Newest studies

Social determinants of health and mild cognitive impairment in a diverse community sample

44/100 ✓ Peer-reviewed Risk factors Journal of the American Geriatrics Society

Key finding: In this cohort, several community‐wide social/environmental factors were associated with MCI. +2 more findings

• Health Equity
• Early Stage
• Risk Factors

Full summary, score breakdown and related studies → Original source

Metabolic Syndrome and the Risk of Alzheimer's Disease: A Meta-Analysis

89/100 ✓ Peer-reviewed Risk factors Metabolic syndrome and related disorders

Key finding: Six prospective cohort studies with seven datasets, including 484,994 participants and a follow-up of 3.5 to 13.0 years, were included. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

GLP-1 receptor signaling restores aquaporin 4 subcellular polarization in reactive astrocytes and promotes amyloid β clearance in a mouse model of Alzheimer's disease

43/100 ✓ Peer-reviewed Drug development Biochemical and biophysical research communications

Key finding: Next, we observed that 20-week subcutaneous administration of a GLP-1R agonist (GLP-1RA) liraglutide significantly reduced Aβ (1-42) accumulation in the cerebral cortex and improved spatial working memory in an AD mouse model, AppNL-G-F/NL-G-F mice. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Alzheimer's Disease Diagnosis and Management in the Age of Amyloid Monoclonal Antibodies

43/100 ✓ Peer-reviewed Treatments The Medical clinics of North America

Key finding: Alzheimer's disease (AD) is the most common neurodegenerative disorder, and for providers the term AD is often avoided, favoring generic terms like memory loss or dementia. +4 more findings

• Treatments
• Diagnosis

Full summary, score breakdown and related studies → Original source

Indirect Costs of Alzheimer's Disease: Unpaid Caregiver Burden and Patient Productivity Loss

50/100 ✓ Peer-reviewed Costs and economics Value in Health

Key finding: Conventional cost estimates, which do not consider unpaid caregiver burden and patient productivity loss, significantly underestimate the total burden of AD. +2 more findings

• Policy
• Caregiving

Full summary, score breakdown and related studies → Original source

The African American Dementia and Aging Project: an Oregon-based longitudinal study

68/100 ✓ Peer-reviewed Disparities Frontiers in dementia

Key finding: AADAPt participants had risk factors for developing dementia in future, such as hypertension and hyperlipidemia, but also reported protective factors such as high social engagement. +1 more finding

• Health Equity

Full summary, score breakdown and related studies → Original source

Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer's disease

63/100 ✓ Peer-reviewed Biomarkers Nature communications

Key finding: Both plasma and CSF NfL changes were associated with grey-matter atrophy, but not with Aβ-PET changes, supporting a temporal decoupling of Aβ deposition and neurodegeneration. +1 more finding

• Biomarkers
• Genetics

Full summary, score breakdown and related studies → Original source

The Mechanistic Link Between Tau-Driven Proteotoxic Stress and Cellular Senescence in Alzheimer's Disease

43/100 ✓ Peer-reviewed Disease mechanisms International journal of molecular sciences

Key finding: However, the impairment of tau degradation in neurons allows tau to be secreted into the extracellular space. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Effect of choline alfoscerate in older adult patients with dementia: an observational study from the claims data of national health insurance

44/100 ✓ Peer-reviewed Health systems and care delivery BMC geriatrics

Key finding: Partly due to its insurance coverage, this agent appears to incur significant expense for the insurance system. +2 more findings

• Policy
• Treatments

Full summary, score breakdown and related studies → Original source

Associations of plasma SMOC1 and soluble IL6RA levels with the progression from mild cognitive impairment to dementia

44/100 ✓ Peer-reviewed Tau biomarkers Brain, behavior, & immunity - health

Key finding: Moreover, there is debate on whether inflammation has a protective or detrimental effect on disease onset and progression. +3 more findings

• Biomarkers

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Residency in Long-Term Care Facilities: An Important Risk Factor for Respiratory Syncytial Virus Hospitalization

43/100 ✓ Peer-reviewed Health systems and care delivery The Journal of infectious diseases

Key finding: Older age and comorbid conditions increase risk for severe for respiratory syncytial virus (RSV). +4 more findings

• Care Services
• Risk Factors

Full summary, score breakdown and related studies → Original source

Assessment of sensory impairment in older adults with dementia

50/100 ✓ Peer-reviewed Risk factors Journal of otology

Key finding: Patients with dementia had significantly worse hearing at almost all frequencies tested and significantly greater olfactory impairment than cognitively normal controls. +4 more findings

