Newest studies

Long-term potentiation in the hippocampus: From magnesium to memory

43/100 ✓ Peer-reviewed Disease mechanisms Neuroscience

Key finding: Here I describe how my own work on NMDARs has been so profoundly influenced by this seminal discovery. +4 more findings

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Altered expression of Presenilin2 impacts endolysosomal homeostasis and synapse function in Alzheimer's disease-relevant brain circuits

46/100 ✓ Peer-reviewed Disease mechanisms Nature communications

Key finding: Both models showed significant deficits in working memory that linked to elevated PSEN2 expression in the hippocampal CA3 region. +1 more finding

• Brain Biology
• Genetics

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The role of neuroinflammation in cerebral amyloid angiopathy

45/100 ✓ Peer-reviewed Treatments EBioMedicine

Key finding: CAA is often seen in the brains of elderly individuals and in a majority of patients with Alzheimer's disease. +4 more findings

• Brain Biology

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Relationship between physical activity and biomarkers of pathology and neuroinflammation in preclinical autosomal-dominant Alzheimer's disease

63/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (New York, N. Y.)

Key finding: There were no associations among steps or TRIMP with plasma biomarkers or cognition. +4 more findings

• Biomarkers
• Early Stage
• Lifestyle

Full summary, score breakdown and related studies → Original source

Targeting Endogenous Tau in Seeded Tauopathy Models Inhibits Tau Spread

43/100 ✓ Peer-reviewed Drug development The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: Over the last decade, studies have demonstrated that targeting total or pathological tau using tau antibodies can mitigate the development of tau pathology in tauopathy or Alzheimer's disease (AD) mouse models, and multiple tau immunotherapy agents have progressed to clinical trials. +3 more findings

• Brain Biology

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Use of Artificial Intelligence in Imaging Dementia

45/100 ✓ Peer-reviewed Treatments Cells

Key finding: In patients with amyloid-related imaging abnormalities, radiologists had significantly better detection performances with both ARIA-E (sensitivity higher in the assisted/deep learning method [87%] compared to unassisted [71%]) and for ARIA-H signs (sensitivity was higher in assisted [79%] compared to unassisted [69%]).

• Brain Scans
• Digital Tools
• Early Stage

Full summary, score breakdown and related studies → Original source

Communication Bridge-2 randomized controlled trial: Recruitment and baseline features

80/100 ✓ Peer-reviewed Clinical trials Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Ninety-five participant dyads (PPA mean baseline age: 67.1; 48% female) from four countries were enrolled and randomized. +4 more findings

• Clinical Trials

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Heritability of Alzheimer's disease plasma biomarkers: A nuclear twin family design

52/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Heritability estimates were 16% for Aβ42/40, 42% for NfL, and 60% for GFAP. +4 more findings

• Biomarkers
• Genetics

Full summary, score breakdown and related studies → Original source

Alzheimer's Disease polygenic risk, the plasma proteome, and dementia incidence among UK older adults

48/100 ✓ Peer-reviewed Biomarkers GeroScience

Key finding: The study found that AD PRS tertiles significantly increased the risk for all-cause dementia, particularly among women. +4 more findings

• Biomarkers
• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Blood-brain barrier permeable β-blockers association with Alzheimer's disease cerebrospinal fluid biomarkers levels in non-demented individuals

52/100 ✓ Peer-reviewed Tau biomarkers Journal of Alzheimer's disease : JAD

Key finding: We found that CSF amyloid-β levels were higher in individuals taking highly permeable β-blockers in the ADNI sample. +2 more findings

• Biomarkers
• Brain Biology

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The importance of cognitive correlates of plasma amyloid-β 42/40

43/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD

Key finding: This commentary focuses on the clinical utility of plasma amyloid-β (Aβ) 42/40 to detect semantic intrusion errors in amnestic mild cognitive impairment, as investigated Curiel Cid et al. in a recent issue of the Journal of Alzheimer's Disease. +1 more finding

• Biomarkers

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Metformin effectively alleviates the symptoms of Alzheimer in rats by lowering amyloid β deposition and enhancing the insulin signal

37/100 ✓ Peer-reviewed Biomarkers Metabolic brain disease

Key finding: The levels of Aβ deposition increased, while IRS-2 expression subsided, accompanied by alterations in the hippocampal structure and neuronal damage. +4 more findings

• Brain Biology

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Cassava Sciences Topline Phase 3 Data Did Not Meet Co-Primary Endpoints (ReThink-ALZ)

