Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 19,251–19,275 of 27,380 studies, newest first · page 771 of 1096.
September 2012 7
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2012-09-01
Treatment strategies targeting amyloid β-protein
39/100 ✓ Peer-reviewed Risk genes beyond APOE Cold Spring Harbor perspectives in medicine
Key finding: This effort fully matured when it was clarified that the Aβ is a normal product of cleavage of the amyloid precursor protein, and well-defined proteases for this process were identified. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-09-01
Plasma microRNA biomarkers for detection of mild cognitive impairment
51/100 ✓ Peer-reviewed Mild cognitive impairment Aging
Key finding: Early stages of many neurodegenerative diseases, such as Alzheimer's disease, vascular and frontotemporal dementia, and Parkinson's disease, are frequently associated with Mild Cognitive Impairment (MCI). +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-09-01
Derivation and validation of automated electronic search strategies to extract Charlson comorbidities from electronic medical records
61/100 ✓ Peer-reviewed Digital health tools Mayo Clinic proceedings
Key finding: Our results suggest that search strategies that use automated electronic search strategies to extract Charlson comorbidities from the clinical notes contained within the electronic medical record are feasible and reliable. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-09-01
Diabetes, glucose control, and 9-year cognitive decline among older adults without dementia
66/100 ✓ Peer-reviewed Disparities Archives of neurology
Key finding: Among well-functioning older adults, DM and poor glucose control among those with DM are associated with worse cognitive function and greater decline. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-09-01
Neuropathological correlates of dopaminergic imaging in Alzheimer's disease and Lewy body dementias
48/100 ✓ Peer-reviewed Caregiving Brain : a journal of neurology
Key finding: Stepwise linear regression was performed to identify significant pathological predictors of striatal binding. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-09-01
Meta-analysis of nonpharmacological interventions for neuropsychiatric symptoms of dementia
65/100 ✓ Peer-reviewed Caregiving The American journal of psychiatry
Key finding: The successful interventions identified included approximately nine to 12 sessions tailored to the needs of the person with dementia and the caregiver and were delivered individually in the home using multiple components over 3-6 months with periodic follow-up.
Full summary, score breakdown and related studies → Original source
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2012-09-01
Increased cerebral metabolism after 1 year of deep brain stimulation in Alzheimer disease
50/100 ✓ Peer-reviewed Brain scans and imaging Archives of neurology
Key finding: Increased connectivity after 1 year of DBS is observed, which is in contrast to the decreased connectivity observed over the course of AD. +1 more finding
Full summary, score breakdown and related studies → Original source
August 2012 18
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2012-08-30
Interrelationship of oral health status, swallowing function, nutritional status, and cognitive ability with activities of daily living in Japanese elderly people receiving home care services due to physical disabilities
48/100 ✓ Peer-reviewed Clinical safety Community dentistry and oral epidemiology
Key finding: A lower number of teeth are positively related to swallowing dysfunction, whereas denture wearing contributes to recovery of swallowing function. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-08-30
Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women
47/100 ✓ Peer-reviewed TREM2 and immune genetics American journal of human genetics
Key finding: CRP levels are higher in African Americans and Hispanic Americans than in European Americans, but the genetic determinants of CRP in these admixed United States minority populations are largely unknown. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-08-30
Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, double-blind, placebo-controlled trial
63/100 ✓ Peer-reviewed Mild cognitive impairment Psychopharmacology
Key finding: Studies with larger sample sizes, longer intervention periods, different fish oil dosages and genetic determinations should be investigated before definite recommendations can be made.
Full summary, score breakdown and related studies → Original source
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2012-08-29
Glucagon-Like Peptide-1 Decreases Intracerebral Glucose Content by Activating Hexokinase and Changing Glucose Clearance during Hyperglycemia
47/100 ✓ Peer-reviewed Drug development Journal of Cerebral Blood Flow & Metabolism
Key finding: Reports indicate that glucagon-like peptide-1 (GLP-1) may be neuroprotective in models of AD and stroke: Although the mechanism is unclear, glucose homeostasis appears to be important.
