Newest studies

Federated learning with multi‐cohort real‐world data for predicting the progression from mild cognitive impairment to Alzheimer's disease

42/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s & Dementia

Key finding: Of 44,899 MCI patients, 6391 progressed to AD. +4 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Brain‐derived tau to measure treatment effect in Alzheimer's disease and frontotemporal dementia

41/100 ✓ Peer-reviewed Lewy body dementia Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring

Key finding: CSF BD‐tau shows potential as a biomarker of treatment effect in AD but not bvFTD.

• Other Dementias
• Treatments
• Biomarkers

Full summary, score breakdown and related studies → Original source

Impact of hypersexuality on spousal carers of patients with Parkinson’s disease and frontotemporal dementia: a qualitative study

40/100 ✓ Peer-reviewed Lewy body dementia BMJ Open

Key finding: The thematic analysis identified 12 themes: manifestations, sexual practices, impact, control, emotional formulations, beliefs in causes of hypersexuality and attributions, relationship with the partner, dealing with hypersexuality, coping with hypersexuality, self-image, stigma and professional help-seeking. +4 more findings

• Other Dementias
• Caregiving

Full summary, score breakdown and related studies → Original source

Ethics of disclosure of onset‐predictive biomarker test results for genetic frontotemporal dementia in the research context

39/100 ✓ Peer-reviewed Lewy body dementia Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring

Key finding: OPBT results could be used as inclusion criterion for clinical trials for FTD, but this requires disclosure of OPBT results to potential participants for informed consent. +3 more findings

• Other Dementias
• Biomarkers
• Genetics

Full summary, score breakdown and related studies → Original source

Genome‐wide association analysis identifies APOE as a mitophagy modifier in Lewy body disease

43/100 ✓ Peer-reviewed Lewy body dementia Alzheimer s & Dementia

Key finding: We identified a significant genome-wide association with p-S65-Ub for rs429358 (apolipoprotein E ε4 [APOE4]) and a suggestive association for rs6480922 (ZMIZ1). +4 more findings

• Genetics
• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Sex differences in the executive and behavioral reserve of autosomal dominant frontotemporal dementia

56/100 ✓ Peer-reviewed Lewy body dementia Alzheimer s & Dementia

Key finding: Symptomatic females with genetic FTD had lower frontal cortical thickness than males, and the C9orf72 subgroup showed lower-than-expected frontal cortical thickness for a given level of executive functioning. +4 more findings

• Other Dementias
• Genetics

Full summary, score breakdown and related studies → Original source

Human MAPT knockin mouse models of frontotemporal dementia for the neurodegenerative research community

39/100 ✓ Peer-reviewed Lewy body dementia Cell Reports Methods

Key finding: These findings establish the mutant mice as valuable models for investigating the mechanisms underlying FTD and other tauopathies, providing a relevant platform for in vivo drug screening.

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia

52/100 ✓ Peer-reviewed Lewy body dementia Alzheimer s & Dementia

Key finding: Females with sporadic bvFTD showed worse compulsive behavior (p = 0.026) and language impairments (p = 0.024) compared to females with genetic bvFTD (n = 152). +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Sex differences in the clinical manifestation of autosomal dominant frontotemporal dementia

63/100 ✓ Peer-reviewed Lewy body dementia Alzheimer s & Dementia

Key finding: While sex differences were not apparent at asymptomatic stages, females showed more rapid declines across all outcomes in symptomatic stages compared to males. +4 more findings

• Genetics
• Other Dementias
• Biomarkers

Full summary, score breakdown and related studies → Original source

Diabetes and dementia: current data

28/100 ✓ Peer-reviewed Risk factors INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine)

Key finding: Long-term metformin use is associated with a 29–84 % reduced risk of dementia, depending on therapy duration, and its combination with other drugs may provide synergy in slowing neurodegeneration.

• Risk Factors
• Treatments
• Diagnosis

Full summary, score breakdown and related studies → Original source

Alzheimer's and dementia: Diagnosis, assessment, and disease monitoring global, regional, and national burden of Alzheimer's disease and other dementias (ADODs) and their risk factors, 1990–2021: A systematic analysis for the Global Burden of Disease study 2021

38/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring

Key finding: Between 1990 and 2021, ADOD incidence, prevalence, deaths, and DALYs increased significantly. +4 more findings

• Risk Factors
• Diagnosis

Full summary, score breakdown and related studies → Original source

White matter hyperintensity spatial patterns: Risk factors and clinical correlates

61/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: WMHs in the frontoparietal and anterior periventricular region were associated with blood pressure traits, WMH genetic risk score (GRS), baseline and decline in general cognitive performance, incident all-cause dementia, and ischemic stroke. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

The Impact of Behavioral and Psychological Symptoms of Dementia on Mental Health, Sleep Quality, and Caregiver’s Burden

43/100 ✓ Peer-reviewed Risk factors International Journal of Geriatric Psychiatry