16/100 ⚠ Press release — not a study Clinical trials GlobeNewswire (company press release); trial registered as NCT04994483

Key finding: 804 participants randomized 1:1 to simufilam or placebo +4 more findings

• Clinical Trials

Scored 44 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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GABA and its receptors' mechanisms in the treatment of insomnia

43/100 ✓ Peer-reviewed Risk factors Heliyon

Key finding: It can ameliorate Insomnia, Alzheimer's disease, Parkinson's disease, Epilepsy, and other neurological disorders. +4 more findings

• Treatments

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A data-driven, multi-domain brain gray matter signature as a powerful biomarker associated with several clinical outcomes

50/100 ✓ Peer-reviewed Prevention trials Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: In a separate validation set, the Union Signature demonstrates clinically relevant properties. +4 more findings

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Association of a pace of aging epigenetic clock with rate of cognitive decline in the Framingham Heart Study Offspring Cohort

61/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Participants with faster DunedinPACE had poorer cognitive functioning at baseline and experienced more rapid cognitive decline over follow-up. +4 more findings

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Performance of plasma p-tau217 and NfL in an unselected memory clinic setting

50/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: p-Tau217 levels were highest in patients with Alzheimer's disease (AD) dementia, whereas NfL levels were highest in patients with frontotemporal dementia (FTD). +4 more findings

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Post hoc analysis of ADAMANT, a phase 2 clinical trial of active tau immunotherapy with AADvac1 in patients with Alzheimer's disease, positive for plasma p-tau217

65/100 ✓ Peer-reviewed Inflammation and the immune system Alzheimer's research & therapy

Key finding: These results suggest that AADvac1 tau immunotherapy can reduce plasma biomarkers of neurodegeneration and neuroinflammation. +3 more findings

• Clinical Trials
• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer's disease

46/100 ✓ Peer-reviewed Genetics Nature genetics

Key finding: Spatial co-expression network analyses revealed transient and regionally restricted disease processes, including a glial inflammatory program dysregulated in upper cortical layers and implicated in AD genetic risk and amyloid-associated processes.

• Genetics

Full summary, score breakdown and related studies → Original source

Genome-wide association neural networks identify genes linked to family history of Alzheimer's disease

50/100 ✓ Peer-reviewed Genetics Briefings in bioinformatics

Key finding: Our method identified 18 genes to be associated with family history of AD. +2 more findings

• Genetics
• Digital Tools

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Galantamine-Memantine Combination in the Treatment of Parkinson's Disease Dementia

50/100 ✓ Peer-reviewed Treatments Brain sciences

Key finding: While randomized controlled trials (RCTs) with each drug alone for PD have failed, the combination of galantamine and memantine has demonstrated a synergistic effect on cognitive enhancement in animal models.

• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Can the clinical sign "head-turning sign" and simple questions in "Neucop-Q" predict amyloid β pathology?

52/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: The specificity and positive predictive value (PPV) of HTS positivity (HTSpos) were the highest (amyloid PET: 0.930 and 0.870, tau PET: 0.944 and 0.957, respectively), while Cimp and Nimp had a high negative predictive value (NPV) for amyloid PET (negativity) (0.750 and 0.725). +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

A Mindfulness-Based Lifestyle Intervention for Dementia Risk Reduction: Protocol for the My Healthy Brain Feasibility Randomized Controlled Trial

64/100 ✓ Peer-reviewed Treatments JMIR research protocols

Key finding: Our pilot studies (National Institutes of Health [NIH] stage 1A) have shown that MHB is feasible, acceptable, and associated with improvement in lifestyle behavior and cognitive outcomes. +3 more findings

• Clinical Trials
• Risk Factors
• Lifestyle

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[Radiological Identification and Evaluation of Amyloid-Related Imaging Abnormalities in Alzheimer's Disease]

43/100 ✓ Peer-reviewed Treatments Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

Key finding: Amyloid-related imaging abnormalities (ARIA), intracranial signal abnormalities observed in magnetic resonance imaging (MRI), represent one of the main adverse events associated with treating Alzheimer's disease (AD) with anti-amyloid-β (anti-Aβ) monoclonal antibodies. +1 more finding

• Treatments
• Side Effects
• Brain Scans

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Neuropathology meets chemical and genetic pathology head-on: a personal perspective

43/100 ✓ Peer-reviewed Biomarkers Pathology

Key finding: Medical science has made revolutionary discoveries around the nosology and aetiology of the neurodegenerative diseases. +4 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source