Full summary, score breakdown and related studies → Original source
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2012-08-29
Investigating structural brain changes of dehydration using voxel-based morphometry
55/100 ✓ Peer-reviewed Mild cognitive impairment PloS one
Key finding: A significant decrease of GM and WM volume associated with dehydration was found in various brain regions, most prominently, in temporal and sub-gyral parietal areas, in the left inferior orbito-frontal region, and in the extra-nuclear region. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-08-29
Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43
48/100 ✓ Peer-reviewed Lewy body dementia Proceedings of the National Academy of Sciences of the United States of America
Key finding: We show that rapamycin treatment effectively rescues the learning/memory impairment of these mice at 3 mo of age, and it significantly slows down the age-dependent loss of their motor function. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-08-28
Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: a new avenue for a disease modifying treatment of Alzheimer's?
36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's ACS chemical neuroscience
Key finding: The DYRK1A gene is located within the Down syndrome critical region (DSCR) on human chromosome 21 and current research suggests that overexpression of DYRK1A may be a significant factor leading to cognitive deficits in people with Alzheimer's disease (AD) and Down syndrome (DS). +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-08-28
Neuropsychiatric symptoms and global functional impairment along the Alzheimer's continuum
47/100 ✓ Peer-reviewed Mild cognitive impairment Dementia and geriatric cognitive disorders
Key finding: These results suggest that increased baseline hallucinations, apathy and anxiety are associated with current and future disease progression in AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-08-27
Tau phosphorylation pathway genes and cerebrospinal fluid tau levels in Alzheimer's disease
38/100 ✓ Peer-reviewed Tau biomarkers American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
Key finding: Hyper-phosphorylated-tau (p-tau) contributes to neuronal damage, and both p-tau and total-tau (t-tau) levels are elevated in AD cerebrospinal fluid (CSF) compared to cognitively normal controls. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-08-24
Exosomal cell-to-cell transmission of alpha synuclein oligomers
40/100 ✓ Peer-reviewed Brain tissue and pathology Molecular neurodegeneration
Key finding: Our data suggest that αsyn may be secreted via different secretory pathways. +2 more findings
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2012-08-24
Mitochondria-associated ER membranes in Alzheimer disease
43/100 ✓ Peer-reviewed Brain scans and imaging Molecular and cellular neurosciences
Key finding: Alzheimer disease (AD) is associated with the accumulation in the brain of extracellular neuritic plaques composed mainly of β-amyloid (Aβ) and of intracellular neurofibrillary tangles composed of hyperphosphorylated forms of the microtubule-associated protein tau. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-08-23
Subjective cognitive complaints and amyloid burden in cognitively normal older individuals
36/100 ✓ Peer-reviewed Brain scans and imaging Neuropsychologia
Key finding: Accumulating evidence suggests that subjective cognitive complaints (SCC) may indicate subtle cognitive decline characteristic of individuals with preclinical Alzheimer's disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-08-22
Recommendations for optimal ICD codes to study neurologic conditions: a systematic review
60/100 ✓ Peer-reviewed Digital health tools Neurology
Key finding: Thirty full-text articles met the eligibility criteria.
Full summary, score breakdown and related studies → Original source
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2012-08-22
Donepezil in Parkinson's disease dementia: a randomized, double-blind efficacy and safety study
70/100 ✓ Peer-reviewed Treatments Movement disorders : official journal of the Movement Disorder Society
Key finding: This report presents an efficacy and safety study of the acetylcholinesterase inhibitor donepezil hydrochloride in PDD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-08-22
Correlations of CSF tau and amyloid levels with Alzheimer pathology in neuropathologically verified dementia with Lewy bodies
36/100 ✓ Peer-reviewed Tau biomarkers International journal of geriatric psychiatry
Key finding: The presence of concomitant Alzheimer pathology has been linked to earlier death in cases with dementia with Lewy bodies (DLB). +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-08-22
Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment
60/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: The cross-sectional difference in 2 independent neuroimaging modalities indicates early AD pathology in SMI. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-08-21
Hyperphosphorylation of Tau induced by naturally secreted amyloid-β at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3β signaling pathway
41/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: Although there is growing evidence for the pathogenic role of soluble Aβ species in AD, the major question of how Aβ induces hyperphosphorylation of Tau remains unanswered. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-08-20
Advance care planning and dying in nursing homes in Flanders, Belgium: a nationwide survey
47/100 ✓ Peer-reviewed End-of-life care Journal of pain and symptom management
Key finding: Prevalence of ACPs and formal authorization of a legal representative was low among the deceased NH residents in Flanders, Belgium. +1 more finding
Full summary, score breakdown and related studies → Original source
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