Key finding: Caregivers of patients with BPSD reported significantly greater psychological distress, burden, and poorer sleep quality than those caring for patients without BPSD. +4 more findings

• Caregiving
• Lifestyle

Full summary, score breakdown and related studies → Original source

Social Frailty and Social Isolation in the Context of Dementia: A Simultaneous Concept Analysis

37/100 ✓ Peer-reviewed Risk factors International Journal of Geriatric Psychiatry

Key finding: The attributes of concepts of social frailty and social isolation overlap, including being alone and having limited or less social activities, engagements or interactions. +4 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

Risk Factors, Pathological Changes, and Potential Treatment of Diabetes‐Associated Cognitive Dysfunction

42/100 ✓ Peer-reviewed Risk factors Journal of Diabetes

Key finding: Several risk factors contribute to DACD, including hyperglycemia, hypoglycemia, blood sugar fluctuations, hyperinsulinemia, aging, and others. +3 more findings

• Risk Factors
• Treatments

Full summary, score breakdown and related studies → Original source

Machine learning–enhanced screening funnel for clinical trials in Alzheimer's disease

33/100 ✓ Peer-reviewed Digital health tools Alzheimer s & Dementia Translational Research & Clinical Interventions

Key finding: This approach predicts clinical progression (2-year Clinical Dementia Rating Sum of Boxes change > 1) with an area under the curve of 0.836. +3 more findings

• Digital Tools
• Clinical Trials
• Diagnosis

Full summary, score breakdown and related studies → Original source

Effects of Medicare predictors in health disparities in the risk of Alzheimer's disease

35/100 ✓ Peer-reviewed Disparities Alzheimer s & Dementia Translational Research & Clinical Interventions

Key finding: Low income and vulnerability to arterial hypertension were the primary contributors to AD/ADRD disparities, with cerebrovascular diseases and depression as notable secondary predictors. +4 more findings

• Health Equity
• Risk Factors

Full summary, score breakdown and related studies → Original source

Improving quality measurement for dementia care

40/100 ✓ Peer-reviewed Disparities Alzheimer s & Dementia

Key finding: Highlights US dementia care needs better measurement tools to assess quality and inequities. +4 more findings

• Health Equity
• Policy

Full summary, score breakdown and related studies → Original source

Building a Regional Community-Based Participatory Research Model for Alzheimer’s Disease and Related Dementias for Rural Communities

33/100 ✓ Peer-reviewed Disparities International Journal of Qualitative Methods

Key finding: To address this issue, Memory Keepers Medical Discovery Team (MK-MDT) has developed a regional CBPR model for dementia research that incorporates multiple rural communities across northern Minnesota, which builds unique regional knowledge allowing for regional comparisons. +4 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source

Can annual wellness visits reduce disparity in early dementia diagnosis?

44/100 ✓ Peer-reviewed Disparities Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring

Key finding: Medicare beneficiaries who received an AWV were 13% to 21% more likely than those without an AWV to be diagnosed at MCI stage versus ADRD stage. +4 more findings

• Health Equity
• Diagnosis

Full summary, score breakdown and related studies → Original source

Leveraging data, technology, and policy to address disparities for persons living with Alzheimer's disease and Alzheimer's disease related dementias

41/100 ✓ Peer-reviewed Disparities Alzheimer s & Dementia

Key finding: Recommendations present considerations for future research and opportunities to strengthen policies related to the care of persons living with AD/ADRD. +4 more findings

• Health Equity
• Policy
• Digital Tools

Full summary, score breakdown and related studies → Original source

Qualitative and quantitative educational disparities and brain signatures in healthy aging and dementia across global settings

59/100 ✓ Peer-reviewed Disparities EClinicalMedicine

Key finding: Less EQ and YoE were associated with brain alterations across groups. +1 more finding

• Health Equity

Full summary, score breakdown and related studies → Original source

An especially hidden population: sexual and gender minority dementia caregivers

44/100 ✓ Peer-reviewed Caregiving Alzheimer s & Dementia

Key finding: Bisexual caregivers reported more stress, albeit better health than gay caregivers. +4 more findings

• Caregiving
• Health Equity

Full summary, score breakdown and related studies → Original source

2025 Alzheimer's disease facts and figures

56/100 ✓ Peer-reviewed Caregiving Alzheimer s & Dementia

Key finding: However, 2023 data indicate that Alzheimer's will likely resume its place as the sixth‐leading cause of death. +3 more findings

Full summary, score breakdown and related studies → Original source

A Robust Deep Vision Transformer Model For Early Diagnosis Of Alzheimers Disease

27/100 ✓ Peer-reviewed Brain scans and imaging International Journal of Research Publication and Reviews

Key finding: A progressive neurological disease, Alzheimer's disease (AD) is identified by cognitive decline and memory loss.

• Diagnosis
• Early Stage

Full summary, score breakdown and related studies → Original source