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Evaluating Social Determinants of Health–Based Alternatives to Race-Based Cognitive Normative Models

57/100 ✓ Peer-reviewed Risk factors Neurology

Key finding: (n = 2,392) had a mean age of 74.4 years, 60.4% were female, and 17.1% were of self-reported Black race. +4 more findings

• Health Equity

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Comparison of the efficacy of updated drugs for the treatment on the improvement of cognitive function in patients with Alzheimer 's disease: A systematic review and network meta- analysis

52/100 ✓ Peer-reviewed Treatments Neuroscience

Key finding: Donanemab and Lecanemab showed good efficacy in ADCS-ADL and CDR-SB, respectively. +4 more findings

• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Passive anti-amyloid β immunotherapy in Alzheimer's disease-opportunities and challenges

48/100 ✓ Peer-reviewed Treatments Lancet (London, England)

Key finding: We discuss clinical trial results of aducanumab, lecanemab, and donanemab.

• Treatments

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Spatial Transcriptomic Analysis Identifies a SERPINA3-Expressing Astrocytic State Associated with the Human Neuritic Plaque Microenvironment

16/100 ⚠ Preprint — not yet peer-reviewed Genetics bioRxiv : the preprint server for biology

Key finding: Single-nucleus transcriptomic studies have revealed glial cell states associated with Alzheimer's disease; however, these nuclei are dissociated from the complex architecture of the human neocortex. +1 more finding

• Brain Biology

Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

A Proteomics-Based Approach for Prediction of Different Cardiovascular Diseases and Dementia

62/100 ✓ Peer-reviewed Long-term cohort studies Circulation

Key finding: Many studies have explored whether individual plasma protein biomarkers improve cardiovascular disease risk prediction. +3 more findings

• Risk Factors

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Leqembi Recommended for Treatment of Early Alzheimer's Disease (CHMP re-examination, reversing July 2024 refusal)

15/100 ⚠ Regulatory decision — not a study Treatments European Medicines Agency

Key finding: July 2024: CHMP issued a negative opinion for broad use, citing ARIA risk outweighing modest cognitive benefit +2 more findings

• Treatments

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Large-scale deep proteomic analysis in Alzheimer's disease brain regions across race and ethnicity

46/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: While amyloid precursor protein and the microtubule-associated protein tau demonstrated higher abundance in AD brains, no significant race-related differences were observed. +4 more findings

• Health Equity
• Brain Biology

Full summary, score breakdown and related studies → Original source

Cognitive reserve against Alzheimer's pathology is linked to brain activity during memory formation

71/100 ✓ Peer-reviewed Risk factors Nature communications

Key finding: The cognitive reserve (CR) hypothesis posits that individuals can differ in how their brain function is disrupted by pathology associated with aging and neurodegeneration. +2 more findings

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Cerebral perfusion and amyloidosis in the oldest-old

70/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Participants with CIND displayed lower perfusion in the PCC+PCu relative to participants who were CN, but there was no statistically significant difference between the groups in amyloid burden in this region. +4 more findings

• Brain Scans

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The ADNI Administrative Core: Ensuring ADNI's success and informing future AD clinical trials

55/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: The overall goal is to ensure ADNI's success and help design future Alzheimer's disease (AD) clinical trials.

• Clinical Trials

Full summary, score breakdown and related studies → Original source

Plasma Alzheimer's disease biomarker variability: Amyloid-independent and amyloid-dependent factors

61/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Aβ-independent factors included hemoglobin and estimated glomerular filtration rate (eGFR) for p-tau217 and hemoglobin, eGFR, and triiodothyronine (T3) for GFAP and NfL. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Amyloid Imaging Update: How the Amyloid Landscape Is Changing in Light of the Recent Food and Drug Administration Approval of Antiamyloid Therapeutics

30/100 ✓ Peer-reviewed Health systems and care delivery Journal of nuclear medicine technology

Key finding: Although the latter is more cost-effective and has no associated radiation exposure, it is highly invasive compared with amyloid PET.

• Treatments
• Brain Scans

Full summary, score breakdown and related studies → Original source

Understanding perspectives and research trends in Down syndrome neuropathogenesis: A bibliometric analysis

30/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of intellectual disabilities : JOID

Key finding: Analysing 5,082 papers, the U.S. demonstrated prominence with the highest number of research organisations and citations. +1 more finding

• Down Syndrome

Full summary, score breakdown and related studies → Original source