Newest studies

Transferrin receptor-targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA

47/100 ✓ Peer-reviewed Treatments Science (New York, N.Y.)

Key finding: Taken together, ATV cisLALA has the potential to improve the next generation of Aβ immunotherapy through enhanced biodistribution mediated by transport across the blood-brain barrier.

• Treatments
• Side Effects
• Brain Biology

Full summary, score breakdown and related studies → Original source

Nanocarrier-based drug delivery for mild cognitive impairment: Extracellular vesicles and carbon nanotubes as emerging therapeutic tools

32/100 ✓ Peer-reviewed Mild cognitive impairment Biomedicine & Pharmacotherapy

Key finding: As MCI becomes increasingly prevalent in aging populations, there is an urgent need for innovative, targeted strategies to slow its progression. +4 more findings

• Early Stage
• Treatments

Full summary, score breakdown and related studies → Original source

Longitudinal structural MRI-based deep learning and radiomics features for predicting Alzheimer’s disease progression

55/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s Research & Therapy

Key finding: A single-timepoint ResNet3D model achieved modest performance (c-index ~ 0.70). +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Social isolation and loneliness as modifiable risk factors for dementia: Evidence-based interventions and public health implications

52/100 ✓ Peer-reviewed Risk factors Advanced Neurology

Key finding: Social isolation and loneliness have emerged as significant and modifiable risk factors for dementia, especially in older adults. +1 more finding

• Risk Factors
• Lifestyle
• Prevention

Full summary, score breakdown and related studies → Original source

Racial disparities in the association of epigenetic age acceleration with the transition between normal cognition, mild cognitive impairment and dementia

40/100 ✓ Peer-reviewed Disparities Global Transitions

Key finding: Exposure to accelerated epigenetic aging was significantly associated with a higher risk of transition from NC to MCI as well as progression from MCI to dementia. +4 more findings

• Health Equity
• Early Stage

Full summary, score breakdown and related studies → Original source

The potential for dementia prevention in Brazil: a population attributable fraction calculation for 14 modifiable risk factors

58/100 ✓ Peer-reviewed Prevention and risk The Lancet Regional Health - Americas

Key finding: The overall PAF for the 14 modifiable risk factors was 59.5% (95% CI = 58.5-60.5). +4 more findings

• Prevention
• Risk Factors

Full summary, score breakdown and related studies → Original source

Reprogramming Atherosclerosis: Precision Drug Delivery, Nanomedicine, and Immune-Targeted Therapies for Cardiovascular Risk Reduction

44/100 ✓ Peer-reviewed Prevention and risk Pharmaceutics

Key finding: Ligand-based, biomimetic, and stimuli-responsive delivery systems further enhance spatial and temporal precision. +4 more findings

• Treatments
• Prevention
• Brain Biology

Full summary, score breakdown and related studies → Original source

MIND Diet and Hippocampal Sclerosis Among Community-Based Older Adults

60/100 ✓ Peer-reviewed Genetics JAMA Network Open

Key finding: Among 809 participants (mean [SD] age at death, 91.3 [6.1] years; 538 [72%] female; mean [SD] follow-up, 7.2 [4.4] years), HS was present in 82 (10.1%) participants; 71 participants (9%) had both HS and LATE-NC, and in the scored subset, 43 participants (14%) had moderate and 35 participants (12%) had severe hippocampal neuronal loss. +4 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

A comprehensive review on novel opportunities for Alzheimer therapy by targeting BIN1

36/100 ✓ Peer-reviewed Genetics Egyptian Journal of Medical Human Genetics

Key finding: Research revealed a significant locus of susceptibility for LOAD on the Bridging Integrator 1 (BIN1) that is situated on chromosome 2q14.3 and is identified at the time of the most significant susceptibility gene of LOAD. +1 more finding

Full summary, score breakdown and related studies → Original source

Contributions of pharmaceutical interventions to the multidisciplinary dysphagia team: A retrospective observational study

32/100 ✓ Peer-reviewed Health systems and care delivery Journal of pharmaceutical health care and sciences

Key finding: This study aimed to validate these findings through a clinical examination of pharmaceutical interventions performed by a multidisciplinary dysphagia team. +2 more findings

• Treatments

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Unravelling the genetic architecture of cerebral small vessel disease in the context of stroke

39/100 ✓ Peer-reviewed Vascular contributions Journal of Cerebral Blood Flow & Metabolism

Key finding: Despite significant progress through large-scale genome-wide association studies (GWAS) for cSVD and stroke, the genetic architecture underlying these conditions remains poorly understood.

• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

Retinal vascular reactivity is associated with white matter hyperintensities and dysfunctional cerebrovascular reactivity in cerebral small vessel disease

48/100 ✓ Peer-reviewed Vascular contributions Journal of Cerebral Blood Flow & Metabolism

Key finding: Participants had retinal photographs and magnetic resonance brain imaging (MRI) before and during inhalation of 6% CO 2 in air. +4 more findings

• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Development and Validation of the End‐of‐Life Assessment Tool for Advanced Dementia: A Multi Method Study

42/100 ✓ Peer-reviewed End-of-life care Journal of Advanced Nursing

Key finding: The item-bank included 180 symptoms, most of which focus group nurses (n = 17) identified as occurring in advanced dementia. +4 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Does Non-Beneficial Nasogastric Tube Feeding Occur During End-of-Life Care? An Audit of Outcomes for Those with a Malnutrition Universal Screening Tool Score of 2

39/100 ✓ Peer-reviewed End-of-life care Journal of Palliative Medicine

Key finding: Of these 84, 28 (33%) died during admission. +4 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Effect of aspirin use on conversion risk from mild cognitive impairment to Alzheimer’s disease

55/100 ✓ Peer-reviewed Mild cognitive impairment Frontiers in Aging Neuroscience

Key finding: The data of 508,107 individuals were analyzed (mean [standard deviation] age, 67.6 [10.7] years; 66.8% women and 33.2% men), and 39,318 developed Alzheimer's disease (22,572 controls and 16,746 using aspirin). +4 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Multi-omics profiling reveals two distinct trajectories in the progression from mild cognitive impairment to Alzheimer's disease

33/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Alzheimer s Disease

Key finding: BackgroundAlzheimer's disease (AD) exhibits significant clinical and pathological heterogeneity, particularly during the mild cognitive impairment (MCI) transitional stage.

• Early Stage

Full summary, score breakdown and related studies → Original source

Health Awareness and Dementia Risk Among Older Adults with Hypertension and Diabetes: A Cross-sectional Study in Thailand

32/100 ✓ Peer-reviewed Risk factors Iranian Journal of Psychiatry and Behavioral Sciences

Key finding: Participants exhibited strong awareness of the risks associated with complications and the severity of chronic diseases. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Impacts of Environmental Distractions and Interruptions on Unsupervised Digital Cognitive Assessments in Older Adults: Cognitive Ecological Momentary Assessment Study

44/100 ✓ Peer-reviewed Getting a diagnosis JMIR mhealth and uhealth

Key finding: Across all participants, momentary effects of environmental distractions were minimal. +4 more findings

• Diagnosis

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Utility of combination of Mini-Mental State Examination and Montreal Cognitive Assessment to predict incident Alzheimer's disease dementia in patients at high vascular risks

38/100 ✓ Peer-reviewed Getting a diagnosis Journal of Alzheimer s Disease

Key finding: Patients diagnosed with MCI with MMSE scores <28 or MoCA scores <26 showed a significantly higher risk of AD dementia than those with normal MMSE or MoCA groups. +1 more finding

• Diagnosis
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Portable platform for measuring amyloid beta 42/40 ratio via photooxidation-induced fluorescence amplification

43/100 ✓ Peer-reviewed Biomarkers Lab on a chip

Key finding: By measuring 38 cases of subjective cognitive decline (SCD), 24 cases of amnestic mild cognitive impairment (aMCI), and 46 cases of AD dementia samples, we observed a significant difference in Aβ 42/40 ratios between the SCD and aMCI groups. +1 more finding

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

The role of Tau, amyloid-β and neuroinflammation in the association between cognition and white matter hyperintensities in a southeast Asian cohort

44/100 ✓ Peer-reviewed Vascular contributions The Journal of Prevention of Alzheimer s Disease

Key finding: WMH burden positively correlated to Neurofilament-Light (NfL) and pTau181. +4 more findings

• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

Engaging in the Life-planning in Early Alzheimer’s and other Dementias advance care planning intervention is associated with perceived advance care planning concordance and interpersonal connectedness

40/100 ✓ Peer-reviewed End-of-life care The Gerontologist

Key finding: N = 48 community-based dyads completed the LEAD intervention, with N = 43 answering open-ended questions. +4 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

ApoE-calypse tau: ApoE–tau synergy in Alzheimer’s disease

45/100 ✓ Peer-reviewed Disease mechanisms The Journal of Experimental Medicine

Key finding: While much of the research has focused on Aβ, tau-mediated neurodegeneration is more closely associated with synaptic loss and cognitive decline in AD, emphasizing the need for a deeper understanding of tau pathology. +1 more finding

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Adaptive immunity in the neuroinflammation of Alzheimer’s disease

38/100 ✓ Peer-reviewed Inflammation and the immune system Chinese Medical Journal

Key finding: Alzheimer's disease (AD) is the most common cause of dementia and is a growing public health challenge. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Association of sugar intake with incident dementia in the UK Biobank: a prospective cohort study

41/100 ✓ Peer-reviewed Long-term cohort studies The Journal of Prevention of Alzheimer s Disease

Key finding: Higher intakes of total sugar (HR = 1.292, 95 % CI = 1.148--1.453) and free sugar intake (HR = 1.254, 95 % CI = 1.117--1.408) were significantly associated with increased dementia risk. +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source