of Speech-Language Pathology

Key finding: ADI was significantly higher in this cohort ( M = 3.84, SD = 2.58) than in the surrounding county ( M = 2.79, SD = 1.88, p = .000). +4 more findings

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Glymphatic system dysfunction predicts amyloid deposition, neurodegeneration, and clinical progression in Alzheimer's disease

71/100 ✓ Peer-reviewed Laboratory science Alzheimer's & Dementia

Key finding: Glymphatic failure may precede amyloid pathology, and predicts amyloid deposition, neurodegeneration, and clinical progression in AD. +1 more finding

• Brain Biology
• Brain Scans
• Early Stage

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Diagnosis of Alzheimer's disease: Towards accuracy and accessibility

43/100 ✓ Peer-reviewed Biomarkers Journal of biological methods

Key finding: Current clinical diagnosis is based on clinical symptoms, and clinical research demonstrated that positron emission tomography (PET) and cerebrospinal fluid (CSF) biomarkers had excellent diagnostic performance.

• Biomarkers
• Diagnosis
• Brain Biology

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Lecanemab: A Second in Class Therapy for the Management of Early Alzheimer's Disease

45/100 ✓ Peer-reviewed Treatments Innovations in pharmacy

Key finding: In addition to the significant cost challenges, the frequent infusions may pose concerns related to access.

• Treatments
• Clinical Trials
• Side Effects

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Phenotypes and ontogeny of senescent hepatic stellate cells in metabolic dysfunction-associated steatohepatitis

50/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of hepatology

Key finding: & aims Hepatic stellate cells (HSCs) are the key drivers of fibrosis in metabolic dysfunction-associated steatohepatitis (MASH), the fastest growing cause of hepatocellular carcinoma (HCC) worldwide. +3 more findings

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Risk of dementia due to Co-exposure to air pollution and neighborhood disadvantage

63/100 ✓ Peer-reviewed Risk factors Environmental research

Key finding: SDI score (aHR = 1.08; 95% CI 0.96, 1.22), joint air pollution (aHR = 1.03, 95% CI 0.92, 1.16) and joint SDI with air pollution (aHR = 1.04, 95% CI 0.89, 1.22) were not associated with dementia risk. +4 more findings

• Risk Factors

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Safety and efficacy of acupuncture for mild cognitive impairment: a study protocol for clinical study

57/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in neurology

Key finding: The findings of this protocol will provide information regarding the effects of acupuncture on MCI. +1 more finding

• Early Stage

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Comparison of cerebrospinal fluid, plasma and neuroimaging biomarker utility in Alzheimer's disease

50/100 ✓ Peer-reviewed Biomarkers Brain communications

Key finding: The results demonstrate that, although the number of biomarkers has rapidly expanded, many are interrelated and few strongly predict clinical outcomes.

• Biomarkers

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Racial and Ethnic Disparities in Neurological Care in the United States

43/100 ✓ Peer-reviewed Disparities Seminars in neurology

Key finding: Health services researchers have attempted to identify racial and ethnic disparities in neurological care and possible solutions. +4 more findings

• Health Equity

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Preliminary evidence for preserved synaptic density in late-life depression

50/100 ✓ Peer-reviewed Risk factors Translational psychiatry

Key finding: Late-life depression has been consistently associated with lower gray matter volume, the origin of which remains largely unexplained. +3 more findings

• Brain Scans
• Brain Biology

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Global, regional, and national burden of disorders affecting the nervous system, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021

48/100 ✓ Peer-reviewed How common it is The Lancet. Neurology

Key finding: As the leading cause of overall disease burden in the world, with increasing global DALY counts, effective prevention, treatment, and rehabilitation strategies for disorders affecting the nervous system are needed.

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Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants

45/100 ✓ Peer-reviewed Prevention and risk Archives of toxicology

Key finding: Given that there is a discrepancy between preclinical and clinical studies, approaches that may result in greater pharmacological and clinical success of low-molecular-weight antioxidant therapies are also subject to discussion.

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Lecanemab Questions

57/100 ✓ Peer-reviewed Treatments Neurology

Key finding: The recently published results of the 18-month randomized controlled trial of lecanemab, reporting the efficacy of the drug in slowing the progression of early Alzheimer disease, quickly led to approval by the FDA and widespread acceptance of lecanemab treatment. +3 more findings

• Treatments
• Clinical Trials

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Cost-Effectiveness of Lecanemab for Individuals With Early-Stage Alzheimer Disease

61/100 ✓ Peer-reviewed Costs and economics Neurology

Key finding: Neither targeted lecanemab treatment nor treatment unrestricted by APOE ε4 genotype is cost-effective vs SoC alone for patients with MCI or mild dementia due to AD. +1 more finding

• Policy
• Treatments
• Early Stage

Full summary, score breakdown and related studies → Original source